ID S5TUE5_ENTCL Unreviewed; 546 AA. AC S5TUE5; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 11-NOV-2015, entry version 20. DE RecName: Full=60 kDa chaperonin {ECO:0000256|HAMAP-Rule:MF_00600, ECO:0000256|RuleBase:RU000419}; DE AltName: Full=GroEL protein {ECO:0000256|HAMAP-Rule:MF_00600}; DE AltName: Full=Protein Cpn60 {ECO:0000256|HAMAP-Rule:MF_00600}; GN Name=groEL {ECO:0000256|HAMAP-Rule:MF_00600, GN ECO:0000313|EMBL:AGS56781.1}; GN Synonyms=groL {ECO:0000256|HAMAP-Rule:MF_00600, GN ECO:0000313|EMBL:AHN60531.1}; GN ORFNames=pCRE727_16 {ECO:0000313|EMBL:AHN60531.1}, pNDM1_EC14653_00120 GN {ECO:0000313|EMBL:AKN19823.1}, pYQ13500_017 GN {ECO:0000313|EMBL:AKP49212.1}; OS Enterobacter cloacae. OG Plasmid pCR16-ECL-NDM-1 {ECO:0000313|EMBL:AKN35257.1}, OG Plasmid pECL3-NDM-1 {ECO:0000313|EMBL:AGS56781.1}, OG Plasmid pNDM-Ec1GN574 {ECO:0000313|EMBL:AIM48565.1}, OG Plasmid pNDM-HF727 {ECO:0000313|EMBL:AHN60531.1}, OG Plasmid pNDM1_EC14653 {ECO:0000313|EMBL:AKN19823.1}, and OG Plasmid pYQ13500-NDM {ECO:0000313|EMBL:AKP49212.1}. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex. OX NCBI_TaxID=550 {ECO:0000313|EMBL:AGS56781.1}; RN [1] {ECO:0000313|EMBL:AHN60531.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CRE727 {ECO:0000313|EMBL:AHN60531.1}; RC PLASMID=pNDM-HF727 {ECO:0000313|EMBL:AHN60531.1}; RA Ho P.L., Li Z., Lo W.U., Cheung Y.Y., Lin C.H., Sham P.C., RA Cheng V.C.C., Ng T.K., Que T.L., Chow K.H.; RT "Identification and characterization of a novel incompatibility group RT X3 plasmid carrying blaNDM-1 in Enterobacteriaceae isolates with RT epidemiological links to multiple geographical areas in China."; RL Emerg. Microbes Infect. 1:e39-e39(2012). RN [2] {ECO:0000313|EMBL:AGS56781.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ECL3 {ECO:0000313|EMBL:AGS56781.1}; RC PLASMID=pECL3-NDM-1 {ECO:0000313|EMBL:AGS56781.1}; RA Wailan A.M., Sidjabat H.E., Paterson D.L.; RT "The conjugation frequency and genetic surrounding of blaNDM-1, RT blaNDM-3 and blaNDM-6 carrying plasmids in Enterobacteriaceae."; RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:AHN60531.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CRE727 {ECO:0000313|EMBL:AHN60531.1}; RC PLASMID=pNDM-HF727 {ECO:0000313|EMBL:AHN60531.1}; RA Ho P.L., Lo W.U., Li Z., Chow K.H., Lin C.H., Chan W.; RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:AIM48565.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=GN574 {ECO:0000313|EMBL:AIM48565.1}; RC PLASMID=pNDM-Ec1GN574 {ECO:0000313|EMBL:AIM48565.1}; RX PubMed=25845877; DOI=10.1128/AAC.04862-14; RA Tijet N., Richardson D., MacMullin G., Patel S.N., Melano R.G.; RT "Characterization of multiple NDM-1-producing Enterobacteriaceae RT isolates from the same patient."; RL Antimicrob. Agents Chemother. 59:3648-3651(2015). RN [5] {ECO:0000313|EMBL:AKP49212.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=EC-YQ13500 {ECO:0000313|EMBL:AKP49212.1}; RC PLASMID=pYQ13500-NDM {ECO:0000313|EMBL:AKP49212.1}; RX PubMed=26047502; RA Yang Q., Fang L., Fu Y., Du X., Shen Y., Yu Y.; RT "Dissemination of NDM-1-Producing Enterobacteriaceae Mediated by the RT IncX3-Type Plasmid."; RL PLoS ONE 10:E0129454-E0129454(2015). RN [6] {ECO:0000313|EMBL:AKN35257.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CR16 {ECO:0000313|EMBL:AKN35257.1}; RC PLASMID=pCR16-ECL-NDM-1 {ECO:0000313|EMBL:AKN35257.1}; RA Wailan A.M., Paterson D.L., Kennedy K., Ingram P., Paterson D.L., RA Sidjabat H.E.; RT "Genomic characteristics of NDM-producing Enterobacteriaceae in RT Australia and their blaNDM genetic contexts."; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:AKN19823.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=WCHECl-14653 {ECO:0000313|EMBL:AKN19823.1}; RC PLASMID=pNDM1_EC14653 {ECO:0000313|EMBL:AKN19823.1}; RA Chooi Y.-H.; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Prevents misfolding and promotes the refolding and CC proper assembly of unfolded polypeptides generated under stress CC conditions. {ECO:0000256|HAMAP-Rule:MF_00600, CC ECO:0000256|RuleBase:RU000419}. CC -!- SUBUNIT: Oligomer of 14 subunits composed of two stacked rings of CC 7 subunits. {ECO:0000256|HAMAP-Rule:MF_00600, CC ECO:0000256|RuleBase:RU000419}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00600}. CC -!- SIMILARITY: Belongs to the chaperonin (HSP60) family. CC {ECO:0000256|HAMAP-Rule:MF_00600, ECO:0000256|RuleBase:RU000418}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KC887917; AGS56781.1; -; Genomic_DNA. DR EMBL; KF976405; AHN60531.1; -; Genomic_DNA. DR EMBL; KJ812998; AIM48565.1; -; Genomic_DNA. DR EMBL; KP868647; AKN19823.1; -; Genomic_DNA. DR EMBL; KP826704; AKN35257.1; -; Genomic_DNA. DR EMBL; KR059865; AKP49212.1; -; Genomic_DNA. DR RefSeq; WP_004201176.1; NZ_JZZK01000037.1. DR RefSeq; YP_009023656.1; NC_023914.1. DR GeneID; 18983793; -. DR KEGG; pg:18983793; -. DR KO; K04077; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP. DR GO; GO:0042026; P:protein refolding; IEA:UniProtKB-HAMAP. DR Gene3D; 1.10.560.10; -; 2. DR Gene3D; 3.50.7.10; -; 1. DR HAMAP; MF_00600; CH60; 1. DR InterPro; IPR018370; Chaperonin_Cpn60_CS. DR InterPro; IPR001844; Chaprnin_Cpn60. DR InterPro; IPR002423; Cpn60/TCP-1. DR InterPro; IPR027409; GroEL-like_apical_dom. DR InterPro; IPR027413; GROEL-like_equatorial. DR Pfam; PF00118; Cpn60_TCP1; 1. DR PRINTS; PR00298; CHAPERONIN60. DR SUPFAM; SSF52029; SSF52029; 1. DR TIGRFAMs; TIGR02348; GroEL; 1. DR PROSITE; PS00296; CHAPERONINS_CPN60; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_00600}; KW Chaperone {ECO:0000256|HAMAP-Rule:MF_00600}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00600}; KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00600}; KW Plasmid {ECO:0000313|EMBL:AGS56781.1}; KW Stress response {ECO:0000313|EMBL:AIM48565.1}. FT COILED 346 366 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 546 AA; 57062 MW; 4E48091CE2FC367A CRC64; MAAKDIRFGE DARSKMVRGV NVLANAVKAT LGPKGRNVVL QKSYGAPTIT KDGVSVAKEI ELADAFENMG AQMVKEVASK TSDNAGDGTT TATVLAQAFI REGMKAVAAG MNPMDLKRGI DQAVKAAVGE LKSLSKPSST SKEIAQVGAI SANSDANIGD LIAQAMDKVG KEGVITVEEG SGLDNELDVV EGMQFDRGYL SPYFVNNQQS MSADLDDPFI LLYDKKISNV RDLLPVLEGV AKAGKPLLIV AEEVEGEALA TLVVNTIRGI VKVCAVKAPG FGDRRKAMLE DMAILTGGVV ISEEVGLSLE KATIKDLGRA KKIQVSKENT TIIDGAGEGA GIEARIKQIK AQIEETSSDY DREKLQERVA KLAGGVAVIK VGAATEVEMK EKKARVEDAL HATRAAVEEG IVPGGGVALI RAKAAIAGIK GVNEDQNHGI QIALRAMEAP LREIVTNAGD EPSVILNRVV EGSGAFGYNA ANGEFGDMIE FGILDPTKVT RTALQNAASI AGLMITTEAM VAEAPKKDEP AMPAGGGMGG MGGMDF //