ID ACOT9_HUMAN Reviewed; 406 AA. AC Q9Y305; DT 08-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1999, sequence version 1. DT 10-JUL-2007, entry version 39. DE Acyl-coenzyme A thioesterase 9 (EC 3.1.2.-) (Acyl-CoA thioesterase 9) DE (Acyl-CoA thioester hydrolase 9). GN Name=ACOT9; ORFNames=CGI-16; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX MEDLINE=20272150; PubMed=10810093; DOI=10.1101/gr.10.5.703; RA Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.; RT "Identification of novel human genes evolutionarily conserved in RT Caenorhabditis elegans by comparative proteomics."; RL Genome Res. 10:703-713(2000). CC -!- FUNCTION: Acyl-CoA thioesterases are a group of enzymes that CC catalyze the hydrolysis of acyl-CoAs to the free fatty acid and CC coenzyme A (CoASH), providing the potential to regulate CC intracellular levels of acyl-CoAs, free fatty acids and CoASH. CC Active on long chain acyl-CoAs. CC -!- SIMILARITY: Belongs to the acyl coenzyme A hydrolase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF132950; AAD27725.1; -; mRNA. DR UniGene; Hs.298885; -. DR Ensembl; ENSG00000123130; Homo sapiens. DR HGNC; HGNC:17152; ACOT9. DR PharmGKB; PA142672656; -. DR ArrayExpress; Q9Y305; -. DR GermOnline; ENSG00000123130; Homo sapiens. DR RZPD-ProtExp; IOH12159; -. DR RZPD-ProtExp; T2410; -. DR GO; GO:0005739; C:mitochondrion; ISS:HGNC. DR GO; GO:0003986; F:acetyl-CoA hydrolase activity; ISS:HGNC. DR GO; GO:0005515; F:protein binding; ISS:HGNC. DR GO; GO:0006637; P:acyl-CoA metabolic process; ISS:HGNC. KW Hydrolase; Serine esterase. FT CHAIN 1 406 Acyl-coenzyme A thioesterase 9. FT /FTId=PRO_0000053812. SQ SEQUENCE 406 AA; 46355 MW; 99ADE404D472CEEB CRC64; MRRAPCVRDK LREIVGASTN WRDHVKAMEE RKLLHSFLAK SQDGLPPRRM KDSYIEVLLP LGSEPELREK YLTVQNTVRF GRILEDLDSL GVLICYMHNK IHSAKMSPLS IVTALVDKID MCKKSLSPEQ DIKFSGHVSW VGKTSMEVKM QMFQLHGDEF CPVLDATFVM VARDSENKGP AFVNPLIPES PEEEELFRQG ELNKGRRIAF SSTSLLKMAP SAEERTTIHE MFLSTLDPKT ISFRSRVLPS NAVWMENSKL KSLEICHPQE RNIFNRIFGG FLMRKAYELA WATACSFGGS RPFVVAVDDI MFQKPVEVGS LLFLSSQVCF TQNNYIQVRV HSEVASLQEK QHTTTNVFHF TFMSEKEVPL VFPKTYGESM LYLDGQRHFN SMSGPATLRK DYLVEP //