ID MDS1_MOUSE Reviewed; 129 AA. AC Q9Z1L8; DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 1. DT 16-SEP-2015, entry version 86. DE RecName: Full=MDS1 and EVI1 complex locus protein MDS1; DE AltName: Full=Myelodysplasia syndrome 1 protein homolog; GN Name=Mecom; Synonyms=Mds1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=9837768; DOI=10.1006/bbrc.1998.9588; RA Wimmer K., Vinatzer U., Zwirn P., Fonatsch C., Wieser R.; RT "Comparative expression analysis of the antagonistic transcription RT factors EVI1 and MDS1-EVI1 in murine tissues and during in vitro RT hematopoietic differentiation."; RL Biochem. Biophys. Res. Commun. 252:691-696(1998). RN [2] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Kidney, and Lung; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative promoter usage, Alternative splicing; Named isoforms=2; CC Name=2; CC IsoId=Q9Z1L8-1; Sequence=Displayed; CC Note=Produced by alternative promoter usage. May be due to CC intron retention.; CC Name=1; CC IsoId=P14404-1; Sequence=External; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ010015; CAA08971.1; -; mRNA. DR RefSeq; NP_067417.1; NM_021442.2. [Q9Z1L8-1] DR UniGene; Mm.426829; -. DR UniGene; Mm.56965; -. DR ProteinModelPortal; Q9Z1L8; -. DR SMR; Q9Z1L8; 78-116. DR BioGrid; 199542; 2. DR PhosphoSite; Q9Z1L8; -. DR MaxQB; Q9Z1L8; -. DR PRIDE; Q9Z1L8; -. DR GeneID; 14013; -. DR UCSC; uc008ouv.1; mouse. [Q9Z1L8-1] DR CTD; 2122; -. DR MGI; MGI:95457; Mecom. DR eggNOG; NOG40641; -. DR HOVERGEN; HBG031707; -. DR PhylomeDB; Q9Z1L8; -. DR ChiTaRS; Mecom; mouse. DR NextBio; 284928; -. DR Proteomes; UP000000589; Unplaced. DR CleanEx; MM_MDS1; -. DR Genevisible; Q9Z1L8; MM. DR GO; GO:0016235; C:aggresome; ISO:MGI. DR GO; GO:0005737; C:cytoplasm; ISO:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI. DR GO; GO:0016607; C:nuclear speck; ISO:MGI. DR GO; GO:0005654; C:nucleoplasm; ISO:MGI. DR GO; GO:0005634; C:nucleus; ISO:MGI. DR GO; GO:0003677; F:DNA binding; IDA:MGI. DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISO:MGI. DR GO; GO:0035115; P:embryonic forelimb morphogenesis; IMP:MGI. DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; IMP:MGI. DR GO; GO:0030900; P:forebrain development; IMP:MGI. DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI. DR GO; GO:0006954; P:inflammatory response; IMP:MGI. DR GO; GO:0046329; P:negative regulation of JNK cascade; ISO:MGI. DR GO; GO:0043069; P:negative regulation of programmed cell death; ISO:MGI. DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI. DR GO; GO:0001780; P:neutrophil homeostasis; IMP:MGI. DR GO; GO:0060039; P:pericardium development; IMP:MGI. DR GO; GO:0090336; P:positive regulation of brown fat cell differentiation; IMP:MGI. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI. DR GO; GO:0009791; P:post-embryonic development; IMP:MGI. DR GO; GO:0051726; P:regulation of cell cycle; ISO:MGI. DR GO; GO:0042127; P:regulation of cell proliferation; IMP:MGI. DR GO; GO:0072001; P:renal system development; IGI:MGI. DR GO; GO:0009617; P:response to bacterium; IMP:MGI. DR GO; GO:0019827; P:stem cell maintenance; IGI:MGI. DR InterPro; IPR026710; MDS1. DR PANTHER; PTHR21652; PTHR21652; 1. PE 1: Evidence at protein level; KW Alternative promoter usage; Alternative splicing; Complete proteome; KW Reference proteome. FT CHAIN 1 129 MDS1 and EVI1 complex locus protein MDS1. FT /FTId=PRO_0000096339. SQ SEQUENCE 129 AA; 14329 MW; 812CD5EB59C36A6E CRC64; MRSKGRARKL ATSNECAYGN YPEIPLEEMP DADADGITSV PSLHIQEPCS PATSSESFTP KEGSPYKAPI YIPDDIPIPD EFELRESTMP GAGLGIWTKR KIEIGEKFGP YMGEQRSDLK DSSYGWENR //