ID Q9YNB8 PRELIMINARY; PRT; 192 AA. AC Q9YNB8; DT 01-MAY-1999 (TrEMBLrel. 10, Created) DT 01-MAY-1999 (TrEMBLrel. 10, Last sequence update) DT 01-MAR-2002 (TrEMBLrel. 20, Last annotation update) DE NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (FRAGMENT). GN NEF. OS Human immunodeficiency virus type 1. OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11676; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=UKRAINIAN; RA Grebenjuk V.A., Anoprienko O.V., Skorokhod A.S., Marichev I.L., RA Kavsan V.M.; RT "Genetic characterization of HIV-1 variants in Ukraine [in Russian]."; RL Biopolymers & Cell 14:277-285(1998). CC -!- SIMILARITY: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING CC ACTIVITIES, IT SEEMS TO DOWN-REGULATE THE CD4(T4) ANTIGEN. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y16086; CAA76052.1; -. DR HSSP; P03406; 1EFN. DR InterPro; IPR001558; HIV_Nef. DR Pfam; PF00469; F-protein; 1. DR ProDom; PD000031; F-protein; 1. KW AIDS; GTP-binding; Myristate. FT NON_TER 1 1 FT NON_TER 192 192 SQ SEQUENCE 192 AA; 21989 MW; ADD96A97BB1DFA8B CRC64; KRMPGWNTVR ERMHRAEPAA DGVGAASRDL EKHGAITSNN TAATNPDVAW LEAQQEEEEV GFPVRPQVPL RPMTYKGALD LSHFLREKGG LEGLVYSQKR KEILDPWVYN TRGYFPDWHN YTPGPGVRYP LCFGWCFKLV PVEPEEVEKA NEGENNCLLH PISLHGIDDP EKEVLEWRFD SRLAFHHVAR EM //