ID   OR1A2_HUMAN             Reviewed;         309 AA.
AC   Q9Y585; Q3KPH3; Q6IFM0; Q6NTD8; Q96R86;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   12-OCT-2022, entry version 166.
DE   RecName: Full=Olfactory receptor 1A2;
DE   AltName: Full=Olfactory receptor 17-6;
DE            Short=OR17-6;
DE   AltName: Full=Olfactory receptor OR17-10;
GN   Name=OR1A2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10673334; DOI=10.1006/geno.1999.6030;
RA   Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A.,
RA   Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.;
RT   "Sequence, structure, and evolution of a complete human olfactory receptor
RT   gene cluster.";
RL   Genomics 63:227-245(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS CYS-256; CYS-260 AND
RP   CYS-293.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1A2";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF155225; AAD39545.1; -; Genomic_DNA.
DR   EMBL; BC069092; AAH69092.1; -; mRNA.
DR   EMBL; BC106733; AAI06734.1; -; mRNA.
DR   EMBL; BC106734; AAI06735.1; -; mRNA.
DR   EMBL; AF399556; AAK95041.1; -; Genomic_DNA.
DR   EMBL; BK004242; DAA04640.1; -; Genomic_DNA.
DR   CCDS; CCDS11021.1; -.
DR   RefSeq; NP_036484.1; NM_012352.2.
DR   AlphaFoldDB; Q9Y585; -.
DR   SMR; Q9Y585; -.
DR   BioGRID; 117602; 11.
DR   STRING; 9606.ENSP00000371377; -.
DR   GlyGen; Q9Y585; 1 site.
DR   iPTMnet; Q9Y585; -.
DR   PhosphoSitePlus; Q9Y585; -.
DR   BioMuta; OR1A2; -.
DR   DMDM; 9297027; -.
DR   MassIVE; Q9Y585; -.
DR   PaxDb; Q9Y585; -.
DR   PeptideAtlas; Q9Y585; -.
DR   PRIDE; Q9Y585; -.
DR   Antibodypedia; 62121; 31 antibodies from 15 providers.
DR   DNASU; 26189; -.
DR   Ensembl; ENST00000381951.1; ENSP00000371377.1; ENSG00000172150.4.
DR   GeneID; 26189; -.
DR   KEGG; hsa:26189; -.
DR   MANE-Select; ENST00000381951.1; ENSP00000371377.1; NM_012352.3; NP_036484.1.
DR   UCSC; uc002fvd.1; human.
DR   CTD; 26189; -.
DR   GeneCards; OR1A2; -.
DR   HGNC; HGNC:8180; OR1A2.
DR   HPA; ENSG00000172150; Not detected.
DR   MIM; 618047; gene.
DR   neXtProt; NX_Q9Y585; -.
DR   OpenTargets; ENSG00000172150; -.
DR   PharmGKB; PA32052; -.
DR   VEuPathDB; HostDB:ENSG00000172150; -.
DR   eggNOG; ENOG502TF5D; Eukaryota.
DR   GeneTree; ENSGT00900000141057; -.
DR   HOGENOM; CLU_012526_5_5_1; -.
DR   InParanoid; Q9Y585; -.
DR   OMA; GTTMGMY; -.
DR   OrthoDB; 879962at2759; -.
DR   PhylomeDB; Q9Y585; -.
DR   TreeFam; TF337210; -.
DR   PathwayCommons; Q9Y585; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 26189; 3 hits in 665 CRISPR screens.
DR   GeneWiki; OR1A2; -.
DR   GenomeRNAi; 26189; -.
DR   Pharos; Q9Y585; Tdark.
DR   PRO; PR:Q9Y585; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q9Y585; protein.
DR   ExpressionAtlas; Q9Y585; differential.
DR   Genevisible; Q9Y585; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0032467; P:positive regulation of cytokinesis; IMP:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..309
FT                   /note="Olfactory receptor 1A2"
FT                   /id="PRO_0000150415"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..270
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..290
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        291..309
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         244
FT                   /note="L -> F (in dbSNP:rs56058341)"
FT                   /id="VAR_062007"
FT   VARIANT         256
FT                   /note="G -> C (in dbSNP:rs2241091)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_022047"
FT   VARIANT         260
FT                   /note="R -> C (in dbSNP:rs2469791)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_034162"
FT   VARIANT         293
FT                   /note="W -> C (in dbSNP:rs12150427)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_034163"
SQ   SEQUENCE   309 AA;  34396 MW;  0BB9B26EB8D51B90 CRC64;
     MKKENQSFNL DFILLGVTSQ QEQNNVFFVI FLCIYPITLT GNLLIILAIC ADIRLHNPMY
     FLLANLSLVD IIFSSVTIPK VLANHLLGSK FISFGGCLMQ MYFMIALAKA DSYTLAAMAY
     DRAVAISCPL HYTTIMSPRS CILLIAGSWV IGNTSALPHT LLTASLSFCG NQEVANFYCD
     IMPLLKLSCS DVHFNVKMMY LGVGVFSLPL LCIIVSYVQV FSTVFQVPST KSLFKAFCTC
     GSHLTVVFLY YGTTMGMYFR PLTSYSPKDA VITVMYVAVT PALNPFIYSL RNWDMKAALQ
     KLFSKRISS
//