ID S4S378_9RODE Unreviewed; 609 AA. AC S4S378; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 27-NOV-2024, entry version 30. DE SubName: Full=BRCA1 {ECO:0000313|EMBL:AEI70634.1}; DE Flags: Fragment; OS Gerbilliscus kempi (Northern savanna gerbil). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Gerbillinae; Gerbilliscus. OX NCBI_TaxID=410301 {ECO:0000313|EMBL:AEI70634.1}; RN [1] {ECO:0000313|EMBL:AEI70634.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ABC-14 {ECO:0000313|EMBL:AEI70634.1}; RA Granjon L., Colangelo P., Tatard C., Colyn M., Dobigny G., Nicolas V.; RT "Intrageneric relationships within Gerbilliscus (Rodentia, Muridae, RT Gerbillinae), with characterization of an additional West African RT species."; RL Zootaxa 3325:1-25(2012). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JF716036; AEI70634.1; -; Genomic_DNA. DR GO; GO:0070531; C:BRCA1-A complex; IEA:TreeGrafter. DR GO; GO:0031436; C:BRCA1-BARD1 complex; IEA:TreeGrafter. DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter. DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:TreeGrafter. DR GO; GO:0043009; P:chordate embryonic development; IEA:TreeGrafter. DR GO; GO:0009048; P:dosage compensation by inactivation of X chromosome; IEA:TreeGrafter. DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:TreeGrafter. DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:TreeGrafter. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:TreeGrafter. DR InterPro; IPR031099; BRCA1-associated. DR InterPro; IPR025994; BRCA1_serine_dom. DR PANTHER; PTHR13763:SF0; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN; 1. DR PANTHER; PTHR13763; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1; 1. DR Pfam; PF12820; BRCT_assoc; 1. DR PIRSF; PIRSF001734; BRCA1; 1. PE 4: Predicted; KW DNA damage {ECO:0000256|ARBA:ARBA00022763}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}. FT DOMAIN 9..170 FT /note="BRCA1 serine-rich" FT /evidence="ECO:0000259|Pfam:PF12820" FT REGION 193..231 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 283..429 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 193..219 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 294..323 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 325..357 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 363..377 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AEI70634.1" FT NON_TER 609 FT /evidence="ECO:0000313|EMBL:AEI70634.1" SQ SEQUENCE 609 AA; 67206 MW; 9404B05F7C7B6B79 CRC64; EKKVDSNADS LCGRKKCNNQ KSLCLEDSGA AQNVPWITLN SXIRKVNEWF SRTGEMLTSD SASDKRQASN AEAAVALEVS NEVDGCIGNS KKIDLVTSDP HHALMGKSEK DFSQPVKNNI XDKIFGKTYX RKGSFLHLNH VTEIISTFTA EPQMTQEQPF TNKLKRKRRS TCLYPEDFIK KADLTIVQKT PENINQGTDQ MEPNDQMMGI TSNGQENETK SNDLQKEKTA NPVESLGKES AFTAKARPMS NSISDLEVEL NVHNSKAPKK NRLRRKASTI SDCALEPVSR DPSSPTHAEL QIDSYSSSEE TKKNNSNQTL VKHIRKPQLI EDPEPAPDAK KKEPNEQMRK RTASDAFPEE KLTNIDGSSS SEPEGPVSPS PQKREIEKLX SSKMPDNTKE LTDLVLGGER CLSTERSEES TSVSLVPDTD YDTQNSVSVL EANTVRSAKT GSIKCLTQFV AXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXIPETTEME XSDLDXQYLQ NTFQVSKRQS FALFSKPRSS LNECATVSTH SLPLREXXPK VTSEGKKNQG HEESEISHVP AVTAAMDLPV LPQQGKPGAN TLCAGVCGRG XSSQYRSSE //