ID S4T9C1_SALVM Unreviewed; 152 AA. AC S4T9C1; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-MAY-2022, entry version 18. DE RecName: Full=Phenylalanine ammonia-lyase {ECO:0000256|ARBA:ARBA00012139}; DE EC=4.3.1.24 {ECO:0000256|ARBA:ARBA00012139}; DE Flags: Fragment; OS Salix viminalis (Common osier) (Basket willow). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC rosids; fabids; Malpighiales; Salicaceae; Saliceae; Salix. OX NCBI_TaxID=40686 {ECO:0000313|EMBL:AFV91501.1}; RN [1] {ECO:0000313|EMBL:AFV91501.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=23924375; DOI=10.1186/1754-6834-6-114; RA Perdereau A.C., Douglas G.C., Hodkinson T.R., Kelleher C.T.; RT "High levels of variation in Salix lignocellulose genes revealed using RT poplar genomic resources."; RL Biotechnol. Biofuels 6:114-114(2013). CC -!- FUNCTION: This is a key enzyme of plant metabolism catalyzing the first CC reaction in the biosynthesis from L-phenylalanine of a wide variety of CC natural products based on the phenylpropane skeleton. CC {ECO:0000256|ARBA:ARBA00002235}. CC -!- CATALYTIC ACTIVITY: CC Reaction=L-phenylalanine = (E)-cinnamate + NH4(+); CC Xref=Rhea:RHEA:21384, ChEBI:CHEBI:15669, ChEBI:CHEBI:28938, CC ChEBI:CHEBI:58095; EC=4.3.1.24; CC Evidence={ECO:0000256|ARBA:ARBA00023537}; CC -!- PATHWAY: Phenylpropanoid metabolism; trans-cinnamate biosynthesis; CC trans-cinnamate from L-phenylalanine: step 1/1. CC {ECO:0000256|ARBA:ARBA00005138}. CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC -!- SIMILARITY: Belongs to the PAL/histidase family. CC {ECO:0000256|ARBA:ARBA00007238}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JQ345659; AFV91501.1; -; Genomic_DNA. DR UniPathway; UPA00713; UER00725. DR GO; GO:0045548; F:phenylalanine ammonia-lyase activity; IEA:UniProtKB-EC. DR GO; GO:0009800; P:cinnamic acid biosynthetic process; IEA:UniProtKB-UniPathway. DR Gene3D; 1.10.274.20; -; 1. DR InterPro; IPR001106; Aromatic_Lyase. DR InterPro; IPR008948; L-Aspartase-like. DR InterPro; IPR023144; Phe_NH3-lyase_shielding_dom_sf. DR PANTHER; PTHR10362; PTHR10362; 1. DR Pfam; PF00221; Lyase_aromatic; 1. DR SUPFAM; SSF48557; SSF48557; 1. PE 3: Inferred from homology; KW Lyase {ECO:0000313|EMBL:AFV91501.1}; KW Phenylalanine catabolism {ECO:0000256|ARBA:ARBA00023232}; KW Phenylpropanoid metabolism {ECO:0000256|ARBA:ARBA00023051}. FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AFV91501.1" FT NON_TER 152 FT /evidence="ECO:0000313|EMBL:AFV91501.1" SQ SEQUENCE 152 AA; 16507 MW; 04CB6600DBAF4C3E CRC64; GNFQGTPIGV SMDNVRLAIA SIGKLLFAQF SELVNDFYNN GLPSNLTASR NPSLDYGFKG AEIAMASYCS ELQYLANPVT SHVQSAEQHN QDVNSLGLIS SRKTAEAVDI LKLMSTTFLV ALCQAVDLRH LEENLRSAVK NTVSQVSKRV LT //