ID APOC3_CAVPO STANDARD; PRT; 91 AA. AC Q9Z2R5; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 24-JAN-2006 (Rel. 49, Last annotation update) DE Apolipoprotein C-III precursor (Apo-CIII) (ApoC-III). GN Name=APOC3; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricognathi; Caviidae; Cavia. OX NCBI_TaxID=10141; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Liver; RX MEDLINE=20051688; PubMed=10584299; DOI=10.1016/S0305-0491(99)00097-8; RA Yin Y., Olivecrona G.; RT "Apolipoprotein CIII from guinea pig (Cavia porcellus) is shorter and RT less homologous than apolipoprotein CIII from other mammals."; RL Comp. Biochem. Physiol. 124B:157-161(1999). CC -!- FUNCTION: Inhibits lipoprotein lipase and hepatic lipase and CC decreases the uptake of lymph chylomicrons by hepatic cells. This CC suggests that it delays the catabolism of triglyceride-rich CC particles (By similarity). CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- TISSUE SPECIFICITY: Mainly VLDL and also in HDL. Synthesized CC predominantly in liver and to a lesser degree in intestine. CC -!- SIMILARITY: Belongs to the apolipoprotein C3 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF030571; AAD01908.1; -; mRNA. DR InterPro; IPR008403; Apo-CIII. DR InterPro; IPR000074; ApoA1_A4_E. DR PANTHER; PTHR14225; Apo-CIII; 1. DR Pfam; PF05778; Apo-CIII; 1. KW Chylomicron; Lipid degradation; Lipid transport; Signal; Transport; KW VLDL. FT SIGNAL 1 20 By similarity. FT CHAIN 21 91 Apolipoprotein C-III. FT /FTId=PRO_0000002030. FT REGION 68 91 Lipid-binding (By similarity). SQ SEQUENCE 91 AA; 10099 MW; 849C2BBD4783E8FF CRC64; MQPRVLLAVT LLALLVSARA EEIQESSLLG VMKDYMQQAS KTANEMLTKV QESQVAENAR EWMTESLDSM KGYWTSLIGR LSGFLDSTPS S //