ID   RT17_HUMAN              Reviewed;         130 AA.
AC   Q9Y2R5; Q86X15;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   10-FEB-2021, entry version 175.
DE   RecName: Full=28S ribosomal protein S17, mitochondrial;
DE            Short=MRP-S17;
DE            Short=S17mt;
DE   AltName: Full=Mitochondrial small ribosomal subunit protein uS17m {ECO:0000303|PubMed:25838379};
DE   Flags: Precursor;
GN   Name=MRPS17; Synonyms=RPMS17; ORFNames=HSPC011;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Umbilical cord blood;
RX   PubMed=9653160; DOI=10.1073/pnas.95.14.8175;
RA   Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H.,
RA   He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H.,
RA   Wang Y.-X., Chen S.-J., Chen Z.;
RT   "Identification of genes expressed in human CD34(+) hematopoietic
RT   stem/progenitor cells by expressed sequence tags and efficient full-length
RT   cDNA cloning.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11402041; DOI=10.1074/jbc.m103236200;
RA   Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA   Watanabe K.;
RT   "Proteomic analysis of the mammalian mitochondrial ribosome. Identification
RT   of protein components in the 28S small subunit.";
RL   J. Biol. Chem. 276:33181-33195(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=11279123; DOI=10.1074/jbc.m100727200;
RA   Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.;
RT   "The small subunit of the mammalian mitochondrial ribosome: identification
RT   of the full complement of ribosomal proteins present.";
RL   J. Biol. Chem. 276:19363-19374(2001).
RN   [5] {ECO:0000244|PDB:3J9M}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS), SUBCELLULAR LOCATION,
RP   AND SUBUNIT.
RX   PubMed=25838379; DOI=10.1126/science.aaa1193;
RA   Amunts A., Brown A., Toots J., Scheres S.H., Ramakrishnan V.;
RT   "Ribosome. The structure of the human mitochondrial ribosome.";
RL   Science 348:95-98(2015).
CC   -!- SUBUNIT: Component of the mitochondrial small ribosomal subunit (mt-
CC       SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small
CC       (28S) and a large (39S) subunit. The 28S small subunit contains a 12S
CC       ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large
CC       subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial
CC       valine transfer RNA (mt-tRNA(Val)), which plays an integral structural
CC       role, and 52 different proteins. {ECO:0000269|PubMed:25838379}.
CC   -!- INTERACTION:
CC       Q9Y2R5; P28799: GRN; NbExp=3; IntAct=EBI-1046443, EBI-747754;
CC       Q9Y2R5; O76024: WFS1; NbExp=3; IntAct=EBI-1046443, EBI-720609;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uS17 family.
CC       {ECO:0000305}.
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DR   EMBL; AF077035; AAD27768.1; -; mRNA.
DR   EMBL; AB049950; BAB41003.1; -; mRNA.
DR   EMBL; BC047445; AAH47445.2; -; mRNA.
DR   EMBL; BC054031; AAH54031.1; -; mRNA.
DR   CCDS; CCDS5520.1; -.
DR   RefSeq; NP_057053.1; NM_015969.2.
DR   PDB; 3J9M; EM; 3.50 A; AN=1-130.
DR   PDB; 6NU2; EM; 3.90 A; AN=5-111.
DR   PDB; 6NU3; EM; 4.40 A; AN=1-130.
DR   PDB; 6RW4; EM; 2.97 A; N=1-130.
DR   PDB; 6RW5; EM; 3.14 A; N=1-130.
DR   PDB; 6VLZ; EM; 2.97 A; AN=1-130.
DR   PDB; 6VMI; EM; 2.96 A; AN=1-130.
DR   PDB; 6ZS9; EM; 4.00 A; AN=1-130.
DR   PDB; 6ZSA; EM; 4.00 A; AN=1-130.
DR   PDB; 6ZSB; EM; 4.50 A; AN=1-130.
DR   PDB; 6ZSC; EM; 3.50 A; AN=1-130.
DR   PDB; 6ZSD; EM; 3.70 A; AN=1-130.
DR   PDB; 6ZSE; EM; 5.00 A; AN=1-130.
DR   PDB; 6ZSG; EM; 4.00 A; AN=1-130.
DR   PDBsum; 3J9M; -.
DR   PDBsum; 6NU2; -.
DR   PDBsum; 6NU3; -.
DR   PDBsum; 6RW4; -.
DR   PDBsum; 6RW5; -.
DR   PDBsum; 6VLZ; -.
DR   PDBsum; 6VMI; -.
DR   PDBsum; 6ZS9; -.
DR   PDBsum; 6ZSA; -.
DR   PDBsum; 6ZSB; -.
DR   PDBsum; 6ZSC; -.
DR   PDBsum; 6ZSD; -.
DR   PDBsum; 6ZSE; -.
DR   PDBsum; 6ZSG; -.
DR   SMR; Q9Y2R5; -.
DR   BioGRID; 119506; 42.
DR   ComplexPortal; CPX-5225; 28S mitochondrial small ribosomal subunit.
DR   CORUM; Q9Y2R5; -.
DR   IntAct; Q9Y2R5; 22.
DR   MINT; Q9Y2R5; -.
DR   STRING; 9606.ENSP00000285298; -.
DR   iPTMnet; Q9Y2R5; -.
DR   PhosphoSitePlus; Q9Y2R5; -.
DR   BioMuta; MRPS17; -.
DR   DMDM; 13633951; -.
DR   EPD; Q9Y2R5; -.
DR   jPOST; Q9Y2R5; -.
DR   MassIVE; Q9Y2R5; -.
DR   MaxQB; Q9Y2R5; -.
DR   PaxDb; Q9Y2R5; -.
DR   PeptideAtlas; Q9Y2R5; -.
DR   PRIDE; Q9Y2R5; -.
DR   ProteomicsDB; 85880; -.
DR   TopDownProteomics; Q9Y2R5; -.
DR   Antibodypedia; 66312; 55 antibodies.
DR   Ensembl; ENST00000285298; ENSP00000285298; ENSG00000239789.
DR   GeneID; 51373; -.
DR   KEGG; hsa:51373; -.
DR   UCSC; uc003trd.4; human.
DR   CTD; 51373; -.
DR   DisGeNET; 51373; -.
DR   GeneCards; MRPS17; -.
DR   HGNC; HGNC:14047; MRPS17.
DR   HPA; ENSG00000239789; Low tissue specificity.
DR   MIM; 611980; gene.
DR   neXtProt; NX_Q9Y2R5; -.
DR   OpenTargets; ENSG00000239789; -.
DR   PharmGKB; PA31002; -.
DR   VEuPathDB; HostDB:ENSG00000239789.5; -.
DR   eggNOG; KOG3447; Eukaryota.
DR   GeneTree; ENSGT00530000064130; -.
DR   InParanoid; Q9Y2R5; -.
DR   OrthoDB; 1515865at2759; -.
DR   PhylomeDB; Q9Y2R5; -.
DR   TreeFam; TF326484; -.
DR   PathwayCommons; Q9Y2R5; -.
DR   Reactome; R-HSA-5368286; Mitochondrial translation initiation.
DR   Reactome; R-HSA-5389840; Mitochondrial translation elongation.
DR   Reactome; R-HSA-5419276; Mitochondrial translation termination.
DR   SIGNOR; Q9Y2R5; -.
DR   BioGRID-ORCS; 51373; 118 hits in 882 CRISPR screens.
DR   ChiTaRS; MRPS17; human.
DR   GeneWiki; MRPS17; -.
DR   GenomeRNAi; 51373; -.
DR   Pharos; Q9Y2R5; Tbio.
DR   PRO; PR:Q9Y2R5; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q9Y2R5; protein.
DR   Bgee; ENSG00000239789; Expressed in liver and 118 other tissues.
DR   ExpressionAtlas; Q9Y2R5; baseline and differential.
DR   Genevisible; Q9Y2R5; HS.
DR   GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR   GO; GO:0005763; C:mitochondrial small ribosomal subunit; IDA:UniProtKB.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; HDA:UniProtKB.
DR   GO; GO:0032543; P:mitochondrial translation; HDA:UniProtKB.
DR   GO; GO:0070125; P:mitochondrial translational elongation; TAS:Reactome.
DR   GO; GO:0070126; P:mitochondrial translational termination; TAS:Reactome.
DR   GO; GO:0006412; P:translation; NAS:UniProtKB.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR000266; Ribosomal_S17/S11.
DR   InterPro; IPR039193; S17mt.
DR   PANTHER; PTHR24088; PTHR24088; 1.
DR   Pfam; PF00366; Ribosomal_S17; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Mitochondrion; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein; RNA-binding; rRNA-binding; Transit peptide.
FT   TRANSIT         1..20
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..130
FT                   /note="28S ribosomal protein S17, mitochondrial"
FT                   /id="PRO_0000030623"
SQ   SEQUENCE   130 AA;  14502 MW;  5346917E78F7C6C3 CRC64;
     MSVVRSSVHA RWIVGKVIGT KMQKTAKVRV TRLVLDPYLL KYFNKRKTYF AHDALQQCTV
     GDIVLLRALP VPRAKHVKHE LAEIVFKVGK VIDPVTGKPC AGTTYLESPL SSETTQLSKN
     LEELNISSAQ
//