ID S4VID8_MYCTX Unreviewed; 100 AA. AC S4VID8; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 27-NOV-2024, entry version 29. DE SubName: Full=Gyrase subunit A {ECO:0000313|EMBL:AGO65320.1}; DE Flags: Fragment; GN Name=gyrA {ECO:0000313|EMBL:AGO65320.1}; OS Mycobacterium tuberculosis. OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae; OC Mycobacterium; Mycobacterium tuberculosis complex. OX NCBI_TaxID=1773 {ECO:0000313|EMBL:AGO65320.1}; RN [1] {ECO:0000313|EMBL:AGO65320.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=GA_1495 {ECO:0000313|EMBL:AGO65320.1}; RA Singh P., Jain A., Dixit P., Jaiswal I., Prakash S., Singh U., Singh D.D.; RT "Mutations in gyrA gene of fluoroquinolone resistant Mycobacterium RT tuberculosis clinical isolates from a North Indian hospital."; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP-dependent breakage, passage and rejoining of double- CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185}; CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit CC family. {ECO:0000256|ARBA:ARBA00008263}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KC777356; AGO65320.1; -; Genomic_DNA. DR AlphaFoldDB; S4VID8; -. DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter. DR GO; GO:0009330; C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex; IEA:TreeGrafter. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt. DR GO; GO:0006265; P:DNA topological change; IEA:InterPro. DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1. DR InterPro; IPR013760; Topo_IIA-like_dom_sf. DR InterPro; IPR013758; Topo_IIA_A/C_ab. DR InterPro; IPR002205; Topo_IIA_dom_A. DR InterPro; IPR050220; Type_II_DNA_Topoisomerases. DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1. DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1. DR Pfam; PF00521; DNA_topoisoIV; 1. DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1. PE 3: Inferred from homology; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Isomerase {ECO:0000256|ARBA:ARBA00023235}; KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}. FT DOMAIN 13..100 FT /note="DNA topoisomerase type IIA" FT /evidence="ECO:0000259|Pfam:PF00521" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AGO65320.1" FT NON_TER 100 FT /evidence="ECO:0000313|EMBL:AGO65320.1" SQ SEQUENCE 100 AA; 11061 MW; 1E69BC3632BFB339 CRC64; SYIDYAMSVI VGRALPEVRD GLKPVHRRVL YAMFDSGFRP DRSHAKSARS VAETMGNYHP HGDVSIYDTL VRMAQPWSLR YPLVDGQGNF GSPGNDPPAA //