ID T1QWN6_9PLEU Unreviewed; 234 AA. AC T1QWN6; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 27-NOV-2024, entry version 30. DE SubName: Full=Cardiac muscle myosin heavy chain 6 {ECO:0000313|EMBL:AGD97190.1}; DE Flags: Fragment; GN Name=MYH6 {ECO:0000313|EMBL:AGD97190.1}; OS Lepidoblepharon ophthalmolepis. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Carangaria; Pleuronectiformes; Pleuronectoidei; Citharidae; OC Lepidoblepharon. OX NCBI_TaxID=195621 {ECO:0000313|EMBL:AGD97190.1}; RN [1] {ECO:0000313|EMBL:AGD97190.1} RP NUCLEOTIDE SEQUENCE. RA Betancur R.; RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AGD97190.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=23749787; DOI=10.1093/sysbio/syt039; RA Betancur-R R., Li C., Munroe T.A., Ballesteros J.A., Orti G.; RT "Addressing gene tree discordance and non-stationarity to resolve a multi- RT locus phylogeny of the flatfishes (teleostei: pleuronectiformes)."; RL Syst. Biol. 62:763-785(2013). CC -!- FUNCTION: Muscle contraction. {ECO:0000256|ARBA:ARBA00037488}. CC -!- SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy CC chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 CC regulatory light chain subunits (MLC-2). CC {ECO:0000256|ARBA:ARBA00038612}. CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril CC {ECO:0000256|ARBA:ARBA00004657}. CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JQ939589; AGD97190.1; -; Genomic_DNA. DR AlphaFoldDB; T1QWN6; -. DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter. DR GO; GO:0032982; C:myosin filament; IEA:TreeGrafter. DR GO; GO:0016460; C:myosin II complex; IEA:TreeGrafter. DR GO; GO:0051015; F:actin filament binding; IEA:TreeGrafter. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0000146; F:microfilament motor activity; IEA:TreeGrafter. DR GO; GO:0048731; P:system development; IEA:UniProt. DR FunFam; 1.10.10.820:FF:000001; Myosin heavy chain; 1. DR FunFam; 1.20.120.720:FF:000001; Myosin heavy chain, muscle; 1. DR Gene3D; 1.10.10.820; -; 1. DR Gene3D; 3.40.850.10; Kinesin motor domain; 1. DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1. DR InterPro; IPR036961; Kinesin_motor_dom_sf. DR InterPro; IPR001609; Myosin_head_motor_dom. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1. DR PANTHER; PTHR45615:SF11; MYOSIN-6; 1. DR Pfam; PF00063; Myosin_head; 1. DR SMART; SM00242; MYSc; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR PROSITE; PS51456; MYOSIN_MOTOR; 1. PE 3: Inferred from homology; KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE- KW ProRule:PRU00782}; ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054}; KW Motor protein {ECO:0000256|ARBA:ARBA00023175}; KW Muscle protein {ECO:0000256|ARBA:ARBA00023179}; KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE- KW ProRule:PRU00782}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840}; KW Thick filament {ECO:0000256|ARBA:ARBA00022433}. FT DOMAIN 1..234 FT /note="Myosin motor" FT /evidence="ECO:0000259|PROSITE:PS51456" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AGD97190.1" FT NON_TER 234 FT /evidence="ECO:0000313|EMBL:AGD97190.1" SQ SEQUENCE 234 AA; 26032 MW; DCB98DF5AA5D3F5E CRC64; KTVNTKRVIQ YFASIAAVGG GSQKDTSKGT LEDQIIQANP ALEAFGNAKT LRNDNSSRFG KFIRIHFGTS GKLSSADIET YLLEKSRVTF QLKAERNYHI FYQILSNQKP ELLDMLLITN NPYDYSYISQ GEVTVASIND SEELMATDSA FDVLGFTPEE KMGVYKLTGA IMHYGNMKFK QKQREEQAEP DGTESADKSA YLMGLNSADL IKGLCHPRVK VGNEYVTKGQ SVDQ //