ID   YTHD2_HUMAN             Reviewed;         579 AA.
AC   Q9Y5A9; Q5VSZ9; Q8TDH0; Q9BUJ5;
DT   12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2004, sequence version 2.
DT   26-FEB-2008, entry version 58.
DE   YTH domain family protein 2 (High-glucose-regulated protein 8) (CLL-
DE   associated antigen KW-14) (Renal carcinoma antigen NY-REN-2).
GN   Name=YTHDF2; Synonyms=HGRG8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND IDENTIFICATION AS A RENAL
RP   CANCER ANTIGEN.
RC   TISSUE=Renal cell carcinoma;
RX   MEDLINE=99438124; PubMed=10508479;
RX   DOI=10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5;
RA   Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H.,
RA   Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T.,
RA   Old L.J.;
RT   "Antigens recognized by autologous antibody in patients with renal-
RT   cell carcinoma.";
RL   Int. J. Cancer 83:456-464(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Roberts T.P., Wright A., Wahab N.A., Weston B.S., Mason R.M.;
RT   "Gene which is selectively expressed in hyperglycaemia.";
RL   Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA   Krackhardt A.M., Witzens M., Harig S., Hodi F.S., Zauls A.J.,
RA   Chessia M., Barrett P., Gribben J.G.;
RT   "Identification of novel tumor antigens in CLL by SEREX: assessment of
RT   their potential as targets for immunotherapeutic approaches.";
RL   Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA   Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA   Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA   Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA   Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA   Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA   Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA   Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA   Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA   Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA   Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA   Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA   Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA   Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-37, AND MASS
RP   SPECTROMETRY.
RX   PubMed=15592455; DOI=10.1038/nbt1046;
RA   Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,
RA   Zha X.-M., Polakiewicz R.D., Comb M.J.;
RT   "Immunoaffinity profiling of tyrosine phosphorylation in cancer
RT   cells.";
RL   Nat. Biotechnol. 23:94-101(2005).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Epithelium;
RX   PubMed=16964243; DOI=10.1038/nbt1240;
RA   Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
RT   "A probability-based approach for high-throughput protein
RT   phosphorylation analysis and site localization.";
RL   Nat. Biotechnol. 24:1285-1292(2006).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9Y5A9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9Y5A9-2; Sequence=VSP_009297;
CC         Note=May be due to intron retention. No experimental
CC         confirmation available;
CC   -!- SIMILARITY: Contains 1 YTH domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD42861.1; Type=Frameshift; Positions=565;
CC       Sequence=AAF08813.1; Type=Frameshift; Positions=565;
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DR   EMBL; AF155095; AAD42861.1; ALT_FRAME; mRNA.
DR   EMBL; AF192968; AAF08813.1; ALT_FRAME; mRNA.
DR   EMBL; AF432214; AAL99921.1; ALT_SEQ; mRNA.
DR   EMBL; AL645729; CAH72429.1; -; Genomic_DNA.
DR   EMBL; AL356786; CAH72429.1; JOINED; Genomic_DNA.
DR   EMBL; AL356786; CAI21658.1; -; Genomic_DNA.
DR   EMBL; AL645729; CAI21658.1; JOINED; Genomic_DNA.
DR   EMBL; BC002559; AAH02559.1; -; mRNA.
DR   RefSeq; NP_057342.2; -.
DR   UniGene; Hs.532286; -.
DR   PhosphoSite; Q9Y5A9; -.
DR   Ensembl; ENSG00000198492; Homo sapiens.
DR   GeneID; 51441; -.
DR   KEGG; hsa:51441; -.
DR   H-InvDB; HIX0000341; -.
DR   H-InvDB; HIX0015995; -.
DR   HGNC; HGNC:31675; YTHDF2.
DR   MIM; 610640; gene.
DR   PharmGKB; PA134964518; -.
DR   LinkHub; Q9Y5A9; -.
DR   ArrayExpress; Q9Y5A9; -.
DR   CleanEx; HS_YTHDF2; -.
DR   GermOnline; ENSG00000198492; Homo sapiens.
DR   GO; GO:0006959; P:humoral immune response; TAS:ProtInc.
DR   InterPro; IPR007275; YTH.
DR   PANTHER; PTHR12357; YTH; 1.
DR   Pfam; PF04146; YTH; 1.
DR   PROSITE; PS50882; YTH; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Phosphoprotein.
FT   CHAIN         1    579       YTH domain family protein 2.
FT                                /FTId=PRO_0000223075.
FT   DOMAIN      410    544       YTH.
FT   MOD_RES      37     37       Phosphotyrosine.
FT   MOD_RES      39     39       Phosphoserine.
FT   VAR_SEQ       1     50       Missing (in isoform 2).
FT                                /FTId=VSP_009297.
SQ   SEQUENCE   579 AA;  62334 MW;  BF3959B5561A464E CRC64;
     MSASSLLEQR PKGQGNKVQN GSVHQKDGLN DDDFEPYLSP QARPNNAYTA MSDSYLPSYY
     SPSIGFSYSL GEAAWSTGGD TAMPYLTSYG QLSNGEPHFL PDAMFGQPGA LGSTPFLGQH
     GFNFFPSGID FSAWGNNSSQ GQSTQSSGYS SNYAYAPSSL GGAMIDGQSA FANETLNKAP
     GMNTIDQGMA ALKLGSTEVA SNVPKVVGSA VGSGSITSNI VASNSLPPAT IAPPKPASWA
     DIASKPAKQQ PKLKTKNGIA GSSLPPPPIK HNMDIGTWDN KGPVAKAPSQ ALVQNIGQPT
     QGSPQPVGQQ ANNSPPVAQA SVGQQTQPLP PPPPQPAQLS VQQQAAQPTR WVAPRNRGSG
     FGHNGVDGNG VGQSQAGSGS TPSEPHPVLE KLRSINNYNP KDFDWNLKHG RVFIIKSYSE
     DDIHRSIKYN IWCSTEHGNK RLDAAYRSMN GKGPVYLLFS VNGSGHFCGV AEMKSAVDYN
     TCAGVWSQDK WKGRFDVRWI FVKDVPNSQL RHIRLENNEN KPVTNSRDTQ EVPLEKAKQV
     LKIIASYKHT TSIFDDFSHY EKRQEEEESV KKERQGRGK
//