ID Q9YNB8 PRELIMINARY; PRT; 192 AA. AC Q9YNB8; DT 01-MAY-1999 (TrEMBLrel. 10, Created) DT 01-MAY-1999 (TrEMBLrel. 10, Last sequence update) DT 01-MAR-2001 (TrEMBLrel. 16, Last annotation update) DE NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (FRAGMENT). GN NEF. OS Human immunodeficiency virus type 1. OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11676; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=UKRAINIAN; RA Grebenjuk V.A., Anoprienko O.V., Skorokhod A.S., Marichev I.L., RA Kavsan V.M.; RT "Genetic characterization of HIV-1 variants in Ukraine [in Russian]."; RL Biopolymers & Cell 14:277-285(1998). CC -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING CC ACTIVITIES, IT SEEMS TO DOWN REGULATE THE CD4(T4) ANTIGEN. NEF CC PROTEIN ACCELERATES VIRULENT PROGRESSION OF AIDS BY ITS CC INTERACTION WITH CELLULAR PROTEINS INVOLVED IN SIGNAL TRANSDUCTION CC AND HOST CELL ACTIVATION. NEF HAS BEEN SHOWN TO BIND SPECIFICALLY CC TO A SUBSET OF THE SRC KINASE FAMILY (BY SIMILARITY). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y16086; CAA76052.1; -. DR InterPro; IPR001558; -. DR Pfam; PF00469; F-protein; 1. KW AIDS; GTP-binding; Myristate. FT NON_TER 1 1 FT NON_TER 192 192 SQ SEQUENCE 192 AA; 21989 MW; ADD96A97BB1DFA8B CRC64; KRMPGWNTVR ERMHRAEPAA DGVGAASRDL EKHGAITSNN TAATNPDVAW LEAQQEEEEV GFPVRPQVPL RPMTYKGALD LSHFLREKGG LEGLVYSQKR KEILDPWVYN TRGYFPDWHN YTPGPGVRYP LCFGWCFKLV PVEPEEVEKA NEGENNCLLH PISLHGIDDP EKEVLEWRFD SRLAFHHVAR EM //