ID Q9YNB8_9HIV1 Unreviewed; 192 AA. AC Q9YNB8; DT 01-MAY-1999, integrated into UniProtKB/TrEMBL. DT 01-MAY-1999, sequence version 1. DT 11-DEC-2019, entry version 81. DE RecName: Full=Protein Nef {ECO:0000256|RuleBase:RU000344, ECO:0000256|SAAS:SAAS01051655}; DE Flags: Fragment; GN Name=nef {ECO:0000313|EMBL:CAA76052.1}; OS Human immunodeficiency virus 1. OC Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:CAA76052.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:CAA76052.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Ukrainian {ECO:0000313|EMBL:CAA76052.1}; RA Grebenjuk V.A., Anoprienko O.V., Skorokhod A.S., Marichev I.L., RA Kavsan V.M.; RT "Genetic characterization of HIV-1 variants in Ukraine [in Russian]."; RL Biopolim. Kletka 14:277-285(1998). CC -!- SUBUNIT: Homodimer. {ECO:0000256|SAAS:SAAS01051624}. CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|SAAS:SAAS01051622}; Lipid-anchor CC {ECO:0000256|SAAS:SAAS01051622}; Cytoplasmic side CC {ECO:0000256|SAAS:SAAS01051622}. CC -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein family. CC {ECO:0000256|RuleBase:RU000344, ECO:0000256|SAAS:SAAS01051605}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y16086; CAA76052.1; -; Genomic_DNA. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0005525; F:GTP binding; IEA:InterPro. DR GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW. DR GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW. DR Gene3D; 3.30.62.10; -; 1. DR Gene3D; 4.10.890.10; -; 1. DR InterPro; IPR027480; HIV-1_Nef_anchor_sf. DR InterPro; IPR027481; HIV-1_Nef_core_sf. DR InterPro; IPR001558; HIV_Nef. DR Pfam; PF00469; F-protein; 1. DR SUPFAM; SSF55671; SSF55671; 1. PE 3: Inferred from homology; KW Host cell membrane {ECO:0000256|SAAS:SAAS01051610}; KW Host membrane {ECO:0000256|SAAS:SAAS01051635}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS01051595}; KW Lipoprotein {ECO:0000256|RuleBase:RU000344}; KW Membrane {ECO:0000256|SAAS:SAAS01051602}; KW Myristate {ECO:0000256|RuleBase:RU000344}; KW Viral immunoevasion {ECO:0000256|RuleBase:RU000344}; KW Virulence {ECO:0000256|RuleBase:RU000344}. FT REGION 1..26 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..18 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:CAA76052.1" FT NON_TER 192 FT /evidence="ECO:0000313|EMBL:CAA76052.1" SQ SEQUENCE 192 AA; 21989 MW; ADD96A97BB1DFA8B CRC64; KRMPGWNTVR ERMHRAEPAA DGVGAASRDL EKHGAITSNN TAATNPDVAW LEAQQEEEEV GFPVRPQVPL RPMTYKGALD LSHFLREKGG LEGLVYSQKR KEILDPWVYN TRGYFPDWHN YTPGPGVRYP LCFGWCFKLV PVEPEEVEKA NEGENNCLLH PISLHGIDDP EKEVLEWRFD SRLAFHHVAR EM //