ID CLIC1_MOUSE Reviewed; 240 AA. AC Q9Z1Q5; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 13-SEP-2004, sequence version 2. DT 31-OCT-2006, entry version 46. DE Chloride intracellular channel protein 1 (Nuclear chloride ion channel DE 27) (NCC27). GN Name=Clic1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=129; RX PubMed=14656967; DOI=10.1101/gr.1736803; RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., RA Campbell R.D., Hood L.; RT "Analysis of the gene-dense major histocompatibility complex class III RT region and its comparison to mouse."; RL Genome Res. 13:2621-2636(2003). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N; TISSUE=Mammary gland; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Seems to act as a chloride ion channel (By similarity). CC -!- INTERACTION: CC P70181:Pip5k1a; NbExp=2; IntAct=EBI-645184, EBI-645167; CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By CC similarity). CC -!- SIMILARITY: Belongs to the chloride channel CLIC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF109905; AAC84155.1; -; Genomic_DNA. DR EMBL; BC004658; AAH04658.1; -; mRNA. DR UniGene; Mm.29524; -. DR HSSP; O00299; 1K0O. DR SMR; Q9Z1Q5; 5-240. DR IntAct; Q9Z1Q5; -. DR Ensembl; ENSMUSG00000007041; Mus musculus. DR KEGG; mmu:114584; -. DR MGI; MGI:2148924; Clic1. DR ArrayExpress; Q9Z1Q5; -. DR RZPD-ProtExp; IOM18201; -. DR GO; GO:0005903; C:brush border; ISS:UniProtKB. DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB. DR GO; GO:0005624; C:membrane fraction; ISS:UniProtKB. DR GO; GO:0005625; C:soluble fraction; ISS:UniProtKB. DR GO; GO:0005515; F:protein binding; IPI:IntAct. DR InterPro; IPR010987; GST_C_like. DR InterPro; IPR002946; Int_Cl_channel. DR InterPro; IPR012336; Thiordxn-like_fd. DR InterPro; IPR012335; Thioredoxin_fold. DR PRINTS; PR01263; INTCLCHANNEL. DR TIGRFAMs; TIGR00862; O-ClC; 1. KW Acetylation; Chloride; Chloride channel; Ion transport; Ionic channel; KW Nuclear protein; Transport; Voltage-gated channel. FT INIT_MET 0 0 By similarity. FT CHAIN 1 240 Chloride intracellular channel protein 1. FT /FTId=PRO_0000144202. FT MOD_RES 1 1 N-acetylalanine (By similarity). SQ SEQUENCE 240 AA; 26882 MW; EDB43BA5FD13C071 CRC64; AEEQPQVELF VKAGSDGAKI GNCPFSQRLF MVLWLKGVTF NVTTVDTKRR TETVQKLCPG GQLPFLLYGT EVHTDTNKIE EFLEAMLCPP RYPKLAALNP ESNTSGLDIF AKFSAYIKNS NPALNDNLEK GLLKALKVLD NYLTSPLPEE VDETSAEDEG ISQRKFLDGN ELTLADCNLL PKLHIVQVVC KKYRGFTIPE AFRGVHRYLS NAYAREEFAS TCPDDEEIEL AYEQVARALK //