ID   S4VID8_MYCTX            Unreviewed;       100 AA.
AC   S4VID8;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-NOV-2024, entry version 29.
DE   SubName: Full=Gyrase subunit A {ECO:0000313|EMBL:AGO65320.1};
DE   Flags: Fragment;
GN   Name=gyrA {ECO:0000313|EMBL:AGO65320.1};
OS   Mycobacterium tuberculosis.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=1773 {ECO:0000313|EMBL:AGO65320.1};
RN   [1] {ECO:0000313|EMBL:AGO65320.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=GA_1495 {ECO:0000313|EMBL:AGO65320.1};
RA   Singh P., Jain A., Dixit P., Jaiswal I., Prakash S., Singh U., Singh D.D.;
RT   "Mutations in gyrA gene of fluoroquinolone resistant Mycobacterium
RT   tuberculosis clinical isolates from a North Indian hospital.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
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DR   EMBL; KC777356; AGO65320.1; -; Genomic_DNA.
DR   AlphaFoldDB; S4VID8; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0009330; C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex; IEA:TreeGrafter.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   InterPro; IPR050220; Type_II_DNA_Topoisomerases.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          13..100
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|Pfam:PF00521"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AGO65320.1"
FT   NON_TER         100
FT                   /evidence="ECO:0000313|EMBL:AGO65320.1"
SQ   SEQUENCE   100 AA;  11061 MW;  1E69BC3632BFB339 CRC64;
     SYIDYAMSVI VGRALPEVRD GLKPVHRRVL YAMFDSGFRP DRSHAKSARS VAETMGNYHP
     HGDVSIYDTL VRMAQPWSLR YPLVDGQGNF GSPGNDPPAA
//