ID S4UTK9_9CALI Unreviewed; 527 AA. AC S4UTK9; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 08-NOV-2023, entry version 37. DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107}; DE Flags: Fragment; OS Norovirus Hu/GII/Seoul1400/KOR/2010. OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; OC Picornavirales; Caliciviridae; Norovirus; Norwalk virus. OX NCBI_TaxID=1336110 {ECO:0000313|EMBL:AGM46376.1}; RN [1] {ECO:0000313|EMBL:AGM46376.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Hu/GII/Seoul1400/KOR/2010 {ECO:0000313|EMBL:AGM46376.1}; RA Han T.H., Lam T.T.Y., Pybus O.G., Park S.H., Chung J.Y.; RT "The recombinant origin of emerging humannorovirus GII.4/2008."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Viral genome-linked protein is covalently linked to the 5'- CC end of the positive-strand, negative-strand genomic RNAs and subgenomic CC RNA. Acts as a genome-linked replication primer. May recruit ribosome CC to viral RNA thereby promoting viral proteins translation. CC {ECO:0000256|ARBA:ARBA00025359}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00870}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JX439826; AGM46376.1; -; Genomic_RNA. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0004386; F:helicase activity; IEA:InterPro. DR GO; GO:0017111; F:ribonucleoside triphosphate phosphatase activity; IEA:UniProtKB-EC. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro. DR GO; GO:0006508; P:proteolysis; IEA:InterPro. DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro. DR CDD; cd23192; Caliciviridae_RdRp; 1. DR Gene3D; 1.20.960.20; -; 1. DR Gene3D; 3.30.70.270; -; 2. DR Gene3D; 6.10.250.3230; -; 1. DR InterPro; IPR043502; DNA/RNA_pol_sf. DR InterPro; IPR004004; Helic/Pol/Pept_Calicivir-typ. DR InterPro; IPR001665; Norovirus_pept_C37. DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase. DR InterPro; IPR001205; RNA-dir_pol_C. DR InterPro; IPR007094; RNA-dir_pol_PSvirus. DR Pfam; PF00680; RdRP_1; 1. DR PRINTS; PR00918; CALICVIRUSNS. DR SUPFAM; SSF56672; DNA/RNA polymerases; 1. DR PROSITE; PS51537; NV_3CL_PRO; 1. DR PROSITE; PS50507; RDRP_SSRNA_POS; 1. PE 4: Predicted; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}. FT DOMAIN 1..17 FT /note="Peptidase C37" FT /evidence="ECO:0000259|PROSITE:PS51537" FT DOMAIN 253..374 FT /note="RdRp catalytic" FT /evidence="ECO:0000259|PROSITE:PS50507" FT REGION 1..20 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AGM46376.1" SQ SEQUENCE 527 AA; 58361 MW; ACB276B1FDF2637E CRC64; NTVICATQGS EGEATLEGGD NKGTYCGAPI LGPGSAPKLS TKTKFWRSST APLPPGTYEP AYLGGKDPRV KGGPSLQQVM RDQLKPFTEP RGKPPKPSVL EAAKKTIINV LEQTIDPPEK WSFAQACASL DKTTSSGHPH HMRKNDCWNG ESFTGKLADQ ASKANLMFEE GKNMTPVYTA ALKDELVKTD KIYGKIKKRL LWGSDLATMI RCARAFGGLM DELKAHCVTL PIRVGMNMNE DGPIIFERHS RYTYHYDADY SRWDSTQQRA VLAAALEIMV KFSPEPHLAQ VVAEDLLSPS VVDVGDFTIS INEGLPSGVP CTSQWNSIAH WLLTLCALSE VTNLSPDTIQ ANSLFSFYGD DEIVSTDIKL DPEKLTAKLR EYGLKPTRPD KTEGPLAISE DLNGLTFLRR TVTRDPAGWF GKLEQSSILR QMYWTRGSNH EDPSETMIPH SQRPIQLMSL LGEAALHGPA FYSKISKLVI AELKEGGMDF YVPRQEPMFR WMRFSDLSTW EGARNLAPSF VNEDGVE //