ID CDA2_HUMAN STANDARD; PRT; 948 AA. AC Q9Y5H9; O75287; Q9BTV3; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-SEP-2003 (Rel. 42, Last annotation update) DE Protocadherin alpha 2 precursor (PCDH-alpha2). GN PCDHA2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. (ISOFORMS 1 AND 2). RC TISSUE=Brain; RX MEDLINE=99308636; PubMed=10380929; RA Wu Q., Maniatis T.; RT "A striking organization of a large family of human neural cadherin- RT like cell adhesion genes."; RL Cell 97:779-790(1999). RN [2] RP SEQUENCE FROM N.A. (ISOFORM 2). RA Kimmerly W., Bondoc M., Cheng J., Connolly K.S., Gunning K.M., RA Kadner K., Miguel T., Miller C., Pitluck S., Pollard M., Rojeski H., RA Subramanian S., Martin C.H.; RT "Sequencing of human chromosome 5."; RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases. RN [3] RP SEQUENCE FROM N.A. (ISOFORM 3). RC TISSUE=Brain; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [4] RP SEQUENCE OF 23-32. RC TISSUE=Platelet; RX MEDLINE=22608298; PubMed=12665801; RA Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., RA Thomas G.R., Vandekerckhove J.; RT "Exploring proteomes and analyzing protein processing by mass RT spectrometric identification of sorted N-terminal peptides."; RL Nat. Biotechnol. 21:566-569(2003). CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. CC -!- SUBCELLULAR LOCATION: Type I membrane protein (By similarity). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q9Y5H9-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9Y5H9-2; Sequence=VSP_000673, VSP_000674; CC Name=3; CC IsoId=Q9Y5H9-3; Sequence=VSP_008040, VSP_008041; CC Note=No experimental confirmation available; CC -!- SIMILARITY: Contains 6 cadherin domains. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF152310; AAD43704.1; -. DR EMBL; AF152480; AAD43741.1; -. DR EMBL; AC005609; AAC34324.1; -. DR EMBL; BC003126; AAH03126.1; -. DR Genew; HGNC:8668; PCDHA2. DR MIM; 606308; -. DR MIM; 604966; -. DR InterPro; IPR002126; Cadherin. DR Pfam; PF00028; cadherin; 5. DR PRINTS; PR00205; CADHERIN. DR SMART; SM00112; CA; 6. DR PROSITE; PS00232; CADHERIN_1; 5. DR PROSITE; PS50268; CADHERIN_2; 6. KW Calcium-binding; Cell adhesion; Glycoprotein; Signal; Repeat; KW Transmembrane; Alternative splicing; Multigene family. FT SIGNAL 1 22 FT CHAIN 23 948 PROTOCADHERIN ALPHA 2. FT DOMAIN 23 697 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 698 718 POTENTIAL. FT DOMAIN 719 948 CYTOPLASMIC (POTENTIAL). FT DOMAIN 30 133 CADHERIN 1. FT DOMAIN 157 242 CADHERIN 2. FT DOMAIN 243 350 CADHERIN 3. FT DOMAIN 351 455 CADHERIN 4. FT DOMAIN 456 565 CADHERIN 5. FT DOMAIN 588 678 CADHERIN 6. FT DOMAIN 921 928 POLY-LYS. FT DOMAIN 734 892 5 X PXXP REPEATS. FT REPEAT 734 737 PXXP 1. FT REPEAT 797 800 PXXP 2. FT REPEAT 830 833 PXXP 3. FT REPEAT 871 874 PXXP 4. FT REPEAT 889 892 PXXP 5. FT CARBOHYD 257 257 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 265 265 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 362 362 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 548 548 N-LINKED (GLCNAC...) (POTENTIAL). FT VARSPLIC 797 824 PRQPNPDWRYSASLRAGMHSSVHLEEAG -> VSLLLFLAN FT SKIVLFKKFYMISTSYLDS (in isoform 2). FT /FTId=VSP_000673. FT VARSPLIC 797 808 PRQPNPDWRYSA -> IWNFNLQIQLAS (in FT isoform 3). FT /FTId=VSP_008040. FT VARSPLIC 809 948 Missing (in isoform 3). FT /FTId=VSP_008041. FT VARSPLIC 825 948 Missing (in isoform 2). FT /FTId=VSP_000674. SQ SEQUENCE 948 AA; 102062 MW; 8D2E9644982AE59E CRC64; MASSIRRGRG AWTRLLSLLL LAAWEVGSGQ LRYSVPEEAK HGTFVGRIAQ DLGLELEELV PRLFRVASKR HGDLLEVNLQ NGILFVNSRI DREELCGRSA ECSIHVEVIV DRPLQVFHVE VEVKDINDNP PIFPMTVKTI RFPESRLLDS RFPLEGASDA DIGVNALLSY KLSSSEFFFL DIQANDELSE SLSLVLGKSL DREETAEVNL LLVATDGGKP ELTGTVQILI KVLDVNDNEP TFAQSVYKVK LLENTANGTL VVKLNASDAD EGPNSEIVYS LGSDVSSTIQ TKFTIDPISG EIRTKGKLDY EEAKSYEIQV TATDKGTPSM SGHCKISLKL VDINDNTPEV SITSLSLPIS ENASLGTVIA LITVSDRDSG TNGHVTCSLT PHVPFKLVST FKNYYSLVLD SALDRESVSA YELVVTARDG GSPSLWATTS VSIEVADVND NAPAFAQPEY TVFVKENNPP GCHIFTVSAW DADAQENALV SYSLVERRVG ERALSSYVSV HAESGKVYAL QPLDHEEVEL LQFQVSARDA GVPPLGSNVT LQVFVLDEND NAPALLAPRA GTAAGAVSEL VPWSVGAGHV VAKVRAVDAD SGYNAWLSYE LQLGTGSARI PFRVGLYTGE ISTTRALDEA DSPRHRLLVL VKDHGEPALT ATATVLVSLV ESGQAPKASS RAWVGAAGSE ATLVDVNVYL IIAICAVSSL LVLTVLLYTA LRCSVPPTEG ARAPGKPTLV CSSAVGSWSY SQQRRQRVCS GEDPPKTDLM AFSPSLSQGP DSAEEKQLSE SEYVGKPRQP NPDWRYSASL RAGMHSSVHL EEAGILRAGP GGPDQQWPTV SSATPEPEAG EVSPPVGAGV NSNSWTFKYG PGNPKQSGPG ELPDKFIIPG SPAIISIRQE PTNSQIDKSD FITFGKKEET KKKKKKKKGN KTQEKKEKGN STTDNSDQ //