ID S9WAS1_CAMFR Unreviewed; 133 AA. AC S9WAS1; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 27-MAR-2024, entry version 38. DE RecName: Full=E2 ubiquitin-conjugating enzyme {ECO:0000256|ARBA:ARBA00012486}; DE EC=2.3.2.23 {ECO:0000256|ARBA:ARBA00012486}; GN ORFNames=CB1_002920001 {ECO:0000313|EMBL:EPY73508.1}; OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus. OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY73508.1, ECO:0000313|Proteomes:UP000030684}; RN [1] {ECO:0000313|EMBL:EPY73508.1, ECO:0000313|Proteomes:UP000030684} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684}; RX PubMed=23149746; RG Bactrian Camels Genome Sequencing and Analysis Consortium; RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L., RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W., RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H., RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu, RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha, RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A., RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y., RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J., RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T., RA Bayaer T., Li Y., Meng H.; RT "Genome sequences of wild and domestic bactrian camels."; RL Nat. Commun. 3:1202-1202(2012). CC -!- CATALYTIC ACTIVITY: CC Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + CC [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- CC activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- CC conjugating enzyme]-L-cysteine.; EC=2.3.2.23; CC Evidence={ECO:0000256|ARBA:ARBA00000485}; CC -!- PATHWAY: Protein modification. {ECO:0000256|ARBA:ARBA00043952}. CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. CC {ECO:0000256|RuleBase:RU362109}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KB018660; EPY73508.1; -; Genomic_DNA. DR AlphaFoldDB; S9WAS1; -. DR Proteomes; UP000030684; Unassembled WGS sequence. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW. DR CDD; cd00195; UBCc; 1. DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1. DR InterPro; IPR000608; UBQ-conjugat_E2. DR InterPro; IPR023313; UBQ-conjugating_AS. DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD. DR PANTHER; PTHR24068; UBIQUITIN-CONJUGATING ENZYME E2; 1. DR PANTHER; PTHR24068:SF152; UBIQUITIN-CONJUGATING ENZYME E2 N; 1. DR Pfam; PF00179; UQ_con; 1. DR SMART; SM00212; UBCc; 1. DR SUPFAM; SSF54495; UBC-like; 1. DR PROSITE; PS00183; UBC_1; 1. DR PROSITE; PS50127; UBC_2; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|RuleBase:RU362109}; KW Nucleotide-binding {ECO:0000256|RuleBase:RU362109}; KW Reference proteome {ECO:0000313|Proteomes:UP000030684}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786, KW ECO:0000256|RuleBase:RU362109}. FT DOMAIN 1..133 FT /note="UBC core" FT /evidence="ECO:0000259|PROSITE:PS50127" FT ACT_SITE 79 FT /note="Glycyl thioester intermediate" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10133" SQ SEQUENCE 133 AA; 14870 MW; D0FAFA68C0BC227F CRC64; MEETQRLLAE PVPGIKAEPD ESNARYFHVV IAGPQDSPFE GGTFKLELFL PEEYPMAAPK VRFMTKIYHP NVDKLGRICL DILKDKWSPA LQIRTVLLSI QALLSAPNPD DPLANDVAEQ WKTNEAQAIE TGI //