ID ACOT9_HUMAN Reviewed; 439 AA. AC Q9Y305; B3KNC9; DT 08-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 03-MAR-2009, sequence version 2. DT 14-APR-2009, entry version 54. DE RecName: Full=Acyl-coenzyme A thioesterase 9, mitochondrial; DE Short=Acyl-CoA thioesterase 9; DE EC=3.1.2.-; DE AltName: Full=Acyl-CoA thioester hydrolase 9; DE Flags: Precursor; GN Name=ACOT9; ORFNames=CGI-16; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RX MEDLINE=20272150; PubMed=10810093; DOI=10.1101/gr.10.5.703; RA Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.; RT "Identification of novel human genes evolutionarily conserved in RT Caenorhabditis elegans by comparative proteomics."; RL Genome Res. 10:703-713(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RC TISSUE=Placenta; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY. RA Colinge J., Superti-Furga G., Bennett K.L.; RL Submitted (OCT-2008) to UniProtKB. CC -!- FUNCTION: Acyl-CoA thioesterases are a group of enzymes that CC catalyze the hydrolysis of acyl-CoAs to the free fatty acid and CC coenzyme A (CoASH), providing the potential to regulate CC intracellular levels of acyl-CoAs, free fatty acids and CoASH. CC Active on long chain acyl-CoAs. CC -!- SUBCELLULAR LOCATION: Mitochondrion (By similarity). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q9Y305-1; Sequence=Displayed; CC Note=No experimental confirmation available; CC Name=2; CC IsoId=Q9Y305-2; Sequence=VSP_036419; CC Note=No experimental confirmation available; CC Name=3; CC IsoId=Q9Y305-3; Sequence=VSP_036420; CC Note=No experimental confirmation available; CC -!- SIMILARITY: Belongs to the acyl coenzyme A hydrolase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF132950; AAD27725.1; -; mRNA. DR EMBL; AK024337; BAG51291.1; -; mRNA. DR IPI; IPI00220710; -. DR IPI; IPI00748985; -. DR IPI; IPI00921986; -. DR RefSeq; NP_001028755.2; -. DR UniGene; Hs.298885; -. DR PRIDE; Q9Y305; -. DR Ensembl; ENSG00000123130; Homo sapiens. DR GeneID; 23597; -. DR GeneCards; GC0XM023629; -. DR HGNC; HGNC:17152; ACOT9. DR PharmGKB; PA142672656; -. DR HOGENOM; Q9Y305; -. DR HOVERGEN; Q9Y305; -. DR ArrayExpress; Q9Y305; -. DR Bgee; Q9Y305; -. DR CleanEx; HS_ACOT9; -. DR GermOnline; ENSG00000123130; Homo sapiens. DR GO; GO:0005739; C:mitochondrion; ISS:HGNC. DR GO; GO:0003986; F:acetyl-CoA hydrolase activity; ISS:HGNC. DR GO; GO:0004091; F:carboxylesterase activity; IEA:UniProtKB-KW. DR GO; GO:0005515; F:protein binding; ISS:HGNC. DR GO; GO:0006637; P:acyl-CoA metabolic process; ISS:HGNC. PE 1: Evidence at protein level; KW Alternative splicing; Hydrolase; Mitochondrion; Serine esterase; KW Transit peptide. FT TRANSIT 1 21 Mitochondrion (By similarity). FT CHAIN 22 439 Acyl-coenzyme A thioesterase 9, FT mitochondrial. FT /FTId=PRO_0000053812. FT VAR_SEQ 1 60 Missing (in isoform 3). FT /FTId=VSP_036420. FT VAR_SEQ 5 39 ALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHE -> PC FT (in isoform 2). FT /FTId=VSP_036419. FT CONFLICT 188 188 L -> S (in Ref. 2; BAG51291). SQ SEQUENCE 439 AA; 49902 MW; 1CE2158D4F83D4D6 CRC64; MRRAALRLCA LGKGQLTPGR GLTQGPQNPK KQGIFHIHEV RDKLREIVGA STNWRDHVKA MEERKLLHSF LAKSQDGLPP RRMKDSYIEV LLPLGSEPEL REKYLTVQNT VRFGRILEDL DSLGVLICYM HNKIHSAKMS PLSIVTALVD KIDMCKKSLS PEQDIKFSGH VSWVGKTSME VKMQMFQLHG DEFCPVLDAT FVMVARDSEN KGPAFVNPLI PESPEEEELF RQGELNKGRR IAFSSTSLLK MAPSAEERTT IHEMFLSTLD PKTISFRSRV LPSNAVWMEN SKLKSLEICH PQERNIFNRI FGGFLMRKAY ELAWATACSF GGSRPFVVAV DDIMFQKPVE VGSLLFLSSQ VCFTQNNYIQ VRVHSEVASL QEKQHTTTNV FHFTFMSEKE VPLVFPKTYG ESMLYLDGQR HFNSMSGPAT LRKDYLVEP //