ID Q9YNB8_9HIV1 Unreviewed; 192 AA. AC Q9YNB8; DT 01-MAY-1999, integrated into UniProtKB/TrEMBL. DT 01-MAY-1999, sequence version 1. DT 17-FEB-2016, entry version 69. DE RecName: Full=Protein Nef {ECO:0000256|RuleBase:RU000344, ECO:0000256|SAAS:SAAS00004511}; DE Flags: Fragment; GN Name=nef {ECO:0000313|EMBL:CAA76052.1}; OS Human immunodeficiency virus 1. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:CAA76052.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:CAA76052.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Ukrainian {ECO:0000313|EMBL:CAA76052.1}; RA Grebenjuk V.A., Anoprienko O.V., Skorokhod A.S., Marichev I.L., RA Kavsan V.M.; RT "Genetic characterization of HIV-1 variants in Ukraine [in Russian]."; RL Biopolim. Kletka 14:277-285(1998). CC -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein CC family. {ECO:0000256|RuleBase:RU000344}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y16086; CAA76052.1; -; Genomic_DNA. DR ProteinModelPortal; Q9YNB8; -. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0005525; F:GTP binding; IEA:InterPro. DR GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW. DR GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW. DR Gene3D; 3.30.62.10; -; 1. DR Gene3D; 4.10.890.10; -; 1. DR InterPro; IPR027480; HIV-1_Nef_anchor. DR InterPro; IPR027481; HIV-1_Nef_core. DR InterPro; IPR001558; HIV_Nef. DR Pfam; PF00469; F-protein; 1. DR SUPFAM; SSF55671; SSF55671; 1. PE 3: Inferred from homology; KW Host cell membrane {ECO:0000256|SAAS:SAAS00417561}; KW Host membrane {ECO:0000256|SAAS:SAAS00417568}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00417537}; KW Lipoprotein {ECO:0000256|RuleBase:RU003609}; KW Membrane {ECO:0000256|SAAS:SAAS00417549}; KW Myristate {ECO:0000256|RuleBase:RU003609}; KW Viral immunoevasion {ECO:0000256|RuleBase:RU000344}; KW Virulence {ECO:0000256|RuleBase:RU000344}. FT NON_TER 1 1 {ECO:0000313|EMBL:CAA76052.1}. FT NON_TER 192 192 {ECO:0000313|EMBL:CAA76052.1}. SQ SEQUENCE 192 AA; 21989 MW; ADD96A97BB1DFA8B CRC64; KRMPGWNTVR ERMHRAEPAA DGVGAASRDL EKHGAITSNN TAATNPDVAW LEAQQEEEEV GFPVRPQVPL RPMTYKGALD LSHFLREKGG LEGLVYSQKR KEILDPWVYN TRGYFPDWHN YTPGPGVRYP LCFGWCFKLV PVEPEEVEKA NEGENNCLLH PISLHGIDDP EKEVLEWRFD SRLAFHHVAR EM //