ID S5G996_9CALI Unreviewed; 267 AA. AC S5G996; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 03-JUL-2019, entry version 20. DE SubName: Full=RNA dependend RNA polymerase {ECO:0000313|EMBL:AGQ57030.1}; DE Flags: Fragment; OS Norovirus Hu/GII/Oranienburg1190/2012/DE. OC Viruses; Riboviria; Caliciviridae; Norovirus. OX NCBI_TaxID=1357776 {ECO:0000313|EMBL:AGQ57030.1}; RN [1] {ECO:0000313|EMBL:AGQ57030.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Hu/GII/Oranienburg1190/2012/DE {ECO:0000313|EMBL:AGQ57030.1}; RA Hoehne M., Niendorf S.; RT "Detection of recombinant norovirus in a large-scale gastroenteritis RT outbreak in Germany."; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:11128, Rhea:RHEA- CC COMP:11129, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, CC ChEBI:CHEBI:83400; EC=2.7.7.48; CC Evidence={ECO:0000256|SAAS:SAAS01199804}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KC832471; AGQ57030.1; -; Genomic_RNA. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0004386; F:helicase activity; IEA:InterPro. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro. DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro. DR InterPro; IPR004004; Helic/Pol/Pept_Calicivir-typ. DR InterPro; IPR001205; RNA-dir_pol_C. DR InterPro; IPR007094; RNA-dir_pol_PSvirus. DR Pfam; PF00680; RdRP_1; 1. DR PRINTS; PR00918; CALICVIRUSNS. DR PROSITE; PS50507; RDRP_SSRNA_POS; 1. PE 4: Predicted; KW Nucleotidyltransferase {ECO:0000256|SAAS:SAAS01199808}; KW RNA-directed RNA polymerase {ECO:0000256|SAAS:SAAS01199760}; KW Transferase {ECO:0000256|SAAS:SAAS01199803}; KW Viral RNA replication {ECO:0000256|SAAS:SAAS01199810}. FT DOMAIN 1 114 RdRp catalytic. {ECO:0000259|PROSITE: FT PS50507}. FT NON_TER 1 1 {ECO:0000313|EMBL:AGQ57030.1}. SQ SEQUENCE 267 AA; 30060 MW; 9215B43E32A8BF9D CRC64; SRWDSTQQRA VLAAALEIMV RFSAEPQLAQ IVAEDLLAPS VVDVGDFKIS INEGLPSGVP CTSQWNSIAH WLLTLCALSE VTKLSPDIVQ ANSMFSFYGD DEIVSTDIKL DPEKLTTKLK EYGLKPTRPD KTEGPLIISE DLNGLTFLRR TVTRDPAGWF GKLDQSSILR QMYWTRGPNH EDPNETMIPH SQRPIQLMAL LGEASLHGPS FYSKISKLVI TELKEGGMDF YVPRQEPMFR WMRFSDLSTW EGDRNLAPNF VNEDGVE //