ID S9YUF5_CAMFR Unreviewed; 189 AA. AC S9YUF5; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 22-FEB-2023, entry version 32. DE RecName: Full=Homeobox protein prophet of Pit-1 {ECO:0000256|ARBA:ARBA00019432}; DE AltName: Full=Pituitary-specific homeodomain factor {ECO:0000256|ARBA:ARBA00030888}; GN ORFNames=CB1_000228028 {ECO:0000313|EMBL:EPY87665.1}; OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus. OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY87665.1, ECO:0000313|Proteomes:UP000030684}; RN [1] {ECO:0000313|EMBL:EPY87665.1, ECO:0000313|Proteomes:UP000030684} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684}; RX PubMed=23149746; RG Bactrian Camels Genome Sequencing and Analysis Consortium; RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L., RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W., RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H., RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu, RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha, RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A., RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y., RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J., RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T., RA Bayaer T., Li Y., Meng H.; RT "Genome sequences of wild and domestic bactrian camels."; RL Nat. Commun. 3:1202-1202(2012). CC -!- FUNCTION: Possibly involved in the ontogenesis of pituitary CC gonadotropes, as well as somatotropes, lactotropes and caudomedial CC thyrotropes. {ECO:0000256|ARBA:ARBA00002030}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108, CC ECO:0000256|RuleBase:RU000682}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KB016521; EPY87665.1; -; Genomic_DNA. DR AlphaFoldDB; S9YUF5; -. DR Proteomes; UP000030684; Unassembled WGS sequence. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro. DR GO; GO:0021983; P:pituitary gland development; IEA:InterPro. DR CDD; cd00086; homeodomain; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR042412; PROP1. DR PANTHER; PTHR47409; HOMEOBOX PROTEIN PROPHET OF PIT-1; 1. DR PANTHER; PTHR47409:SF1; HOMEOBOX PROTEIN PROPHET OF PIT-1; 1. DR Pfam; PF00046; Homeodomain; 1. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 4: Predicted; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE- KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000030684}. FT DOMAIN 30..90 FT /note="Homeobox" FT /evidence="ECO:0000259|PROSITE:PS50071" FT DNA_BIND 32..91 FT /note="Homeobox" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108" FT REGION 1..51 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 162..189 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 166..182 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 189 AA; 21015 MW; F03C7C843277542F CRC64; MSARPYRNLS GAGAGRPRPS PPGGQRARPH SRRRHRTTFS PAQLEQLESA FGRNQYPDIW AREGLARDTG LSEARIQVWF QNRRAKQRKQ ERSLLQPLAR LSPAAFSGFL PEPPACPYPY PTPPPPVACF PHPYNHALPT QPPTGGSFAR AHQSEDWFPA LHATPAGHLP CPPPPPRLPL SLEPPKSWN //