ID U2N3W3_SERFO Unreviewed; 798 AA. AC U2N3W3; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 14-DEC-2022, entry version 37. DE RecName: Full=Acyl-coenzyme A dehydrogenase {ECO:0000256|ARBA:ARBA00020144}; DE EC=1.3.8.7 {ECO:0000256|ARBA:ARBA00012033}; DE EC=1.3.8.8 {ECO:0000256|ARBA:ARBA00012040}; GN ORFNames=L580_2666 {ECO:0000313|EMBL:ERK06119.1}; OS Serratia fonticola AU-P3(3). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Yersiniaceae; Serratia. OX NCBI_TaxID=1332070 {ECO:0000313|EMBL:ERK06119.1, ECO:0000313|Proteomes:UP000016623}; RN [1] {ECO:0000313|EMBL:ERK06119.1, ECO:0000313|Proteomes:UP000016623} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AU-P3(3) {ECO:0000313|Proteomes:UP000016623}; RX PubMed=24233592; RA Devi U., Khatri I., Kumar N., Kumar L., Sharma D., Subramanian S., RA Saini A.K.; RT "Draft Genome Sequence of a Plant Growth-Promoting Rhizobacterium, Serratia RT fonticola Strain AU-P3(3)."; RL Genome Announc. 1:e00946-e00913(2013). CC -!- CATALYTIC ACTIVITY: CC Reaction=a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized CC [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + CC reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:17721, CC Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:83721, CC ChEBI:CHEBI:83727; EC=1.3.8.8; CC Evidence={ECO:0000256|ARBA:ARBA00001344}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized CC [electron-transfer flavoprotein] = a medium-chain (2E)-enoyl-CoA + CC reduced [electron-transfer flavoprotein]; Xref=Rhea:RHEA:14477, CC Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:83723, CC ChEBI:CHEBI:83726; EC=1.3.8.7; CC Evidence={ECO:0000256|ARBA:ARBA00034035}; CC -!- COFACTOR: CC Name=FAD; Xref=ChEBI:CHEBI:57692; CC Evidence={ECO:0000256|ARBA:ARBA00001974}; CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation. CC {ECO:0000256|ARBA:ARBA00005005}. CC -!- SIMILARITY: Belongs to the acyl-CoA dehydrogenase family. CC {ECO:0000256|ARBA:ARBA00009347}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:ERK06119.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; ASZB01000024; ERK06119.1; -; Genomic_DNA. DR AlphaFoldDB; U2N3W3; -. DR PATRIC; fig|1332070.3.peg.4223; -. DR UniPathway; UPA00659; -. DR Proteomes; UP000016623; Unassembled WGS sequence. DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro. DR GO; GO:0004466; F:long-chain-acyl-CoA dehydrogenase activity; IEA:UniProtKB-EC. DR GO; GO:0070991; F:medium-chain-acyl-CoA dehydrogenase activity; IEA:UniProtKB-EC. DR GO; GO:0033539; P:fatty acid beta-oxidation using acyl-CoA dehydrogenase; IEA:InterPro. DR Gene3D; 1.10.540.10; -; 1. DR Gene3D; 2.40.110.10; -; 1. DR InterPro; IPR006091; Acyl-CoA_Oxase/DH_mid-dom. DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf. DR InterPro; IPR036250; AcylCo_DH-like_C. DR InterPro; IPR009075; AcylCo_DH/oxidase_C. DR InterPro; IPR013786; AcylCoA_DH/ox_N. DR InterPro; IPR037069; AcylCoA_DH/ox_N_sf. DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom. DR InterPro; IPR015396; FadE_C. DR Pfam; PF09317; ACDH_C; 1. DR Pfam; PF00441; Acyl-CoA_dh_1; 1. DR Pfam; PF02770; Acyl-CoA_dh_M; 1. DR Pfam; PF02771; Acyl-CoA_dh_N; 1. DR SUPFAM; SSF47203; Acyl-CoA dehydrogenase C-terminal domain-like; 1. DR SUPFAM; SSF56645; Acyl-CoA dehydrogenase NM domain-like; 1. PE 3: Inferred from homology; KW FAD {ECO:0000256|ARBA:ARBA00022827}; KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630}. FT DOMAIN 126..213 FT /note="Acyl-CoA_dh_N" FT /evidence="ECO:0000259|Pfam:PF02771" FT DOMAIN 217..307 FT /note="Acyl-CoA_dh_M" FT /evidence="ECO:0000259|Pfam:PF02770" FT DOMAIN 340..483 FT /note="Acyl-CoA_dh_1" FT /evidence="ECO:0000259|Pfam:PF00441" FT DOMAIN 494..772 FT /note="ACDH_C" FT /evidence="ECO:0000259|Pfam:PF09317" SQ SEQUENCE 798 AA; 87457 MW; A330F29B7034B15C CRC64; MNLALSSLLL LAFTAAMGAI GLWTYWMLVP LAIVLLPLNI VSLRRSLLSA PALRAFRKVM PPMSTTEKEA IDAGTTWWEG DLFRGQPDWN KLHNYPQPKL TEEEQAFIDG PVEEACRMAN DFEITHELAD LPPELWAYLK EHRFFAMIIK KEYGGLEFSP YAQARVLQKL AGVSGILAIT VGVPNSLGPG ELLQHYGTEE QKDHYLPGLA RGDEIPCFAL TSPEAGSDAG AIPDVGTVCM GEWQGKQVLG MRLTWNKRYI TLAPIATVLG LAFKLHDPSR LLSDNESPGI TCALIPTNTP GVEIGNRHFP LNVPFQNGPT RGNDVFVPID YIIGGPKMAG QGWRMLVECL SVGRGITLPS NSTGSLKSVA LATGAYAHIR RQFKISIGKM EGIEEPLARI AGNTYVMDAA ASLITYALMQ GEKPAVLSAI VKYHCTHRGQ QAIIDAMDIT GGKGIMLGEA NFLARAYQGA PIAITVEGAN ILTRTMMIFG QGAIRCHPYV LTEMAAAQNN DLHSFDQALF GHLGHVGSSK MRSLWLGLTN GRTSSTPTKD ATRRYYQQLN RLSANLALLS DVSMGVLGGS LKRRERISAR LGDVLSQMYL ASATLKRFED EGRQKEDLPL VHWGVQDSLH QAEQALDDLL RNFPNRFIAG VMRLVVFPFG RVHTAPSDKL DHQLAKIIQQ PSATRSRLGR GQYLTPSEHN PVGLLEAALL DVIAAEPIHQ RLCKQAGKNL PFTRLDRLAQ RALDEGKISA DEAKILVKAE ESRLRSINVD DFAPDALAAQ QPVKPVKLEK RQQQTEAA //