ID HBB_MUSGR Reviewed; 137 AA. AC Q9YGW1; DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 1. DT 05-OCT-2010, entry version 61. DE RecName: Full=Hemoglobin subunit beta; DE AltName: Full=Beta-globin; DE AltName: Full=Hemoglobin beta chain; GN Name=HBB; OS Mustelus griseus (Spotless smooth hound). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes; OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Triakidae; OC Mustelus. OX NCBI_TaxID=89020; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Miyazaki G., Yoshimatu K., Kawasaki Y., Suzuki T.; RT "Hemoglobin beta chain of spotless smooth hound (Mustelus griseus)."; RL Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases. RN [2] RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 2-137, AND METAL BINDING AT RP HIS-54 AND HIS-83. RX PubMed=11243818; DOI=10.1006/jmbi.2000.4446; RA Naoi Y., Chong K.T., Yoshimatsu K., Miyazaki G., Tame J.R., Park S.Y., RA Adachi S., Morimoto H.; RT "The functional similarity and structural diversity of human and RT cartilaginous fish hemoglobins."; RL J. Mol. Biol. 307:259-270(2001). CC -!- FUNCTION: Involved in oxygen transport from the lung to the CC various peripheral tissues. CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains. CC -!- TISSUE SPECIFICITY: Red blood cells. CC -!- SIMILARITY: Belongs to the globin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB023801; BAA75400.1; -; mRNA. DR PDB; 1GCV; X-ray; 2.00 A; B/D=2-137. DR PDB; 1GCW; X-ray; 2.00 A; B/D=2-136. DR PDBsum; 1GCV; -. DR PDBsum; 1GCW; -. DR ProteinModelPortal; Q9YGW1; -. DR HOVERGEN; HBG009709; -. DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0019825; F:oxygen binding; IEA:InterPro. DR GO; GO:0005344; F:oxygen transporter activity; IEA:UniProtKB-KW. DR InterPro; IPR012292; Globin. DR InterPro; IPR009050; Globin-like. DR InterPro; IPR000971; Globin_subset. DR InterPro; IPR002337; Haemoglobin_b. DR Gene3D; G3DSA:1.10.490.10; Globin_related; 1. DR PANTHER; PTHR11442:SF7; Beta_haem; 1. DR Pfam; PF00042; Globin; 1. DR SUPFAM; SSF46458; Globin_like; 1. DR PROSITE; PS01033; GLOBIN; 1. PE 1: Evidence at protein level; KW 3D-structure; Heme; Iron; Metal-binding; Oxygen transport; Transport. FT CHAIN 1 137 Hemoglobin subunit beta. FT /FTId=PRO_0000053028. FT METAL 54 54 Iron (heme distal ligand). FT METAL 83 83 Iron (heme proximal ligand). FT HELIX 6 18 FT HELIX 21 35 FT HELIX 37 42 FT TURN 43 45 FT HELIX 51 67 FT TURN 68 70 FT HELIX 72 75 FT HELIX 77 85 FT HELIX 91 93 FT HELIX 94 109 FT HELIX 110 112 FT HELIX 115 133 SQ SEQUENCE 137 AA; 16074 MW; 08F2165693645D98 CRC64; MVHWTQEERD EISKTFQGTD MKTVVTQALD RMFKVYPWTN RYFQKRTDFR SSIHAGIVVG ALQDAVKHMD DVKTLFKDLS KKHADDLHVD PGSFHLLTDC IIVELAYLRK DCFTPHIQGI WDKFFEVVID AISKQYH //