ID   S9XV34_CAMFR            Unreviewed;       278 AA.
AC   S9XV34;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JUL-2024, entry version 33.
DE   SubName: Full=Cathepsin L1 isoform 1 preproprotein {ECO:0000313|EMBL:EPY78946.1};
GN   ORFNames=CB1_000978017 {ECO:0000313|EMBL:EPY78946.1};
OS   Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX   NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY78946.1, ECO:0000313|Proteomes:UP000030684};
RN   [1] {ECO:0000313|EMBL:EPY78946.1, ECO:0000313|Proteomes:UP000030684}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX   PubMed=23149746;
RG   Bactrian Camels Genome Sequencing and Analysis Consortium;
RA   Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA   Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA   Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA   Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA   Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA   Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA   Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA   Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA   Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA   Bayaer T., Li Y., Meng H.;
RT   "Genome sequences of wild and domestic bactrian camels.";
RL   Nat. Commun. 3:1202-1202(2012).
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
CC       {ECO:0000256|ARBA:ARBA00008455, ECO:0000256|PROSITE-ProRule:PRU10090}.
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DR   EMBL; KB017216; EPY78946.1; -; Genomic_DNA.
DR   AlphaFoldDB; S9XV34; -.
DR   MEROPS; C01.032; -.
DR   Proteomes; UP000030684; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; IEA:TreeGrafter.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:TreeGrafter.
DR   GO; GO:0006955; P:immune response; IEA:TreeGrafter.
DR   GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; IEA:TreeGrafter.
DR   GO; GO:0051603; P:proteolysis involved in protein catabolic process; IEA:TreeGrafter.
DR   CDD; cd02248; Peptidase_C1A; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR025661; Pept_asp_AS.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR025660; Pept_his_AS.
DR   InterPro; IPR013128; Peptidase_C1A.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR039417; Peptidase_C1A_papain-like.
DR   InterPro; IPR013201; Prot_inhib_I29.
DR   PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR   PANTHER; PTHR12411:SF902; PROCATHEPSIN L; 1.
DR   Pfam; PF08246; Inhibitor_I29; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   PRINTS; PR00705; PAPAIN.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU10090}; Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU10090}; Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW   Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW   ProRule:PRU10090}; Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT   DOMAIN          59..277
FT                   /note="Peptidase C1A papain C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00645"
FT   ACT_SITE        245
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10090"
SQ   SEQUENCE   278 AA;  30923 MW;  91250B591593149E CRC64;
     MKIIELHNRE YRQRKHSFTM AMNAFGDMTR REFRQAMNSF QNKKSKMGKM FPVAVDASIP
     ASLDWREKGY VTPVKNQGPC GSCWAFSATG ALEGQMFRKT GKLVSLSEQN LVDCSWPQGN
     EGCNGGLMDY AFQYVKDNGG LDSEKSYPYS GKDETCHYRP QDSAANDTGF MDIPKEEKAL
     LNAVASVGPI SVGIDASLTS FQFYKKGIYY DPDCSTENLD HGVLLVGYGF EGQGTNNDKY
     WLVKNSWGEG WGMKGYIKMA KDRNNHCGIA SAASFPTV
//