ID S3KS27_TREDN Unreviewed; 259 AA. AC S3KS27; DT 18-SEP-2013, integrated into UniProtKB/TrEMBL. DT 18-SEP-2013, sequence version 1. DT 01-OCT-2014, entry version 8. DE RecName: Full=Putative GTP cyclohydrolase 1 type 2 {ECO:0000256|RuleBase:RU004385}; DE EC=3.5.4.16 {ECO:0000256|RuleBase:RU004385}; DE AltName: Full=GTP cyclohydrolase I {ECO:0000256|RuleBase:RU004385}; GN ORFNames=HMPREF9731_01016 {ECO:0000313|EMBL:EPF39956.1}; OS Treponema denticola SP23. OC Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Treponema. OX NCBI_TaxID=999435 {ECO:0000313|EMBL:EPF39956.1}; RN [1] {ECO:0000313|EMBL:EPF39956.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=SP23 {ECO:0000313|EMBL:EPF39956.1}; RG The Broad Institute Genomics Platform; RA Earl A., Ward D., Feldgarden M., Gevers D., Blanton J.M., Fenno C.J., RA Baranova O.V., Mathney J., Dewhirst F.E., Izard J., Walker B., RA Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., RA Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., RA Murphy C., Pearson M., Poon T.W., Priest M., Roberts A., Saif S., RA Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.; RT "The Genome Sequence of Treponema denticola SP23/ F0463."; RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Converts GTP to dihydroneopterin triphosphate. CC {ECO:0000256|RuleBase:RU004385}. CC -!- CATALYTIC ACTIVITY: GTP + H(2)O = formate + 2-amino-4-hydroxy-6- CC (erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. CC {ECO:0000256|RuleBase:RU004385}. CC -!- PATHWAY: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate CC biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step CC 1/1. {ECO:0000256|RuleBase:RU004385}. CC -!- SIMILARITY: Belongs to the GTP cyclohydrolase I type 2 family. CC {ECO:0000256|RuleBase:RU004385}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:EPF39956.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AHAB01000004; EPF39956.1; -; Genomic_DNA. DR EnsemblBacteria; EPF39956; EPF39956; HMPREF9731_01016. DR UniPathway; UPA00848; UER00151. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW. DR GO; GO:0003934; F:GTP cyclohydrolase I activity; IEA:UniProtKB-EC. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0035998; P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process; IEA:UniProtKB-UniPathway. DR InterPro; IPR002678; GTP_cyclohydrolase_I/Nif3. DR PANTHER; PTHR13799; PTHR13799; 1. DR Pfam; PF01784; NIF3; 1. DR SUPFAM; SSF102705; SSF102705; 1. DR TIGRFAMs; TIGR00486; YbgI_SA1388; 1. PE 3: Inferred from homology; KW GTP-binding {ECO:0000256|RuleBase:RU004385}; KW Hydrolase {ECO:0000256|RuleBase:RU004385}; KW Metal-binding {ECO:0000256|RuleBase:RU004385}; KW Nucleotide-binding {ECO:0000256|RuleBase:RU004385}. SQ SEQUENCE 259 AA; 28773 MW; EF26542F6FF305C8 CRC64; MKLKELDLYF TELLNIDAFA AQDLSQNGVQ VQNSGKEIKK VAFAVDACLQ SIKEAAERKA DMLFVHHGLF WSRSLRIMGN HYHRIKALLD NDIVLYAVHL PLDAHPLYGN NIGLARRLEL ENLKEFGMYR GLNIGFYGSL PLKEGSEEGL ELDEIINKLF PQGEKPANIL PFGPKKVKTI GIISGGAASE IDDAIALGLD LYITGEIEHI TYHNALENRI NVIAGGHYQT ETVGVQLVAK KLELDTNLET CFIDIPTGF //