ID R4ZHW8_DANPL Unreviewed; 788 AA. AC R4ZHW8; DT 24-JUL-2013, integrated into UniProtKB/TrEMBL. DT 24-JUL-2013, sequence version 1. DT 11-DEC-2013, entry version 4. DE SubName: Full=Na+/K+ ATPase alpha subunit; DE Flags: Fragment; GN Name=K+ ATPase alpha subunit; Synonyms=Na+; OS Danaus plexippus (Monarch butterfly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; OC Papilionoidea; Nymphalidae; Danainae; Danaini; Danaina; Danaus; OC Danaus. OX NCBI_TaxID=13037; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Central nervous system; RX PubMed=24033181; DOI=10.1111/evo.12152; RA Petschenka G., Fandrich S., Sander N., Wagschal V., Boppre M., RA Dobler S.; RT "Stepwise evolution of resistance to toxic cardenolides via genetic RT substitutions in the na(+) /k(+) -ATPase of milkweed butterflies RT (lepidoptera: danaini)."; RL Evolution 67:2753-2761(2013). CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HF945454; CCW28388.1; -; mRNA. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0019829; F:cation-transporting ATPase activity; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:InterPro. DR GO; GO:0015077; F:monovalent inorganic cation transmembrane transporter activity; IEA:InterPro. DR GO; GO:0006754; P:ATP biosynthetic process; IEA:InterPro. DR Gene3D; 1.20.1110.10; -; 2. DR Gene3D; 3.40.1110.10; -; 1. DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C. DR InterPro; IPR023299; ATPase_P-typ_cyto_domN. DR InterPro; IPR005775; ATPase_P-typ_Na/K_IIC. DR InterPro; IPR018303; ATPase_P-typ_P_site. DR InterPro; IPR023298; ATPase_P-typ_TM_dom. DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A. DR InterPro; IPR001757; Cation_transp_P_typ_ATPase. DR InterPro; IPR023214; HAD-like_dom. DR Pfam; PF00689; Cation_ATPase_C; 1. DR Pfam; PF00122; E1-E2_ATPase; 1. DR Pfam; PF00702; Hydrolase; 1. DR PRINTS; PR00119; CATATPASE. DR SUPFAM; SSF56784; SSF56784; 3. DR SUPFAM; SSF81660; SSF81660; 1. DR TIGRFAMs; TIGR01106; ATPase-IIC_X-K; 1. DR TIGRFAMs; TIGR01494; ATPase_P-type; 2. DR PROSITE; PS00154; ATPASE_E1_E2; 1. PE 2: Evidence at transcript level; KW ATP-binding; Hydrolase; Membrane; Nucleotide-binding; Transmembrane; KW Transmembrane helix. FT NON_TER 1 1 FT NON_TER 788 788 SQ SEQUENCE 788 AA; 85492 MW; 0A13E6B829FA4511 CRC64; LLLWIGAILC FIAYGIVAST VEEPSDDHLY LGIVLAAVVI VTGIFSYYQE SKSSKIMESF KNMVPQFATV IREGEKLTLR AEDLVLGDVV EVKFGDRIPA DIRIIEARGF KVDNSSLTGE SEPQSRGPEF TNENPLETKN LAFFSTNAVE GTAKGIVICC GDNTVMGRIA GLASGLDTGE TPIAKEIHHF IHLITGVAVF LGVTFFIIAF ILGYHWLDAV IFLIGIIVAN VPEGLLATVT VCLTLTAKRM ASKNCLVKNL EAVETLGSTS TICSDKTGTL TQNRMTVAHM WFDNQIIEAD TTEDQSGVQY DRTSPGFKAL AKIASLCNRA EFKGGQDGVP ILKKEVAGDA SEAALLKCME LALGDVLSIR KRNKKVCEIP FNSTNKYQVS IHESDDPSDP RHLLVMKGAP ERILERCSTI FIGGKEKVLD EEMKEAFNNA YLELGGLGER VLGFCDLQLP SDKYPIGYKF NTDDPNFPLD NLRFVGLMSM IDPPRAAVPD AVAKCRSAGI KVIMVTGDHP ITAKAIAKSV GIISEGNETV EDIAARLNIP VSEVNPREAK AAVVHGTELR DLNSDQLDEI LKFHTEIVFA RTSPQQKLII VEGCQRLGAI VAVTGDGVND SPALKKADIG VAMGIAGSDV SKQAADMILL DDNFASIVTG VEEGRLIFDN LKKSIAYTLT SNIPEISPFL AFILCDIPLP LGTVTILCID LGTDMVPAIA LAYEEAEADI MKRPPRNPFN DKLVNERLIS MAYGQIGMIQ AAAGFFVYFV IMAENGFLPT KLFGIRKQ //