ID   YTHD2_HUMAN    STANDARD;      PRT;   579 AA.
AC   Q9Y5A9; Q8TDH0; Q9BUJ5;
DT   28-FEB-2003 (Rel. 41, Created)
DT   29-MAR-2004 (Rel. 43, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   YTH domain protein 2 (High-glucose-regulated protein 8) (NY-REN-2
DE   antigen) (CLL-associated antigen KW-14).
GN   Name=YTHDF2; Synonyms=HGRG8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE (ISOFORM 1).
RC   TISSUE=Renal cell carcinoma;
RX   MEDLINE=99438124; PubMed=10508479;
RA   Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H.,
RA   Jongeneel C.V., Gure A.O., Jager D., Jager E., Knuth A., Chen Y.-T.,
RA   Old L.J.;
RT   "Antigens recognized by autologous antibody in patients with renal-
RT   cell carcinoma.";
RL   Int. J. Cancer 83:456-464(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE (ISOFORM 1).
RA   Roberts T.P., Wright A., Wahab N.A., Weston B.S., Mason R.M.;
RT   "Gene which is selectively expressed in hyperglycaemia.";
RL   Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE (ISOFORM 2).
RA   Krackhardt A.M., Witzens M., Harig S., Hodi F.S., Zauls A.J.,
RA   Chessia M., Barrett P., Gribben J.G.;
RT   "Identification of novel tumor antigens in CLL by SEREX: assessment of
RT   their potential as targets for immunotherapeutic approaches.";
RL   Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Placenta;
RX   MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9Y5A9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9Y5A9-2; Sequence=VSP_009297;
CC         Note=May be due to intron retention. No experimental
CC         confirmation available;
CC   -!- SIMILARITY: Contains 1 YTH domain.
CC   -!- CAUTION: Ref.1 and Ref.2 sequences differ from that shown due to a
CC       frameshift in position 565.
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DR   EMBL; AF155095; AAD42861.1; ALT_FRAME.
DR   EMBL; AF192968; AAF08813.1; ALT_FRAME.
DR   EMBL; AF432214; AAL99921.1; ALT_SEQ.
DR   EMBL; BC002559; AAH02559.1; -.
DR   Genew; HGNC:31675; YTHDF2.
DR   GO; GO:0006959; P:humoral immune response; TAS.
DR   InterPro; IPR007275; YTH.
DR   Pfam; PF04146; YTH; 1.
DR   PROSITE; PS50882; YTH; 1.
KW   Alternative splicing.
FT   DOMAIN      410    544       YTH.
FT   VARSPLIC      1     50       Missing (in isoform 2).
FT                                /FTId=VSP_009297.
SQ   SEQUENCE   579 AA;  62334 MW;  BF3959B5561A464E CRC64;
     MSASSLLEQR PKGQGNKVQN GSVHQKDGLN DDDFEPYLSP QARPNNAYTA MSDSYLPSYY
     SPSIGFSYSL GEAAWSTGGD TAMPYLTSYG QLSNGEPHFL PDAMFGQPGA LGSTPFLGQH
     GFNFFPSGID FSAWGNNSSQ GQSTQSSGYS SNYAYAPSSL GGAMIDGQSA FANETLNKAP
     GMNTIDQGMA ALKLGSTEVA SNVPKVVGSA VGSGSITSNI VASNSLPPAT IAPPKPASWA
     DIASKPAKQQ PKLKTKNGIA GSSLPPPPIK HNMDIGTWDN KGPVAKAPSQ ALVQNIGQPT
     QGSPQPVGQQ ANNSPPVAQA SVGQQTQPLP PPPPQPAQLS VQQQAAQPTR WVAPRNRGSG
     FGHNGVDGNG VGQSQAGSGS TPSEPHPVLE KLRSINNYNP KDFDWNLKHG RVFIIKSYSE
     DDIHRSIKYN IWCSTEHGNK RLDAAYRSMN GKGPVYLLFS VNGSGHFCGV AEMKSAVDYN
     TCAGVWSQDK WKGRFDVRWI FVKDVPNSQL RHIRLENNEN KPVTNSRDTQ EVPLEKAKQV
     LKIIASYKHT TSIFDDFSHY EKRQEEEESV KKERQGRGK
//