ID MNHA_STAAU STANDARD; PRT; 801 AA. AC Q9ZNG6; DT 05-JUL-2004 (Rel. 44, Created) DT 05-JUL-2004 (Rel. 44, Last sequence update) DT 24-JAN-2006 (Rel. 49, Last annotation update) DE Na(+)/H(+) antiporter subunit A (Mnh complex subunit A). GN Name=mnhA; OS Staphylococcus aureus. OC Bacteria; Firmicutes; Bacillales; Staphylococcus. OX NCBI_TaxID=1280; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=209P; RX MEDLINE=99069340; PubMed=9852009; RA Hiramatsu T., Kodama K., Kuroda T., Mizushima T., Tsuchiya T.; RT "A putative multisubunit Na+/H+ antiporter from Staphylococcus RT aureus."; RL J. Bacteriol. 180:6642-6648(1998). CC -!- FUNCTION: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) CC excretion. CC -!- ENZYME REGULATION: Na(+) extrusion is completely inhibited by the CC H(+) conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP). CC -!- SUBUNIT: May form a hetero-oligomeric complex that consists of CC seven subunits: mnhA, mnhB, mnhC, mnhD, mnhE, mnhF and mnhG. CC -!- SUBCELLULAR LOCATION: Integral membrane protein (Potential). CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB015981; BAA35095.1; -; Genomic_DNA. DR InterPro; IPR005663; Antiport_monoval. DR InterPro; IPR003945; NADHpl_oxred5. DR InterPro; IPR003916; NADHub_oxred5. DR InterPro; IPR001750; Oxidored_q1. DR InterPro; IPR001516; Oxidored_q1_N. DR Pfam; PF00361; Oxidored_q1; 1. DR Pfam; PF00662; Oxidored_q1_N; 1. DR PRINTS; PR01434; NADHDHGNASE5. DR PRINTS; PR01435; NPOXDRDTASE5. DR TIGRFAMs; TIGR00940; 2a6301s01; 1. KW Antiport; Hydrogen ion transport; Ion transport; Membrane; Sodium; KW Sodium transport; Transmembrane; Transport. FT TRANSMEM 4 25 Potential. FT TRANSMEM 30 49 Potential. FT TRANSMEM 79 101 Potential. FT TRANSMEM 108 127 Potential. FT TRANSMEM 131 153 Potential. FT TRANSMEM 166 188 Potential. FT TRANSMEM 208 230 Potential. FT TRANSMEM 243 265 Potential. FT TRANSMEM 270 289 Potential. FT TRANSMEM 302 324 Potential. FT TRANSMEM 339 361 Potential. FT TRANSMEM 373 395 Potential. FT TRANSMEM 429 451 Potential. FT TRANSMEM 472 494 Potential. FT TRANSMEM 526 548 Potential. FT TRANSMEM 589 611 Potential. FT TRANSMEM 621 641 Potential. FT TRANSMEM 646 668 Potential. FT TRANSMEM 672 694 Potential. FT TRANSMEM 707 729 Potential. FT TRANSMEM 767 784 Potential. SQ SEQUENCE 801 AA; 89386 MW; 2EEC9AED745917AC CRC64; MSLLHIAVIL PLIFALIIPI LYRFFKRIHL GWFVLSVPIV IFIYMLTLIK TTMSGNTVMK TLNWMPHFGM NFDLYLDGLG LLFSLLISGI GSLVVLYSIG YLSKSEQLGN FYCYLLLFMG AMLGVVLSDN VIILYLFWEL TSFSSFLLIS FWRERQASIY GAQKSLIITV FGGLSLLGGI ILLAIPTQSF SIQYMIQHAS EIQNSPFFIF AMILIMIGAF TKSAQFPFYI WLPDAMEAPT PVSAYLHSAT MVKAGLYLIA RMTPIFAASQ GWVWTVTLVG LITLFWASLN ATKQQDLKGI LAFSTVSQLG MIMAMLGIGA ISYHYQGDDS KIYAAAFTAA IFHLINHATF KGALFMITGA VDHSTGTRDV KKLGGLLTIM PISFTITVIT ALSMAGVPPF NGFLSKESFL ETTFTASQAN LFSVDTLGYL FPIIGIVGSV FTFVYSIKFI MHIFFGQYKP EQLPKKAHEV SILMLLSPAI LATLVIVFGL FPGILTNSII EPATSSINHT VIDDVEFHMF HGLTPAFLST LVIYILGILL IVTFSYWVKL LQRQPGKLTF NYWYNRSANV IPNYSEKMTN SYVTDYSRNN LVIIFGALIL LTFVTIFSVP FNINFKDVSP IRIFEVCIVI LLLSAAFLIL FAKSRLFSII MLSAVGYAVS VLFIFFKAPD LALTQFVVES ISTALFLLCF YHLPNLNRYN EKRSFQLTNA LIAGGVGLSV IIIGLIAYGN RHFESISKFY QEHVYDLAHG KNMVNVILVD FRGMDTLFES SVLGIAGLAV YTMIKLRKKR QTQGNEVKNH E //