ID   O51B2_HUMAN             Reviewed;         312 AA.
AC   Q9Y5P1; Q17R53; Q96RD4;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 4.
DT   29-SEP-2021, entry version 169.
DE   RecName: Full=Olfactory receptor 51B2;
DE   AltName: Full=Odorant receptor HOR5'beta3;
DE   AltName: Full=Olfactory receptor 51B1;
GN   Name=OR51B2; Synonyms=OR51B1P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-120; PHE-134; SER-209
RP   AND ARG-312.
RX   PubMed=10220430; DOI=10.1073/pnas.96.9.5129;
RA   Bulger M., van Doorninck J.H., Saitoh N., Telling A., Farrell C.M.,
RA   Bender M.A., Felsenfeld G., Axel R., Groudine M.;
RT   "Conservation of sequence and structure flanking the mouse and human beta-
RT   globin loci: the beta-globin genes are embedded within an array of odorant
RT   receptor genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:5129-5134(1999).
RN   [2]
RP   ERRATUM OF PUBMED:10220430.
RA   Bulger M., van Doorninck J.H., Saitoh N., Telling A., Farrell C.M.,
RA   Bender M.A., Felsenfeld G., Axel R., Groudine M.;
RL   Proc. Natl. Acad. Sci. U.S.A. 96:8307-8307(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS SER-209 AND SER-283.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-283, AND VARIANTS ARG-120; PHE-134
RP   AND SER-209.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [6] {ECO:0007744|PDB:6LBG}
RP   X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 303-311 IN COMPLEX WITH FEM1C,
RP   AND UBIQUITINATION.
RX   PubMed=33398168; DOI=10.1038/s41589-020-00704-3;
RA   Chen X., Liao S., Makaros Y., Guo Q., Zhu Z., Krizelman R., Dahan K.,
RA   Tu X., Yao X., Koren I., Xu C.;
RT   "Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3
RT   ligase.";
RL   Nat. Chem. Biol. 17:254-262(2021).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- PTM: Ubiquitinated by the CRL2(FEM1A) and CRL2(FEM1C) complexes, which
CC       recognize the -Lys-Xaa-Xaa-Arg C-degron at the C-terminus, leading to
CC       its degradation. {ECO:0000269|PubMed:33398168}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51B2";
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DR   EMBL; AF137396; AAD29425.2; -; Genomic_DNA.
DR   EMBL; AC104389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC117461; AAI17462.1; -; mRNA.
DR   EMBL; AF399503; AAK94988.1; -; Genomic_DNA.
DR   RefSeq; NP_149420.4; NM_033180.4.
DR   PDB; 6LBG; X-ray; 2.51 A; A/B=303-311.
DR   PDBsum; 6LBG; -.
DR   SMR; Q9Y5P1; -.
DR   STRING; 9606.ENSP00000327540; -.
DR   GlyGen; Q9Y5P1; 1 site.
DR   iPTMnet; Q9Y5P1; -.
DR   PhosphoSitePlus; Q9Y5P1; -.
DR   BioMuta; OR51B2; -.
DR   DMDM; 296439490; -.
DR   PaxDb; Q9Y5P1; -.
DR   PeptideAtlas; Q9Y5P1; -.
DR   PRIDE; Q9Y5P1; -.
DR   ProteomicsDB; 86458; -.
DR   Antibodypedia; 78942; 44 antibodies.
DR   DNASU; 79345; -.
DR   Ensembl; ENST00000624187; ENSP00000485407; ENSG00000279012.
DR   GeneID; 79345; -.
DR   KEGG; hsa:79345; -.
DR   UCSC; uc001mao.2; human.
DR   CTD; 79345; -.
DR   GeneCards; OR51B2; -.
DR   HGNC; HGNC:14703; OR51B2.
DR   HPA; ENSG00000279012; Not detected.
DR   neXtProt; NX_Q9Y5P1; -.
DR   PharmGKB; PA32364; -.
DR   VEuPathDB; HostDB:ENSG00000279012; -.
DR   eggNOG; ENOG502TAGS; Eukaryota.
DR   GeneTree; ENSGT01040000240417; -.
DR   HOGENOM; CLU_012526_0_0_1; -.
DR   InParanoid; Q9Y5P1; -.
DR   OMA; MWPNITA; -.
DR   OrthoDB; 988616at2759; -.
DR   PhylomeDB; Q9Y5P1; -.
DR   TreeFam; TF342735; -.
DR   PathwayCommons; Q9Y5P1; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   BioGRID-ORCS; 79345; 3 hits in 616 CRISPR screens.
DR   GeneWiki; OR51B2; -.
DR   GenomeRNAi; 79345; -.
DR   Pharos; Q9Y5P1; Tdark.
DR   PRO; PR:Q9Y5P1; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9Y5P1; protein.
DR   Bgee; ENSG00000279012; Expressed in calcaneal tendon and 6 other tissues.
DR   ExpressionAtlas; Q9Y5P1; baseline and differential.
DR   Genevisible; Q9Y5P1; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Disulfide bond; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Olfaction; Receptor; Reference proteome;
KW   Sensory transduction; Transducer; Transmembrane; Transmembrane helix;
KW   Ubl conjugation.
FT   CHAIN           1..312
FT                   /note="Olfactory receptor 51B2"
FT                   /id="PRO_0000150745"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..52
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..97
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        216..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        95..187
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         120
FT                   /note="C -> R (in dbSNP:rs7952293)"
FT                   /evidence="ECO:0000269|PubMed:10220430,
FT                   ECO:0000269|PubMed:12213199"
FT                   /id="VAR_063114"
FT   VARIANT         134
FT                   /note="L -> F (in dbSNP:rs10837814)"
FT                   /evidence="ECO:0000269|PubMed:10220430,
FT                   ECO:0000269|PubMed:12213199"
FT                   /id="VAR_063115"
FT   VARIANT         209
FT                   /note="C -> S (in dbSNP:rs7937237)"
FT                   /evidence="ECO:0000269|PubMed:10220430,
FT                   ECO:0000269|PubMed:12213199, ECO:0000269|PubMed:15489334"
FT                   /id="VAR_063116"
FT   VARIANT         283
FT                   /note="P -> S (in dbSNP:rs11036815)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_057576"
FT   VARIANT         312
FT                   /note="S -> R (in dbSNP:rs11036814)"
FT                   /evidence="ECO:0000269|PubMed:10220430"
FT                   /id="VAR_063117"
SQ   SEQUENCE   312 AA;  35373 MW;  47E1BA5852C36966 CRC64;
     MWPNITAAPF LLTGFPGLEA AHHWISIPFF AVYVCILLGN GMLLYLIKHD HSLHEPMYYF
     LTMLAGTDLM VTLTTMPTVM GILWVNHREI SSVGCFLQAY FIHSLSVVES GSLLAMAYDC
     FIAIRNPLRY ASILTNTRVI ALGVGVFLRG FVSILPVILR LFSFSYCKSH VITRAFCLHQ
     EIMRLACADI TFNRLYPVIL ISLTIFLDCL IILFSYILIL NTVIGIASGE ERAKALNTCI
     SHISCVLIFY VTVMGLTFIY RFGKNVPEVV HIIMSYIYFL FPPLMNPVIY SIKTKQIQYG
     IIRLLSKHRF SS
//