ID S5TUE5_ENTCL Unreviewed; 546 AA. AC S5TUE5; A0A0P8I575; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 29-SEP-2021, entry version 65. DE RecName: Full=60 kDa chaperonin {ECO:0000256|HAMAP-Rule:MF_00600, ECO:0000256|RuleBase:RU000419}; DE AltName: Full=GroEL protein {ECO:0000256|HAMAP-Rule:MF_00600}; DE AltName: Full=Protein Cpn60 {ECO:0000256|HAMAP-Rule:MF_00600}; GN Name=groEL {ECO:0000256|HAMAP-Rule:MF_00600, GN ECO:0000313|EMBL:AGS56781.1}; GN Synonyms=groL {ECO:0000256|HAMAP-Rule:MF_00600, GN ECO:0000313|EMBL:AHN60531.1}; GN ORFNames=pCRE727_16 {ECO:0000313|EMBL:AHN60531.1}, pNDM1_EC14653_00120 GN {ECO:0000313|EMBL:AKN19823.1}, pYQ13500_017 GN {ECO:0000313|EMBL:AKP49212.1}; OS Enterobacter cloacae. OG Plasmid pCR16-ECL-NDM-1 {ECO:0000313|EMBL:AKN35257.1}, OG Plasmid pECL3-NDM-1 {ECO:0000313|EMBL:AGS56781.1}, OG Plasmid pNDM-ECN49 {ECO:0000313|EMBL:AKJ21421.1}, OG Plasmid pNDM-Ec1GN574 {ECO:0000313|EMBL:AIM48565.1}, OG Plasmid pNDM-HF727 {ECO:0000313|EMBL:AHN60531.1}, OG Plasmid pNDM1_EC14653 {ECO:0000313|EMBL:AKN19823.1}, OG Plasmid pPN2-ECL-NDM-1 {ECO:0000313|EMBL:ALD19765.1}, and OG Plasmid pYQ13500-NDM {ECO:0000313|EMBL:AKP49212.1}. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex. OX NCBI_TaxID=550 {ECO:0000313|EMBL:AGS56781.1}; RN [1] {ECO:0000313|EMBL:AHN60531.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CRE727 {ECO:0000313|EMBL:AHN60531.1}; RC PLASMID=pNDM-HF727 {ECO:0000313|EMBL:AHN60531.1}; RA Ho P.L., Li Z., Lo W.U., Cheung Y.Y., Lin C.H., Sham P.C., Cheng V.C.C., RA Ng T.K., Que T.L., Chow K.H.; RT "Identification and characterization of a novel incompatibility group X3 RT plasmid carrying blaNDM-1 in Enterobacteriaceae isolates with RT epidemiological links to multiple geographical areas in China."; RL Emerg. Microbes Infect. 1:e39-e39(2012). RN [2] {ECO:0000313|EMBL:AHN60531.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CRE727 {ECO:0000313|EMBL:AHN60531.1}; RC PLASMID=pNDM-HF727 {ECO:0000313|EMBL:AHN60531.1}; RA Ho P.L., Lo W.U., Li Z., Chow K.H., Lin C.H., Chan W.; RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:AIM48565.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=GN574 {ECO:0000313|EMBL:AIM48565.1}; RC PLASMID=pNDM-Ec1GN574 {ECO:0000313|EMBL:AIM48565.1}; RX PubMed=25845877; DOI=10.1128/AAC.04862-14; RA Tijet N., Richardson D., MacMullin G., Patel S.N., Melano R.G.; RT "Characterization of multiple NDM-1-producing Enterobacteriaceae isolates RT from the same patient."; RL Antimicrob. Agents Chemother. 59:3648-3651(2015). RN [4] {ECO:0000313|EMBL:AKN19823.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=WCHECl-14653 {ECO:0000313|EMBL:AKN19823.1}; RC PLASMID=pNDM1_EC14653 {ECO:0000313|EMBL:AKN19823.1}; RX PubMed=26248381; DOI=10.1128/AAC.01275-15; RA Wu W., Feng Y., Carattoli A., Zong Z.; RT "Characterization of an Enterobacter cloacae Strain Producing both KPC and RT NDM Carbapenemases by Whole-Genome Sequencing."; RL Antimicrob. Agents Chemother. 59:6625-6628(2015). RN [5] {ECO:0000313|EMBL:AKP49212.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=EC-YQ13500 {ECO:0000313|EMBL:AKP49212.1}; RC PLASMID=pYQ13500-NDM {ECO:0000313|EMBL:AKP49212.1}; RX PubMed=26047502; RA Yang Q., Fang L., Fu Y., Du X., Shen Y., Yu Y.; RT "Dissemination of NDM-1-Producing Enterobacteriaceae Mediated by the IncX3- RT Type Plasmid."; RL PLoS ONE 10:E0129454-E0129454(2015). RN [6] {ECO:0000313|EMBL:AKN35257.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CR16 {ECO:0000313|EMBL:AKN35257.1}; RC PLASMID=pCR16-ECL-NDM-1 {ECO:0000313|EMBL:AKN35257.1}; RA Wailan A.M., Paterson D.L., Kennedy K., Ingram P., Paterson D.L., RA Sidjabat H.E.; RT "Genomic characteristics of NDM-producing Enterobacteriaceae in Australia RT and their blaNDM genetic contexts."; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:ALD19765.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Pn2 {ECO:0000313|EMBL:ALD19765.1}; RC PLASMID=pPN2-ECL-NDM-1 {ECO:0000313|EMBL:ALD19765.1}; RA Wailan A.M., Sartor A.L., Zowawi H.M., Perry J.D., Paterson D.L., RA Sidjabat H.E.; RT "The genetic characterization of NDM-1 producing Enterobacteriaceae and RT Acinetobacter baumannii from Pakistan hospitals for an insight of blaNDM RT acquisition via plasmids."; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:AKJ21421.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ECN49 {ECO:0000313|EMBL:AKJ21421.1}; RC PLASMID=pNDM-ECN49 {ECO:0000313|EMBL:AKJ21421.1}; RA Zhao X.J., Ma P.; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AGS56781.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ECL3 {ECO:0000313|EMBL:AGS56781.1}; RC PLASMID=pECL3-NDM-1 {ECO:0000313|EMBL:AGS56781.1}; RX PubMed=27114281; RA Wailan A.M., Sidjabat H.E., Yam W.K., Alikhan N.F., Petty N.K., RA Sartor A.L., Williamson D.A., Forde B.M., Schembri M.A., Beatson S.A., RA Paterson D.L., Walsh T.R., Partridge S.R.; RT "Mechanisms involved in acquisition of blaNDM genes by IncA/C2 and IncFIIY RT plasmids."; RL Antimicrob. Agents Chemother. 0:0-0(2016). CC -!- FUNCTION: Prevents misfolding and promotes the refolding and proper CC assembly of unfolded polypeptides generated under stress conditions. CC {ECO:0000256|HAMAP-Rule:MF_00600, ECO:0000256|RuleBase:RU000419}. CC -!- SUBUNIT: Oligomer of 14 subunits composed of two stacked rings of 7 CC subunits. {ECO:0000256|HAMAP-Rule:MF_00600, CC ECO:0000256|RuleBase:RU000419}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00600}. CC -!- SIMILARITY: Belongs to the chaperonin (HSP60) family. CC {ECO:0000256|ARBA:ARBA00006607, ECO:0000256|HAMAP-Rule:MF_00600, CC ECO:0000256|RuleBase:RU000418}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KC887917; AGS56781.1; -; Genomic_DNA. DR EMBL; KF976405; AHN60531.1; -; Genomic_DNA. DR EMBL; KJ812998; AIM48565.1; -; Genomic_DNA. DR EMBL; KP765744; AKJ21421.1; -; Genomic_DNA. DR EMBL; KP868647; AKN19823.1; -; Genomic_DNA. DR EMBL; KP826704; AKN35257.1; -; Genomic_DNA. DR EMBL; KR059865; AKP49212.1; -; Genomic_DNA. DR EMBL; KP770024; ALD19765.1; -; Genomic_DNA. DR RefSeq; WP_004201176.1; NZ_RXQP01000050.1. DR RefSeq; YP_009023656.1; NC_023914.1. DR GeneID; 59688582; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule. DR GO; GO:0042026; P:protein refolding; IEA:UniProtKB-UniRule. DR CDD; cd03344; GroEL; 1. DR Gene3D; 1.10.560.10; -; 1. DR Gene3D; 3.30.260.10; -; 1. DR Gene3D; 3.50.7.10; -; 1. DR HAMAP; MF_00600; CH60; 1. DR InterPro; IPR018370; Chaperonin_Cpn60_CS. DR InterPro; IPR001844; Chaprnin_Cpn60. DR InterPro; IPR002423; Cpn60/TCP-1. DR InterPro; IPR027409; GroEL-like_apical_dom_sf. DR InterPro; IPR027413; GROEL-like_equatorial_sf. DR InterPro; IPR027410; TCP-1-like_intermed_sf. DR Pfam; PF00118; Cpn60_TCP1; 1. DR PRINTS; PR00298; CHAPERONIN60. DR SUPFAM; SSF48592; SSF48592; 1. DR SUPFAM; SSF52029; SSF52029; 1. DR SUPFAM; SSF54849; SSF54849; 1. DR TIGRFAMs; TIGR02348; GroEL; 1. DR PROSITE; PS00296; CHAPERONINS_CPN60; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP- KW Rule:MF_00600}; KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|HAMAP-Rule:MF_00600}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00600}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP- KW Rule:MF_00600}; Plasmid {ECO:0000313|EMBL:AGS56781.1}; KW Stress response {ECO:0000313|EMBL:AGS56781.1}. FT REGION 527..546 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 346..366 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 546 AA; 57062 MW; 4E48091CE2FC367A CRC64; MAAKDIRFGE DARSKMVRGV NVLANAVKAT LGPKGRNVVL QKSYGAPTIT KDGVSVAKEI ELADAFENMG AQMVKEVASK TSDNAGDGTT TATVLAQAFI REGMKAVAAG MNPMDLKRGI DQAVKAAVGE LKSLSKPSST SKEIAQVGAI SANSDANIGD LIAQAMDKVG KEGVITVEEG SGLDNELDVV EGMQFDRGYL SPYFVNNQQS MSADLDDPFI LLYDKKISNV RDLLPVLEGV AKAGKPLLIV AEEVEGEALA TLVVNTIRGI VKVCAVKAPG FGDRRKAMLE DMAILTGGVV ISEEVGLSLE KATIKDLGRA KKIQVSKENT TIIDGAGEGA GIEARIKQIK AQIEETSSDY DREKLQERVA KLAGGVAVIK VGAATEVEMK EKKARVEDAL HATRAAVEEG IVPGGGVALI RAKAAIAGIK GVNEDQNHGI QIALRAMEAP LREIVTNAGD EPSVILNRVV EGSGAFGYNA ANGEFGDMIE FGILDPTKVT RTALQNAASI AGLMITTEAM VAEAPKKDEP AMPAGGGMGG MGGMDF //