ID MNHA1_STAAU Reviewed; 801 AA. AC Q9ZNG6; Q0Q2K7; DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 1. DT 03-MAR-2009, entry version 43. DE RecName: Full=Na(+)/H(+) antiporter subunit A1; DE AltName: Full=Mnh complex subunit A1; DE AltName: Full=Mrp complex subunit A1; GN Name=mnhA1; Synonyms=mrpA1; OS Staphylococcus aureus. OC Bacteria; Firmicutes; Bacillales; Staphylococcus. OX NCBI_TaxID=1280; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION OF ANTIPORTER RP ACTIVITY. RC STRAIN=ATCC 21027 / 209-P; RX MEDLINE=99069340; PubMed=9852009; RA Hiramatsu T., Kodama K., Kuroda T., Mizushima T., Tsuchiya T.; RT "A putative multisubunit Na+/H+ antiporter from Staphylococcus RT aureus."; RL J. Bacteriol. 180:6642-6648(1998). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-801, CHARACTERIZATION, AND RP PROBABLE ELECTROGENIC ANTIPORTER ACTIVITY. RC STRAIN=RF4220; RX PubMed=17293423; DOI=10.1128/JB.00021-07; RA Swartz T.H., Ito M., Ohira T., Natsui S., Hicks D.B., Krulwich T.A.; RT "Catalytic properties of Staphylococcus aureus and Bacillus members of RT the secondary cation/proton antiporter-3 (Mrp) family are revealed by RT an optimized assay in an Escherichia coli host."; RL J. Bacteriol. 189:3081-3090(2007). CC -!- FUNCTION: Mnh complex is a Na(+)Li(+)/H(+) antiporter involved in CC Na(+) and/or Li(+) excretion. Na(+)/H(+) antiport consumes a CC transmembrane electrical potential, and is thus inferred to be CC electrogenic. Does not transport K(+), Ca(2+) or Mg(2+). CC -!- ENZYME REGULATION: Na(+) extrusion is completely inhibited by the CC H(+) conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP). CC -!- SUBUNIT: May form a heterooligomeric complex that consists of CC seven subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and CC mnhG1. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein CC (Potential). CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB015981; BAA35095.1; -; Genomic_DNA. DR EMBL; DQ659238; ABG67110.1; -; Genomic_DNA. DR TCDB; 2.A.63.1.3; monovalent cation (K+ or Na+):proton antiporter-3 (CPA3) family. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW. DR GO; GO:0015078; F:hydrogen ion transmembrane transporter acti...; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro. DR GO; GO:0031402; F:sodium ion binding; IEA:UniProtKB-KW. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro. DR GO; GO:0030004; P:cellular monovalent inorganic cation homeos...; IEA:InterPro. DR GO; GO:0015992; P:proton transport; IEA:UniProtKB-KW. DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW. DR InterPro; IPR005663; Antiport_monoval. DR InterPro; IPR003945; NADHpl_OxRdtase_5. DR InterPro; IPR003916; NADHub_OxRdtase_5. DR InterPro; IPR001750; Oxidored_q1. DR InterPro; IPR001516; OxRdtase_q1_N. DR Pfam; PF00361; Oxidored_q1; 1. DR Pfam; PF00662; Oxidored_q1_N; 1. DR PRINTS; PR01434; NADHDHGNASE5. DR PRINTS; PR01435; NPOXDRDTASE5. DR TIGRFAMs; TIGR00940; 2a6301s01; 1. PE 1: Evidence at protein level; KW Antiport; Cell membrane; Hydrogen ion transport; Ion transport; KW Membrane; Sodium; Sodium transport; Transmembrane; Transport. FT CHAIN 1 801 Na(+)/H(+) antiporter subunit A1. FT /FTId=PRO_0000217071. FT TRANSMEM 4 25 Potential. FT TRANSMEM 30 49 Potential. FT TRANSMEM 79 101 Potential. FT TRANSMEM 108 127 Potential. FT TRANSMEM 131 153 Potential. FT TRANSMEM 166 188 Potential. FT TRANSMEM 208 230 Potential. FT TRANSMEM 243 265 Potential. FT TRANSMEM 270 289 Potential. FT TRANSMEM 302 324 Potential. FT TRANSMEM 339 361 Potential. FT TRANSMEM 373 395 Potential. FT TRANSMEM 429 451 Potential. FT TRANSMEM 472 494 Potential. FT TRANSMEM 526 548 Potential. FT TRANSMEM 589 611 Potential. FT TRANSMEM 621 641 Potential. FT TRANSMEM 646 668 Potential. FT TRANSMEM 672 694 Potential. FT TRANSMEM 707 729 Potential. FT TRANSMEM 767 784 Potential. SQ SEQUENCE 801 AA; 89386 MW; 2EEC9AED745917AC CRC64; MSLLHIAVIL PLIFALIIPI LYRFFKRIHL GWFVLSVPIV IFIYMLTLIK TTMSGNTVMK TLNWMPHFGM NFDLYLDGLG LLFSLLISGI GSLVVLYSIG YLSKSEQLGN FYCYLLLFMG AMLGVVLSDN VIILYLFWEL TSFSSFLLIS FWRERQASIY GAQKSLIITV FGGLSLLGGI ILLAIPTQSF SIQYMIQHAS EIQNSPFFIF AMILIMIGAF TKSAQFPFYI WLPDAMEAPT PVSAYLHSAT MVKAGLYLIA RMTPIFAASQ GWVWTVTLVG LITLFWASLN ATKQQDLKGI LAFSTVSQLG MIMAMLGIGA ISYHYQGDDS KIYAAAFTAA IFHLINHATF KGALFMITGA VDHSTGTRDV KKLGGLLTIM PISFTITVIT ALSMAGVPPF NGFLSKESFL ETTFTASQAN LFSVDTLGYL FPIIGIVGSV FTFVYSIKFI MHIFFGQYKP EQLPKKAHEV SILMLLSPAI LATLVIVFGL FPGILTNSII EPATSSINHT VIDDVEFHMF HGLTPAFLST LVIYILGILL IVTFSYWVKL LQRQPGKLTF NYWYNRSANV IPNYSEKMTN SYVTDYSRNN LVIIFGALIL LTFVTIFSVP FNINFKDVSP IRIFEVCIVI LLLSAAFLIL FAKSRLFSII MLSAVGYAVS VLFIFFKAPD LALTQFVVES ISTALFLLCF YHLPNLNRYN EKRSFQLTNA LIAGGVGLSV IIIGLIAYGN RHFESISKFY QEHVYDLAHG KNMVNVILVD FRGMDTLFES SVLGIAGLAV YTMIKLRKKR QTQGNEVKNH E //