ID APOC3_CAVPO Reviewed; 91 AA. AC Q9Z2R5; DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 1. DT 16-MAR-2016, entry version 84. DE RecName: Full=Apolipoprotein C-III; DE Short=Apo-CIII; DE Short=ApoC-III; DE AltName: Full=Apolipoprotein C3; DE Flags: Precursor; GN Name=APOC3; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricognathi; Caviidae; Cavia. OX NCBI_TaxID=10141; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Liver; RX PubMed=10584299; DOI=10.1016/S0305-0491(99)00097-8; RA Yin Y., Olivecrona G.; RT "Apolipoprotein CIII from guinea pig (Cavia porcellus) is shorter and RT less homologous than apolipoprotein CIII from other mammals."; RL Comp. Biochem. Physiol. 124B:157-161(1999). CC -!- FUNCTION: Component of triglyceride-rich very low density CC lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. CC Plays a multifaceted role in triglyceride homeostasis. CC Intracellularly, promotes hepatic very low density lipoprotein 1 CC (VLDL1) assembly and secretion; extracellularly, attenuates CC hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). CC Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and CC the hepatic uptake of TRLs by remnant receptors. CC {ECO:0000250|UniProtKB:P02656}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02656}. CC -!- SIMILARITY: Belongs to the apolipoprotein C3 family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF030571; AAD01908.1; -; mRNA. DR RefSeq; NP_001166386.1; NM_001172915.1. DR RefSeq; XP_013010825.1; XM_013155371.1. DR ProteinModelPortal; Q9Z2R5; -. DR STRING; 10141.ENSCPOP00000016494; -. DR Ensembl; ENSCPOT00000027097; ENSCPOP00000016494; ENSCPOG00000025900. DR GeneID; 100135481; -. DR CTD; 345; -. DR eggNOG; ENOG410JE3N; Eukaryota. DR eggNOG; ENOG4111APE; LUCA. DR GeneTree; ENSGT00390000015395; -. DR HOGENOM; HOG000247042; -. DR HOVERGEN; HBG050549; -. DR InParanoid; Q9Z2R5; -. DR OMA; SLKDYWS; -. DR OrthoDB; EOG7JMGHK; -. DR TreeFam; TF338209; -. DR Proteomes; UP000005447; Unassembled WGS sequence. DR GO; GO:0042627; C:chylomicron; IEA:UniProtKB-KW. DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl. DR GO; GO:0034363; C:intermediate-density lipoprotein particle; IEA:Ensembl. DR GO; GO:0034366; C:spherical high-density lipoprotein particle; IEA:Ensembl. DR GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW. DR GO; GO:0055102; F:lipase inhibitor activity; IEA:Ensembl. DR GO; GO:0005543; F:phospholipid binding; IEA:Ensembl. DR GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl. DR GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl. DR GO; GO:0008203; P:cholesterol metabolic process; IEA:Ensembl. DR GO; GO:0034382; P:chylomicron remnant clearance; IEA:Ensembl. DR GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Ensembl. DR GO; GO:0034375; P:high-density lipoprotein particle remodeling; IEA:Ensembl. DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro. DR GO; GO:0060621; P:negative regulation of cholesterol import; IEA:Ensembl. DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:Ensembl. DR GO; GO:0010987; P:negative regulation of high-density lipoprotein particle clearance; IEA:Ensembl. DR GO; GO:0051005; P:negative regulation of lipoprotein lipase activity; IEA:Ensembl. DR GO; GO:0010989; P:negative regulation of low-density lipoprotein particle clearance; IEA:Ensembl. DR GO; GO:0048261; P:negative regulation of receptor-mediated endocytosis; IEA:Ensembl. DR GO; GO:0010897; P:negative regulation of triglyceride catabolic process; IEA:Ensembl. DR GO; GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IEA:Ensembl. DR GO; GO:0033700; P:phospholipid efflux; IEA:Ensembl. DR GO; GO:0032489; P:regulation of Cdc42 protein signal transduction; IEA:Ensembl. DR GO; GO:0019433; P:triglyceride catabolic process; IEA:Ensembl. DR GO; GO:0070328; P:triglyceride homeostasis; IEA:Ensembl. DR GO; GO:0006642; P:triglyceride mobilization; IEA:Ensembl. DR Gene3D; 1.10.1440.10; -; 1. DR InterPro; IPR008403; Apo-CIII. DR InterPro; IPR023121; ApoC-II_domain. DR PANTHER; PTHR14225; PTHR14225; 1. DR Pfam; PF05778; Apo-CIII; 1. DR ProDom; PD010414; Apo-CIII; 1. PE 3: Inferred from homology; KW Chylomicron; Complete proteome; Lipid degradation; Lipid metabolism; KW Lipid transport; Oxidation; Reference proteome; Secreted; Signal; KW Transport; VLDL. FT SIGNAL 1 20 {ECO:0000250}. FT CHAIN 21 91 Apolipoprotein C-III. FT /FTId=PRO_0000002030. FT REGION 68 91 Lipid-binding. {ECO:0000250}. FT MOD_RES 63 63 Methionine sulfoxide. FT {ECO:0000250|UniProtKB:P33622}. SQ SEQUENCE 91 AA; 10099 MW; 849C2BBD4783E8FF CRC64; MQPRVLLAVT LLALLVSARA EEIQESSLLG VMKDYMQQAS KTANEMLTKV QESQVAENAR EWMTESLDSM KGYWTSLIGR LSGFLDSTPS S //