ID S5TUE5_ENTCL Unreviewed; 546 AA. AC S5TUE5; A0A0P8I575; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 07-SEP-2016, entry version 28. DE RecName: Full=60 kDa chaperonin {ECO:0000256|HAMAP-Rule:MF_00600, ECO:0000256|RuleBase:RU000419}; DE AltName: Full=GroEL protein {ECO:0000256|HAMAP-Rule:MF_00600}; DE AltName: Full=Protein Cpn60 {ECO:0000256|HAMAP-Rule:MF_00600}; GN Name=groEL {ECO:0000256|HAMAP-Rule:MF_00600, GN ECO:0000313|EMBL:AGS56781.1}; GN Synonyms=groL {ECO:0000256|HAMAP-Rule:MF_00600, GN ECO:0000313|EMBL:AHN60531.1}; GN ORFNames=AN674_27015 {ECO:0000313|EMBL:KPR62092.1}, AWS52_24670 GN {ECO:0000313|EMBL:KVI49584.1}, pCRE727_16 GN {ECO:0000313|EMBL:AHN60531.1}, pNDM1_EC14653_00120 GN {ECO:0000313|EMBL:AKN19823.1}, pYQ13500_017 GN {ECO:0000313|EMBL:AKP49212.1}; OS Enterobacter cloacae. OG Plasmid pCR16-ECL-NDM-1 {ECO:0000313|EMBL:AKN35257.1}, OG Plasmid pECL3-NDM-1 {ECO:0000313|EMBL:AGS56781.1}, OG Plasmid pNDM-ECN49 {ECO:0000313|EMBL:AKJ21421.1}, OG Plasmid pNDM-Ec1GN574 {ECO:0000313|EMBL:AIM48565.1}, OG Plasmid pNDM-HF727 {ECO:0000313|EMBL:AHN60531.1}, OG Plasmid pNDM1_EC14653 {ECO:0000313|EMBL:AKN19823.1}, OG Plasmid pPN2-ECL-NDM-1 {ECO:0000313|EMBL:ALD19765.1}, and OG Plasmid pYQ13500-NDM {ECO:0000313|EMBL:AKP49212.1}. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex. OX NCBI_TaxID=550 {ECO:0000313|EMBL:AGS56781.1}; RN [1] {ECO:0000313|EMBL:AHN60531.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CRE727 {ECO:0000313|EMBL:AHN60531.1}; RC PLASMID=pNDM-HF727 {ECO:0000313|EMBL:AHN60531.1}; RA Ho P.L., Li Z., Lo W.U., Cheung Y.Y., Lin C.H., Sham P.C., RA Cheng V.C.C., Ng T.K., Que T.L., Chow K.H.; RT "Identification and characterization of a novel incompatibility group RT X3 plasmid carrying blaNDM-1 in Enterobacteriaceae isolates with RT epidemiological links to multiple geographical areas in China."; RL Emerg. Microbes Infect. 1:e39-e39(2012). RN [2] {ECO:0000313|EMBL:AHN60531.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CRE727 {ECO:0000313|EMBL:AHN60531.1}; RC PLASMID=pNDM-HF727 {ECO:0000313|EMBL:AHN60531.1}; RA Ho P.L., Lo W.U., Li Z., Chow K.H., Lin C.H., Chan W.; RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:AIM48565.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=GN574 {ECO:0000313|EMBL:AIM48565.1}; RC PLASMID=pNDM-Ec1GN574 {ECO:0000313|EMBL:AIM48565.1}; RX PubMed=25845877; DOI=10.1128/AAC.04862-14; RA Tijet N., Richardson D., MacMullin G., Patel S.N., Melano R.G.; RT "Characterization of multiple NDM-1-producing Enterobacteriaceae RT isolates from the same patient."; RL Antimicrob. Agents Chemother. 59:3648-3651(2015). RN [4] {ECO:0000313|EMBL:AKN19823.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=WCHECl-14653 {ECO:0000313|EMBL:AKN19823.1}; RC PLASMID=pNDM1_EC14653 {ECO:0000313|EMBL:AKN19823.1}; RX PubMed=26248381; DOI=10.1128/AAC.01275-15; RA Wu W., Feng Y., Carattoli A., Zong Z.; RT "Characterization of an Enterobacter cloacae Strain Producing both KPC RT and NDM Carbapenemases by Whole-Genome Sequencing."; RL Antimicrob. Agents Chemother. 59:6625-6628(2015). RN [5] {ECO:0000313|EMBL:AKP49212.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=EC-YQ13500 {ECO:0000313|EMBL:AKP49212.1}; RC PLASMID=pYQ13500-NDM {ECO:0000313|EMBL:AKP49212.1}; RX PubMed=26047502; RA Yang Q., Fang L., Fu Y., Du X., Shen Y., Yu Y.; RT "Dissemination of NDM-1-Producing Enterobacteriaceae Mediated by the RT IncX3-Type Plasmid."; RL PLoS ONE 10:E0129454-E0129454(2015). RN [6] {ECO:0000313|EMBL:AKN35257.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CR16 {ECO:0000313|EMBL:AKN35257.1}; RC PLASMID=pCR16-ECL-NDM-1 {ECO:0000313|EMBL:AKN35257.1}; RA Wailan A.M., Paterson D.L., Kennedy K., Ingram P., Paterson D.L., RA Sidjabat H.E.; RT "Genomic characteristics of NDM-producing Enterobacteriaceae in RT Australia and their blaNDM genetic contexts."; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:ALD19765.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Pn2 {ECO:0000313|EMBL:ALD19765.1}; RC PLASMID=pPN2-ECL-NDM-1 {ECO:0000313|EMBL:ALD19765.1}; RA Wailan A.M., Sartor A.L., Zowawi H.M., Perry J.D., Paterson D.L., RA Sidjabat H.E.; RT "The genetic characterization of NDM-1 producing Enterobacteriaceae RT and Acinetobacter baumannii from Pakistan hospitals for an insight of RT blaNDM acquisition via plasmids."; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:AKJ21421.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ECN49 {ECO:0000313|EMBL:AKJ21421.1}; RC PLASMID=pNDM-ECN49 {ECO:0000313|EMBL:AKJ21421.1}; RA Chooi Y.-H.; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:KPR62092.1, ECO:0000313|Proteomes:UP000050321} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ST54:941713674 {ECO:0000313|EMBL:KPR62092.1, RC ECO:0000313|Proteomes:UP000050321}; RA Osei Sekyere J., Govinden U., Essack S., Haldorsen B., Samuelsen O., RA Aasnaes B., Sundsfjord A.; RT "Prevalence of NDMs in South Africa."; RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:AGS56781.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ECL3 {ECO:0000313|EMBL:AGS56781.1}; RC PLASMID=pECL3-NDM-1 {ECO:0000313|EMBL:AGS56781.1}; RX PubMed=27114281; RA Wailan A.M., Sidjabat H.E., Yam W.K., Alikhan N.F., Petty N.K., RA Sartor A.L., Williamson D.A., Forde B.M., Schembri M.A., Beatson S.A., RA Paterson D.L., Walsh T.R., Partridge S.R.; RT "Mechanisms involved in acquisition of blaNDM genes by IncA/C2 and RT IncFIIY plasmids."; RL Antimicrob. Agents Chemother. 0:0-0(2016). RN [11] {ECO:0000313|EMBL:KVI49584.1, ECO:0000313|Proteomes:UP000059440} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SMART_1493 {ECO:0000313|EMBL:KVI49584.1, RC ECO:0000313|Proteomes:UP000059440}; RA McClelland M., Jain A., Saraogi P., Mendelson R., Westerman R., RA SanMiguel P., Csonka L.; RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Prevents misfolding and promotes the refolding and CC proper assembly of unfolded polypeptides generated under stress CC conditions. {ECO:0000256|HAMAP-Rule:MF_00600, CC ECO:0000256|RuleBase:RU000419}. CC -!- SUBUNIT: Oligomer of 14 subunits composed of two stacked rings of CC 7 subunits. {ECO:0000256|HAMAP-Rule:MF_00600, CC ECO:0000256|RuleBase:RU000419}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00600}. CC -!- SIMILARITY: Belongs to the chaperonin (HSP60) family. CC {ECO:0000256|HAMAP-Rule:MF_00600, ECO:0000256|RuleBase:RU000418}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KC887917; AGS56781.1; -; Genomic_DNA. DR EMBL; KF976405; AHN60531.1; -; Genomic_DNA. DR EMBL; KJ812998; AIM48565.1; -; Genomic_DNA. DR EMBL; KP765744; AKJ21421.1; -; Genomic_DNA. DR EMBL; KP868647; AKN19823.1; -; Genomic_DNA. DR EMBL; KP826704; AKN35257.1; -; Genomic_DNA. DR EMBL; KR059865; AKP49212.1; -; Genomic_DNA. DR EMBL; KP770024; ALD19765.1; -; Genomic_DNA. DR EMBL; LJED01000313; KPR62092.1; -; Genomic_DNA. DR EMBL; LRIO01000155; KVI49584.1; -; Genomic_DNA. DR RefSeq; WP_004201176.1; NZ_LRJS01000054.1. DR RefSeq; YP_009023656.1; NC_023914.1. DR EnsemblBacteria; KPR62092; KPR62092; AN674_27015. DR GeneID; 18983793; -. DR KEGG; pg:18983793; -. DR KO; K04077; -. DR Proteomes; UP000050321; Unassembled WGS sequence. DR Proteomes; UP000059440; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP. DR GO; GO:0042026; P:protein refolding; IEA:UniProtKB-HAMAP. DR Gene3D; 1.10.560.10; -; 2. DR Gene3D; 3.50.7.10; -; 1. DR HAMAP; MF_00600; CH60; 1. DR InterPro; IPR018370; Chaperonin_Cpn60_CS. DR InterPro; IPR001844; Chaprnin_Cpn60. DR InterPro; IPR002423; Cpn60/TCP-1. DR InterPro; IPR027409; GroEL-like_apical_dom. DR InterPro; IPR027413; GROEL-like_equatorial. DR Pfam; PF00118; Cpn60_TCP1; 1. DR PRINTS; PR00298; CHAPERONIN60. DR SUPFAM; SSF52029; SSF52029; 1. DR TIGRFAMs; TIGR02348; GroEL; 1. DR PROSITE; PS00296; CHAPERONINS_CPN60; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_00600}; KW Chaperone {ECO:0000256|HAMAP-Rule:MF_00600}; KW Complete proteome {ECO:0000313|Proteomes:UP000050321, KW ECO:0000313|Proteomes:UP000059440}; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00600}; KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00600}; KW Plasmid {ECO:0000313|EMBL:AGS56781.1}; KW Stress response {ECO:0000313|EMBL:AGS56781.1}. SQ SEQUENCE 546 AA; 57062 MW; 4E48091CE2FC367A CRC64; MAAKDIRFGE DARSKMVRGV NVLANAVKAT LGPKGRNVVL QKSYGAPTIT KDGVSVAKEI ELADAFENMG AQMVKEVASK TSDNAGDGTT TATVLAQAFI REGMKAVAAG MNPMDLKRGI DQAVKAAVGE LKSLSKPSST SKEIAQVGAI SANSDANIGD LIAQAMDKVG KEGVITVEEG SGLDNELDVV EGMQFDRGYL SPYFVNNQQS MSADLDDPFI LLYDKKISNV RDLLPVLEGV AKAGKPLLIV AEEVEGEALA TLVVNTIRGI VKVCAVKAPG FGDRRKAMLE DMAILTGGVV ISEEVGLSLE KATIKDLGRA KKIQVSKENT TIIDGAGEGA GIEARIKQIK AQIEETSSDY DREKLQERVA KLAGGVAVIK VGAATEVEMK EKKARVEDAL HATRAAVEEG IVPGGGVALI RAKAAIAGIK GVNEDQNHGI QIALRAMEAP LREIVTNAGD EPSVILNRVV EGSGAFGYNA ANGEFGDMIE FGILDPTKVT RTALQNAASI AGLMITTEAM VAEAPKKDEP AMPAGGGMGG MGGMDF //