ID IGSF6_RAT Reviewed; 238 AA. AC Q9Z0K5; DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 1. DT 15-DEC-2009, entry version 55. DE RecName: Full=Immunoglobulin superfamily member 6; DE AltName: Full=Protein DORA; DE Flags: Precursor; GN Name=Igsf6; Synonyms=Dora; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=99025433; PubMed=9809579; DOI=10.1016/S0161-5890(98)00045-5; RA Bates E.E.M., Dieu M.-C., Ravel O., Zurawski S.M., Patel S., RA Bridon J.-M., Ait-Yahia S., Vega F. Jr., Banchereau J., Lebecque S.; RT "CD40L activation of dendritic cells down-regulates DORA, a novel RT member of the immunoglobulin superfamily."; RL Mol. Immunol. 35:513-524(1998). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein (Potential). CC -!- MISCELLANEOUS: This gene is coded entirely within the intron of CC Mettl9 which is transcribed in the opposite strand of the DNA. CC -!- SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) CC domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ223184; CAA11156.1; -; mRNA. DR IPI; IPI00207822; -. DR RefSeq; NP_598226.1; -. DR UniGene; Rn.204094; -. DR Ensembl; ENSRNOT00000023262; ENSRNOP00000023262; ENSRNOG00000017277; Rattus norvegicus. DR GeneID; 171064; -. DR KEGG; rno:171064; -. DR UCSC; NM_133542; rat. DR CTD; 171064; -. DR RGD; 620663; Igsf6. DR HOVERGEN; Q9Z0K5; -. DR InParanoid; Q9Z0K5; -. DR NextBio; 621653; -. DR ArrayExpress; Q9Z0K5; -. DR Genevestigator; Q9Z0K5; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR013106; Ig_V-set. DR Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1. DR Pfam; PF07686; V-set; 1. DR SMART; SM00409; IG; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Disulfide bond; Immunoglobulin domain; Membrane; Signal; KW Transmembrane. FT SIGNAL 1 27 Potential. FT CHAIN 28 238 Immunoglobulin superfamily member 6. FT /FTId=PRO_5000065015. FT TOPO_DOM 28 153 Extracellular (Potential). FT TRANSMEM 154 174 Potential. FT TOPO_DOM 175 238 Cytoplasmic (Potential). FT DOMAIN 30 134 Ig-like C2-type. FT DISULFID 51 118 By similarity. SQ SEQUENCE 238 AA; 26433 MW; 02C661D53755DECC CRC64; MGPVSTSRRG LRLGISLILL QVGVVGACTV SVLQPGYLEV DYTSQTVTME CTFSTTGCPA VQPKSLWFRC GTHQPEALCL DGCRNEADKF TVKETLDQNR VSLTVNRLSP NDSAIYICGI AFPNEPVPTA KQTGDGTTLV VRERLFSREV HSLLIVLLAL LAVYVTGVCV IFIVLFRSKS NTPRSRETKE DSKKKSARRI FQEIAQELYH KRYVETSHQP EQDGNYENRK ALPSPGRP //