ID T0YDS3_9ZZZZ Unreviewed; 200 AA. AC T0YDS3; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 24-JAN-2024, entry version 14. DE RecName: Full=7-cyano-7-deazaguanine synthase {ECO:0000256|ARBA:ARBA00039149}; DE EC=6.3.4.20 {ECO:0000256|ARBA:ARBA00039149}; DE Flags: Fragment; GN ORFNames=B1A_20002 {ECO:0000313|EMBL:EQD31308.1}; OS mine drainage metagenome. OC unclassified sequences; metagenomes; ecological metagenomes. OX NCBI_TaxID=410659 {ECO:0000313|EMBL:EQD31308.1}; RN [1] {ECO:0000313|EMBL:EQD31308.1} RP NUCLEOTIDE SEQUENCE. RA Mendez C., Richter M., Ferrer M., Sanchez J.; RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:EQD31308.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24430486; DOI=10.1038/ismej.2013.242; RA Mendez-Garcia C., Mesa V., Sprenger R.R., Richter M., Diez M.S., Solano J., RA Bargiela R., Golyshina O.V., Manteca A., Ramos J.L., Gallego J.R., RA Llorente I., Martins Dos Santos V.A., Jensen O.N., Pelaez A.I., Sanchez J., RA Ferrer M.; RT "Microbial stratification in low pH oxic and suboxic macroscopic growths RT along an acid mine drainage."; RL ISME J. 8:1259-1274(2014). CC -!- CATALYTIC ACTIVITY: CC Reaction=7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7- CC deazaguanine + ADP + H(+) + H2O + phosphate; Xref=Rhea:RHEA:27982, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:45075, CC ChEBI:CHEBI:61036, ChEBI:CHEBI:456216; EC=6.3.4.20; CC Evidence={ECO:0000256|ARBA:ARBA00037008}; CC -!- PATHWAY: Purine metabolism; 7-cyano-7-deazaguanine biosynthesis. CC {ECO:0000256|ARBA:ARBA00005061}. CC -!- SIMILARITY: Belongs to the QueC family. CC {ECO:0000256|ARBA:ARBA00037993}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:EQD31308.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AUZX01014760; EQD31308.1; -; Genomic_DNA. DR AlphaFoldDB; T0YDS3; -. DR CDD; cd01995; ExsB; 1. DR Gene3D; 3.40.50.620; HUPs; 1. DR HAMAP; MF_01633; QueC; 1. DR InterPro; IPR018317; QueC. DR InterPro; IPR014729; Rossmann-like_a/b/a_fold. DR NCBIfam; TIGR00364; 7-cyano-7-deazaguanine synthase QueC; 1. DR PANTHER; PTHR42914; 7-CYANO-7-DEAZAGUANINE SYNTHASE; 1. DR PANTHER; PTHR42914:SF1; 7-CYANO-7-DEAZAGUANINE SYNTHASE; 1. DR Pfam; PF06508; QueC; 1. DR PIRSF; PIRSF006293; ExsB; 1. DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1. PE 3: Inferred from homology; FT NON_TER 200 FT /evidence="ECO:0000313|EMBL:EQD31308.1" SQ SEQUENCE 200 AA; 21634 MW; 0393C5B26FD3CB55 CRC64; MMNGTSTTKR AVVLLSGGLD SATVLAVAKH QGFTCYALSF DYGQRHRQEL LAAAELAKAM GVVEHVILNL NLRHFGGSAL TADIAVPKDR PAAAMADGIP VTYVPARNTV FLSCALAWAE VLECFDIFIG VNAVDYSGYP DCRPGYISAF EQMANLATRA GIEGRGKFTI HSPLMELQKV GIIRLGRSLE IDYGKTWTCY //