ID IGSF6_RAT Reviewed; 238 AA. AC Q9Z0K5; DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 1. DT 24-JAN-2024, entry version 108. DE RecName: Full=Immunoglobulin superfamily member 6; DE Short=IgSF6; DE AltName: Full=Protein DORA; DE Flags: Precursor; GN Name=Igsf6; Synonyms=Dora; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=9809579; DOI=10.1016/s0161-5890(98)00045-5; RA Bates E.E.M., Dieu M.-C., Ravel O., Zurawski S.M., Patel S., Bridon J.-M., RA Ait-Yahia S., Vega F. Jr., Banchereau J., Lebecque S.; RT "CD40L activation of dendritic cells down-regulates DORA, a novel member of RT the immunoglobulin superfamily."; RL Mol. Immunol. 35:513-524(1998). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I CC membrane protein {ECO:0000305}. CC -!- MISCELLANEOUS: This gene is coded entirely within the intron of Mettl9 CC which is transcribed in the opposite strand of the DNA. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ223184; CAA11156.1; -; mRNA. DR RefSeq; NP_598226.1; NM_133542.2. DR AlphaFoldDB; Q9Z0K5; -. DR SMR; Q9Z0K5; -. DR STRING; 10116.ENSRNOP00000023262; -. DR PhosphoSitePlus; Q9Z0K5; -. DR PaxDb; 10116-ENSRNOP00000023262; -. DR GeneID; 171064; -. DR KEGG; rno:171064; -. DR UCSC; RGD:620663; rat. DR AGR; RGD:620663; -. DR CTD; 10261; -. DR RGD; 620663; Igsf6. DR eggNOG; ENOG502S4JY; Eukaryota. DR InParanoid; Q9Z0K5; -. DR OrthoDB; 5301240at2759; -. DR PhylomeDB; Q9Z0K5; -. DR PRO; PR:Q9Z0K5; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR013106; Ig_V-set. DR InterPro; IPR039089; IGSF6. DR PANTHER; PTHR15297; IMMUNOGLOBULIN SUPERFAMILY MEMBER 6; 1. DR PANTHER; PTHR15297:SF2; IMMUNOGLOBULIN SUPERFAMILY MEMBER 6; 1. DR Pfam; PF07686; V-set; 1. DR SMART; SM00409; IG; 1. DR SMART; SM00406; IGv; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Disulfide bond; Immunoglobulin domain; Membrane; Reference proteome; KW Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1..27 FT /evidence="ECO:0000255" FT CHAIN 28..238 FT /note="Immunoglobulin superfamily member 6" FT /id="PRO_5000065015" FT TOPO_DOM 28..153 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 154..174 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 175..238 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT DOMAIN 30..134 FT /note="Ig-like C2-type" FT REGION 215..238 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 51..118 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" SQ SEQUENCE 238 AA; 26433 MW; 02C661D53755DECC CRC64; MGPVSTSRRG LRLGISLILL QVGVVGACTV SVLQPGYLEV DYTSQTVTME CTFSTTGCPA VQPKSLWFRC GTHQPEALCL DGCRNEADKF TVKETLDQNR VSLTVNRLSP NDSAIYICGI AFPNEPVPTA KQTGDGTTLV VRERLFSREV HSLLIVLLAL LAVYVTGVCV IFIVLFRSKS NTPRSRETKE DSKKKSARRI FQEIAQELYH KRYVETSHQP EQDGNYENRK ALPSPGRP //