ID OPSD_SPAAU Reviewed; 353 AA. AC Q9YH02; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 1. DT 26-MAY-2009, entry version 52. DE RecName: Full=Rhodopsin; GN Name=rho; OS Sparus aurata (Gilthead sea bream). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Percoidei; OC Sparidae; Sparus. OX NCBI_TaxID=8175; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Retina; RA Archer S.N., Hirano J.; RT "Comparative analysis of opsins in Mediterranian coastal fish."; RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y18665; CAA77247.1; -; mRNA. DR HSSP; P02699; 1EDV. DR SMR; Q9YH02; 1-348. DR HOVERGEN; Q9YH02; -. DR GO; GO:0016021; C:integral to membrane; IEA:InterPro. DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; IEA:InterPro. DR GO; GO:0007602; P:phototransduction; IEA:InterPro. DR GO; GO:0018298; P:protein-chromophore linkage; IEA:UniProtKB-KW. DR InterPro; IPR000276; 7TM_GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_supfam. DR InterPro; IPR001760; Opsin. DR InterPro; IPR000732; Rhodopsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. PE 2: Evidence at transcript level; KW Chromophore; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Lipoprotein; Membrane; Palmitate; Phosphoprotein; KW Photoreceptor protein; Receptor; Retinal protein; KW Sensory transduction; Transducer; Transmembrane; Vision. FT CHAIN 1 353 Rhodopsin. FT /FTId=PRO_0000197722. FT TOPO_DOM 1 36 Extracellular. FT TRANSMEM 37 61 1 (Potential). FT TOPO_DOM 62 73 Cytoplasmic. FT TRANSMEM 74 98 2 (Potential). FT TOPO_DOM 99 113 Extracellular. FT TRANSMEM 114 133 3 (Potential). FT TOPO_DOM 134 152 Cytoplasmic. FT TRANSMEM 153 176 4 (Potential). FT TOPO_DOM 177 202 Extracellular. FT TRANSMEM 203 230 5 (Potential). FT TOPO_DOM 231 252 Cytoplasmic. FT TRANSMEM 253 276 6 (Potential). FT TOPO_DOM 277 284 Extracellular. FT TRANSMEM 285 309 7 (Potential). FT TOPO_DOM 310 353 Cytoplasmic. FT MOD_RES 296 296 N6-(retinylidene)lysine (By similarity). FT LIPID 322 322 S-palmitoyl cysteine (By similarity). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 200 200 N-linked (GlcNAc...) (Potential). FT DISULFID 110 187 By similarity. SQ SEQUENCE 353 AA; 39523 MW; DC56FEF259355873 CRC64; MNGTEGPFFY VPMVNTSGIV RSPYEYPQYY LVNPAAYAAL GAYMFLLILV GFPINFLTLY VTIEHKKLRT PLNYILLNLA VADLFMVFGG FTTTMYTSMH GYFVLGRLGC NIEGFFATLG GEIALWSLVV LAIERWVVVC KPISNFRFGE NHAIMGLAFT WIMAMACAAP PLVGWSRYIP EGMQCSCGID YYTRAEGFNN ESFVIYMFIC HFSIPLTIVF FCYGRLLCAV KEAAAAQQES ETTQRAEREV TRMVIMMVIA FLVCWLPYAG VAWWIFTHQG SEFGPVFMTI PAFFAKSSSI YNPMIYICLN KQFRHCMITT LCCGKNPFEE EEGASTASKT EASSVSSSSV SPA //