ID S4UVH2_9CALI Unreviewed; 527 AA. AC S4UVH2; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 27-NOV-2024, entry version 40. DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107}; DE Flags: Fragment; OS Norovirus Hu/GII/Seoul1388/KOR/2010. OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; OC Picornavirales; Caliciviridae; Norovirus; Norwalk virus. OX NCBI_TaxID=1336107 {ECO:0000313|EMBL:AGM46373.1}; RN [1] {ECO:0000313|EMBL:AGM46373.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Hu/GII/Seoul1388/KOR/2010 {ECO:0000313|EMBL:AGM46373.1}; RA Han T.H., Lam T.T.Y., Pybus O.G., Park S.H., Chung J.Y.; RT "The recombinant origin of emerging humannorovirus GII.4/2008."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- CC diphosphate + phosphate + H(+); Xref=Rhea:RHEA:23680, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; EC=3.6.1.15; CC Evidence={ECO:0000256|ARBA:ARBA00001491}; CC -!- SUBCELLULAR LOCATION: Host cell {ECO:0000256|ARBA:ARBA00004340}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00870}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JX439825; AGM46373.1; -; Genomic_RNA. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0004386; F:helicase activity; IEA:InterPro. DR GO; GO:0017111; F:ribonucleoside triphosphate phosphatase activity; IEA:UniProtKB-EC. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro. DR GO; GO:0006508; P:proteolysis; IEA:InterPro. DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro. DR CDD; cd23192; Caliciviridae_RdRp; 1. DR Gene3D; 1.20.960.20; -; 1. DR Gene3D; 3.30.70.270; -; 2. DR Gene3D; 6.10.250.3230; -; 1. DR InterPro; IPR043502; DNA/RNA_pol_sf. DR InterPro; IPR004004; Helic/Pol/Pept_Calicivir-typ. DR InterPro; IPR001665; Norovirus_pept_C37. DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase. DR InterPro; IPR001205; RNA-dir_pol_C. DR InterPro; IPR007094; RNA-dir_pol_PSvirus. DR Pfam; PF00680; RdRP_1; 1. DR PRINTS; PR00918; CALICVIRUSNS. DR SUPFAM; SSF56672; DNA/RNA polymerases; 1. DR PROSITE; PS51537; NV_3CL_PRO; 1. DR PROSITE; PS50507; RDRP_SSRNA_POS; 1. PE 4: Predicted; KW Covalent protein-RNA linkage {ECO:0000256|ARBA:ARBA00022520}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022807}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW Protease {ECO:0000256|ARBA:ARBA00022807}; KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484}; KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}. FT DOMAIN 1..17 FT /note="Peptidase C37" FT /evidence="ECO:0000259|PROSITE:PS51537" FT DOMAIN 253..374 FT /note="RdRp catalytic" FT /evidence="ECO:0000259|PROSITE:PS50507" FT REGION 1..20 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AGM46373.1" SQ SEQUENCE 527 AA; 58347 MW; ACB276B1FDF264E0 CRC64; NTVICATQGS EGEATLEGGD NKGTYCGAPI LGPGSAPKLS TKTKFWRSST APLPPGTYEP AYLGGKDPRV KGGPSLQQVM RDQLKPFTEP RGKPPKPSVL EAAKKTIINV LEQTIDPPEK WSFAQACASL DKTTSSGHPH HMRKNDCWNG ESFTGKLADQ ASKANLMFEE GKNMTPVYTA ALKDELVKTD KIYGKIKKRL LWGSDLATMI RCARAFGGLM DELKAHCVTL PIRVGMNMNE DGPIIFERHS RYTYHYDADY SRWDSTQQRA VLAAALEIMV KFSPEPHLAQ VVAEDLLSPS VVDVGDFTIS INEGLPSGVP CTSQWNSIAH WLLTLCALSE VTNLSPDTIQ ANSLFSFYGD DEIVSTDIKL DPEKLTAKLR EYGLKPTRPD KTEGPLAISE DLNGLTFLRR TVTRDPAGWF GKLEQSSILR QMYWTRGSNH EDPSETMIPH SQRPIQLMSL LGEAALHGPA FYSKISKLVI AELKEGGMDF YVPRQEPMFR WMRFSDLSTW EGGRNLAPSF VNEDGVE //