ID U1M141_9BACL Unreviewed; 607 AA. AC U1M141; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 02-JUN-2021, entry version 34. DE RecName: Full=Chaperone protein DnaK {ECO:0000256|ARBA:ARBA00014415, ECO:0000256|HAMAP-Rule:MF_00332}; DE AltName: Full=HSP70 {ECO:0000256|HAMAP-Rule:MF_00332}; DE AltName: Full=Heat shock 70 kDa protein {ECO:0000256|HAMAP-Rule:MF_00332}; DE AltName: Full=Heat shock protein 70 {ECO:0000256|HAMAP-Rule:MF_00332}; GN Name=dnaK {ECO:0000256|HAMAP-Rule:MF_00332, GN ECO:0000313|EMBL:ERG68407.1}; GN ORFNames=M467_14095 {ECO:0000313|EMBL:ERG68407.1}; OS Exiguobacterium chiriqhucha RW-2. OC Bacteria; Firmicutes; Bacilli; Bacillales; OC Bacillales Family XII. Incertae Sedis; Exiguobacterium. OX NCBI_TaxID=1345023 {ECO:0000313|EMBL:ERG68407.1, ECO:0000313|Proteomes:UP000016464}; RN [1] {ECO:0000313|EMBL:ERG68407.1, ECO:0000313|Proteomes:UP000016464} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RW-2 {ECO:0000313|EMBL:ERG68407.1, RC ECO:0000313|Proteomes:UP000016464}; RX PubMed=23929485; RA White R.A.III., Grassa C.J., Suttle C.A.; RT "Draft Genome Sequence of Exiguobacterium pavilionensis Strain RW-2, with RT Wide Thermal, Salinity, and pH Tolerance, Isolated from Modern Freshwater RT Microbialites."; RL Genome Announc. 1:e00597-13(2013). CC -!- FUNCTION: Acts as a chaperone. {ECO:0000256|ARBA:ARBA00002290, CC ECO:0000256|HAMAP-Rule:MF_00332}. CC -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000256|HAMAP- CC Rule:MF_00332}. CC -!- SIMILARITY: Belongs to the heat shock protein 70 family. CC {ECO:0000256|ARBA:ARBA00007381, ECO:0000256|HAMAP-Rule:MF_00332, CC ECO:0000256|RuleBase:RU003322}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:ERG68407.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; ATCL01000009; ERG68407.1; -; Genomic_DNA. DR RefSeq; WP_021065670.1; NZ_ATCL01000009.1. DR STRING; 1345023.M467_14095; -. DR EnsemblBacteria; ERG68407; ERG68407; M467_14095. DR PATRIC; fig|1345023.5.peg.508; -. DR eggNOG; COG0443; Bacteria. DR Proteomes; UP000016464; Unassembled WGS sequence. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0016887; F:ATPase activity; IEA:InterPro. DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro. DR GO; GO:0006457; P:protein folding; IEA:InterPro. DR Gene3D; 1.20.1270.10; -; 1. DR Gene3D; 2.60.34.10; -; 1. DR HAMAP; MF_00332; DnaK; 1. DR InterPro; IPR043129; ATPase_NBD. DR InterPro; IPR012725; Chaperone_DnaK. DR InterPro; IPR018181; Heat_shock_70_CS. DR InterPro; IPR029048; HSP70_C_sf. DR InterPro; IPR029047; HSP70_peptide-bd_sf. DR InterPro; IPR013126; Hsp_70_fam. DR PANTHER; PTHR19375; PTHR19375; 2. DR Pfam; PF00012; HSP70; 2. DR SUPFAM; SSF100920; SSF100920; 1. DR SUPFAM; SSF100934; SSF100934; 1. DR SUPFAM; SSF53067; SSF53067; 2. DR TIGRFAMs; TIGR02350; prok_dnaK; 1. DR PROSITE; PS00297; HSP70_1; 1. DR PROSITE; PS00329; HSP70_2; 1. DR PROSITE; PS01036; HSP70_3; 1. PE 2: Evidence at transcript level; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP- KW Rule:MF_00332}; KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|HAMAP-Rule:MF_00332}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP- KW Rule:MF_00332}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|HAMAP- KW Rule:MF_00332}; KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP- KW Rule:MF_00332}. FT REGION 488..507 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 576..607 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 221..248 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 519..570 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 584..607 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 172 FT /note="Phosphothreonine; by autocatalysis" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00332" SQ SEQUENCE 607 AA; 65314 MW; FB7D9B08B19C4DDB CRC64; MGKIIGIDLG TTNSCVAVME GGEAVVISNA EGNRTTPSVV AFKGEERQVG EVAKRQAITN PNTIQSIKRH MGTSHTVEVD GKKFTPQEIS AIILQKLKKD AEDYLGETVT EAVITVPAYF NDAERQATKD AGKIAGLDVK RIINEPTAAA LAYGLDKGED HTILIYDLGG GTFDVSILEL GDGVFEVVAT AGDNRLGGDD FDQKVIDYLV SEFKKENGID LAQDKMALQR LKDAAEKAKK DLSGVTSAHI SLPFITAGAA GPLHLETTLT RAKFEELTAD LVERTMEPTR RALKDSGLTP SDLDKIILVG GSTRIPAVQK AIHDFTKKEP FKGVNPDEVV ALGAAIQGGV LAGDVKDVVL LDVTPLSLGI ETMGGVMTKL IDRNTTIPTS KSQVFSTAAD SQPAVDIHVL QGERPMAPDN KTLGRFQLTD IPPAPRGVPQ IEVKFDIDAN GIVHVSAKDL GTNKEQSITI QSSSGIDEAE IERMVKEAEA NAEADKQRKE EAELRNETDQ LVFATDKAIK DLGDKVDATD KERAEAAKEK AKTALEGTDL EAIRTAKDEL SNVVQELTQK VYANMAEQQD AESAETQTEA KDDNVVDAEF EDLDDRK //