ID R5ZIT3_9STRE Unreviewed; 483 AA. AC R5ZIT3; DT 24-JUL-2013, integrated into UniProtKB/TrEMBL. DT 24-JUL-2013, sequence version 1. DT 03-MAY-2023, entry version 30. DE SubName: Full=Di-/tripeptide transporter {ECO:0000313|EMBL:CDA38745.1}; GN ORFNames=BN551_00572 {ECO:0000313|EMBL:CDA38745.1}; OS Streptococcus thermophilus CAG:236. OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae; OC Streptococcus; environmental samples. OX NCBI_TaxID=1263110 {ECO:0000313|EMBL:CDA38745.1, ECO:0000313|Proteomes:UP000017969}; RN [1] {ECO:0000313|EMBL:CDA38745.1, ECO:0000313|Proteomes:UP000017969} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MGS:236 {ECO:0000313|Proteomes:UP000017969}; RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S., RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T., RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N., RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T., RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R., RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N., RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W., RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P., RA Wang J., Brunak S., Ehrlich S.D.; RT "Dependencies among metagenomic species, viruses, plasmids and units of RT genetic variation."; RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003755}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141, CC ECO:0000256|RuleBase:RU003755}. CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton- CC dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. CC {ECO:0000256|ARBA:ARBA00005982, ECO:0000256|RuleBase:RU003755}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:CDA38745.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CBBT010000042; CDA38745.1; -; Genomic_DNA. DR AlphaFoldDB; R5ZIT3; -. DR EnsemblBacteria; CDA38745; CDA38745; BN551_00572. DR Proteomes; UP000017969; Unassembled WGS sequence. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:1904680; F:peptide transmembrane transporter activity; IEA:InterPro. DR GO; GO:0006857; P:oligopeptide transport; IEA:InterPro. DR CDD; cd17346; MFS_DtpA_like; 1. DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1. DR InterPro; IPR005279; Dipep/tripep_permease. DR InterPro; IPR020846; MFS_dom. DR InterPro; IPR036259; MFS_trans_sf. DR InterPro; IPR000109; POT_fam. DR InterPro; IPR018456; PTR2_symporter_CS. DR PANTHER; PTHR23517:SF15; PROTON-DEPENDENT OLIGOPEPTIDE FAMILY TRANSPORT PROTEIN-RELATED; 1. DR PANTHER; PTHR23517; RESISTANCE PROTEIN MDTM, PUTATIVE-RELATED-RELATED; 1. DR Pfam; PF00854; PTR2; 1. DR SUPFAM; SSF103473; MFS general substrate transporter; 1. DR TIGRFAMs; TIGR00924; yjdL_sub1_fam; 1. DR PROSITE; PS50850; MFS; 1. DR PROSITE; PS01022; PTR2_1; 1. DR PROSITE; PS01023; PTR2_2; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU003755}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003755}. FT TRANSMEM 27..44 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 56..77 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 84..102 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 108..125 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 146..169 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 175..196 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 220..242 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 248..270 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 282..298 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 327..346 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 358..378 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 390..412 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 424..445 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 451..471 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 1..201 FT /note="Major facilitator superfamily (MFS) profile" FT /evidence="ECO:0000259|PROSITE:PS50850" SQ SEQUENCE 483 AA; 52776 MW; 27FF1B0826802247 CRC64; MEDKGKTFFG QPLGLLTLFM TEMWERFSYY GMRAILLYYM WFLISTGDLH ITRATAASIM AIYASMVYLS GTIGGFVADR IIGARPAVFW GGVLIMLGHI VLSLPFGASA LFGSIILIII GTGFLKPNVS TLVGTLYDEH DRRRDAGFSI FVFGINLGAF IAPLIVGAAQ EAAGYHVAFS LAAIGMFIGL LVYYFGGKKT LDPHYLRPTD PLAPEEVKPL LVKVSLAVAG FIAIIVVMNL VGWNSLPAYI NLLTIVAIAI PVFYFVWMIA SVKVTATERL RVVSYIPLFI AAVLFWAIEE QGSVVLATFA AERVDSSWFP VSWFQSLNPL FIMLYTPFFA WLWTAWKKNQ PSSPTKFAVG LMFAGLSFLL MAIPGALYGT SGKVSPLWLV GSWALVIVGE MLISPVGLSV TTKLAPKAFN SQMMSMWFLS SAVGSALNAQ LVTLYNAKSE VAYFSYFGLG SVVLGIVLVF LSKRIQGLMQ GVE //