ID   T1H9J5_RHOPR            Unreviewed;       442 AA.
AC   T1H9J5;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JUL-2024, entry version 53.
DE   RecName: Full=Semialdehyde dehydrogenase NAD-binding domain-containing protein {ECO:0000259|SMART:SM00859};
OS   Rhodnius prolixus (Triatomid bug).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC   Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX   NCBI_TaxID=13249 {ECO:0000313|EnsemblMetazoa:RPRC000698-PA, ECO:0000313|Proteomes:UP000015103};
RN   [1] {ECO:0000313|Proteomes:UP000015103}
RP   NUCLEOTIDE SEQUENCE.
RA   Wilson R.K., Warren W., Dotson E., Oliveira P.L.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:RPRC000698-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2015) to UniProtKB.
CC   -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
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DR   EMBL; ACPB03027601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; T1H9J5; -.
DR   STRING; 13249.T1H9J5; -.
DR   EnsemblMetazoa; RPRC000698-RA; RPRC000698-PA; RPRC000698.
DR   VEuPathDB; VectorBase:RPRC000698; -.
DR   eggNOG; KOG2436; Eukaryota.
DR   eggNOG; KOG4354; Eukaryota.
DR   HOGENOM; CLU_034998_0_0_1; -.
DR   InParanoid; T1H9J5; -.
DR   OrthoDB; 987250at2759; -.
DR   Proteomes; UP000015103; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0003991; F:acetylglutamate kinase activity; IEA:InterPro.
DR   GO; GO:0003942; F:N-acetyl-gamma-glutamyl-phosphate reductase activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd04249; AAK_NAGK-NC; 1.
DR   Gene3D; 3.40.1160.10; Acetylglutamate kinase-like; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   HAMAP; MF_00082; ArgB; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR004662; AcgluKinase_fam.
DR   InterPro; IPR023013; AGPR_AS.
DR   InterPro; IPR037528; ArgB.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR041731; NAGK-NC.
DR   InterPro; IPR050085; NAGSA_dehydrogenase.
DR   InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR   NCBIfam; TIGR00761; argB; 1.
DR   PANTHER; PTHR32338:SF10; N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED; 1.
DR   PANTHER; PTHR32338; N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED-RELATED; 1.
DR   Pfam; PF00696; AA_kinase; 1.
DR   Pfam; PF01118; Semialdhyde_dh; 1.
DR   SMART; SM00859; Semialdhyde_dh; 1.
DR   SUPFAM; SSF53633; Carbamate kinase-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS01224; ARGC; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW   Arginine biosynthesis {ECO:0000256|ARBA:ARBA00022571};
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015103}.
FT   DOMAIN          1..120
FT                   /note="Semialdehyde dehydrogenase NAD-binding"
FT                   /evidence="ECO:0000259|SMART:SM00859"
SQ   SEQUENCE   442 AA;  46575 MW;  2D868AEE10FD67F5 CRC64;
     MNLTALAVSA QSVDAGKRIS DLHPQLKGII DLPVQALTDA AEAAKGIDVV FLATDHKVSH
     DLAPVFLAAG CVVFDLSGAF RVQDAEFYRR YYGFEHQHAD WLAQAVYGLA EFQAERVKQA
     QLIAVPGCYP TASQLALKPL VDAQLLNTDL WPVINAVSGV SGAGRKASLT SSFCEVSLQP
     YGTKAMNPLI IKLGGVLLDS EEALERLFTA LVAYREQYQR PLVIVHGGGC LVDDLMKKLA
     LPVVKKNGLR VTPADQIDII TGALAGSANK TLLAWAKKHA INAVGLCLVD GGMSTVTQLD
     ESLGYVGKAQ AGSADLPNAL LSAGYLPIVS SIGITEQGDL MNVNADQAAT ALAETLGADL
     ILLSDVSGIL DAKGQRIAEM TAQKAEQLIA KGIITDGMIV KVNAALDAAR ALGRPVDIAS
     WRHADQLPAL FNGTPIGTRI LA
//