ID CLIC1_MOUSE STANDARD; PRT; 240 AA. AC Q9Z1Q5; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 13-SEP-2004, sequence version 2. DT 05-SEP-2006, entry version 43. DE Chloride intracellular channel protein 1 (Nuclear chloride ion channel DE 27) (NCC27). GN Name=Clic1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=129; RX PubMed=14656967; DOI=10.1101/gr.1736803; RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., RA Campbell R.D., Hood L.; RT "Analysis of the gene-dense major histocompatibility complex class III RT region and its comparison to mouse."; RL Genome Res. 13:2621-2636(2003). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N; TISSUE=Mammary gland; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Seems to act as a chloride ion channel (By similarity). CC -!- INTERACTION: CC P70181:Pip5k1a; NbExp=2; IntAct=EBI-645184, EBI-645167; CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By CC similarity). CC -!- SIMILARITY: Belongs to the chloride channel CLIC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF109905; AAC84155.1; -; Genomic_DNA. DR EMBL; BC004658; AAH04658.1; -; mRNA. DR UniGene; Mm.29524; -. DR HSSP; O00299; 1K0O. DR SMR; Q9Z1Q5; 5-240. DR IntAct; Q9Z1Q5; -. DR Ensembl; ENSMUSG00000007041; Mus musculus. DR MGI; MGI:2148924; Clic1. DR ArrayExpress; Q9Z1Q5; -. DR RZPD-ProtExp; IOM18201; -. DR GO; GO:0005903; C:brush border; ISS. DR GO; GO:0005737; C:cytoplasm; ISS. DR GO; GO:0005624; C:membrane fraction; ISS. DR GO; GO:0005625; C:soluble fraction; ISS. DR GO; GO:0005515; F:protein binding; IPI. DR InterPro; IPR010987; GST_C_like. DR InterPro; IPR002946; Int_Cl_channel. DR InterPro; IPR012336; Thiordxn-like_fd. DR InterPro; IPR012335; Thioredoxin_fold. DR PRINTS; PR01263; INTCLCHANNEL. DR TIGRFAMs; TIGR00862; O-ClC; 1. KW Acetylation; Chloride; Chloride channel; Ion transport; Ionic channel; KW Nuclear protein; Transport; Voltage-gated channel. FT INIT_MET 0 0 By similarity. FT CHAIN 1 240 Chloride intracellular channel protein 1. FT /FTId=PRO_0000144202. FT MOD_RES 1 1 N-acetylalanine (By similarity). SQ SEQUENCE 240 AA; 26882 MW; EDB43BA5FD13C071 CRC64; AEEQPQVELF VKAGSDGAKI GNCPFSQRLF MVLWLKGVTF NVTTVDTKRR TETVQKLCPG GQLPFLLYGT EVHTDTNKIE EFLEAMLCPP RYPKLAALNP ESNTSGLDIF AKFSAYIKNS NPALNDNLEK GLLKALKVLD NYLTSPLPEE VDETSAEDEG ISQRKFLDGN ELTLADCNLL PKLHIVQVVC KKYRGFTIPE AFRGVHRYLS NAYAREEFAS TCPDDEEIEL AYEQVARALK //