ID N6MT1_HUMAN Reviewed; 214 AA. AC Q9Y5N5; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2000, sequence version 2. DT 16-DEC-2008, entry version 61. DE RecName: Full=N(6)-adenine-specific DNA methyltransferase 1; DE EC=2.1.1.-; DE AltName: Full=HemK methyltransferase family member 2; DE AltName: Full=M.HsaHemK2P; GN Name=N6AMT1; Synonyms=C21orf127, HEMK2; ORFNames=PRED28; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Reboul J., Misseri Y., Bonnerot C., Mogensen E., Lutfalla G.; RT "Identification of a novel putative eukaryotic DNA- RT methyltransferase."; RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=20289799; PubMed=10830953; DOI=10.1038/35012518; RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., RA Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., RA Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., RA Polley A., Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., RA Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., RA Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., RA Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., RA Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., RA Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., RA Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., RA Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., RA Lehrach H., Reinhardt R., Yaspo M.-L.; RT "The DNA sequence of human chromosome 21."; RL Nature 405:311-319(2000). CC -!- SIMILARITY: Belongs to the hemK family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF139682; AAD38520.1; -; mRNA. DR EMBL; AL163248; CAB90428.1; -; Genomic_DNA. DR UniGene; Hs.163846; -. DR PRIDE; Q9Y5N5; -. DR Ensembl; ENSG00000156239; Homo sapiens. DR GeneCards; GC21M029166; -. DR HGNC; HGNC:16021; N6AMT1. DR HOGENOM; Q9Y5N5; -. DR HOVERGEN; Q9Y5N5; -. DR LinkHub; Q9Y5N5; -. DR ArrayExpress; Q9Y5N5; -. DR CleanEx; HS_N6AMT1; -. DR GermOnline; ENSG00000156239; Homo sapiens. DR GO; GO:0008168; F:methyltransferase activity; IEA:InterPro. DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro. DR GO; GO:0032259; P:methylation; IEA:InterPro. DR InterPro; IPR004557; HemK_rel_arch. DR InterPro; IPR002052; N6_adenine_Mtase_CS. DR InterPro; IPR007848; Small_mtfrase. DR Pfam; PF05175; MTS; 1. DR TIGRFAMs; TIGR00537; hemK_rel_arch; 1. DR PROSITE; PS00092; N6_MTASE; 1. PE 2: Evidence at transcript level; KW Methyltransferase; Transferase. FT CHAIN 1 214 N(6)-adenine-specific DNA FT methyltransferase 1. FT /FTId=PRO_0000088049. FT CONFLICT 146 146 K -> R (in Ref. 1; AAD38520). FT CONFLICT 166 166 K -> R (in Ref. 1; AAD38520). SQ SEQUENCE 214 AA; 22901 MW; 44F19A593BA29DCC CRC64; MAGENFATPF HGHVGRGAFS DVYEPAEDTF LLLDALEAAA AELAGVEICL EVGSGSGVVS AFLASMIGPQ ALYMCTDINP EAAACTLETA RCNKVHIQPV ITDLVKGLLP RLTEKVDLLV FNPPYVVTPP QEVGSHGIEA AWAGGKNGRE VMDRFFPLVP DLLSPKGLFY LVTIKENNPE EILKIMKTKG LQGTTALSRQ AGQETLSVLK FTKS //