ID B3GN3_HUMAN STANDARD; PRT; 372 AA. AC Q9Y2A9; Q6NWU9; Q6NXU9; Q8WWR6; Q9C0J2; DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1999, sequence version 1. DT 07-FEB-2006, entry version 40. DE UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 DE (EC 2.4.1.-) (Beta3Gn-T3) (BGnT-3) (Core 1 extending beta-1,3-N- DE acetylglucosaminyltransferase) (Core1-beta3GlcNAcT) (Beta-1,3- DE galactosyltransferase 8) (Beta-1,3-GalTase 8) (Beta3Gal-T8) (b3Gal-T8) DE (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase DE 8) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8) (Beta-3-Gx- DE T8). GN Name=B3GNT3; Synonyms=B3GALT8, TMEM3; ORFNames=UNQ637/PRO1266; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=99173880; PubMed=10072769; DOI=10.1016/S0378-1119(99)00004-9; RA Yokoyama-Kobayashi M., Yamaguchi T., Sekine S., Kato S.; RT "Selection of cDNAs encoding putative type II membrane proteins on the RT cell surface from a human full-length cDNA bank."; RL Gene 228:161-167(1999). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=21332592; PubMed=11439191; DOI=10.1016/S0092-8674(01)00394-4; RA Yeh J.-C., Hiraoka N., Petryniak B., Nakayama J., Ellies L.G., RA Rabuka D., Hindsgaul O., Marth J.D., Lowe J.B., Fakuda M.; RT "Novel sulfated lymphocyte homing receptors and their control by a RT Core1 extension beta 1,3-N-acetylglucosaminyltransferase."; RL Cell 105:957-969(2001). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-328, CATALYTIC ACTIVITY, RP FUNCTION, AND TISSUE SPECIFICITY. RC TISSUE=Gastric mucosa; RX MEDLINE=21264825; PubMed=11042166; DOI=10.1074/jbc.M004800200; RA Shiraishi N., Natsume A., Togayachi A., Endo T., Akashima T., RA Yamada Y., Imai N., Nakagawa S., Koizumi S., Sekine S., Narimatsu H., RA Sasaki K.; RT "Identification and characterization of three novel beta 1,3-N- RT acetylglucosaminyltransferases structurally related to the beta 1,3- RT galactosyltransferase family."; RL J. Biol. Chem. 276:3498-3507(2001). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Jensen M.A., Bennett E.P.; RT "Cloning of a new member of the beta 1,3 galactosyltransferase family, RT b1,3Gal-T6."; RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Bennett E.P.; RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., RA Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale RT effort to identify novel human secreted and transmembrane proteins: a RT bioinformatics assessment."; RL Genome Res. 13:2265-2270(2003). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [8] RP REVIEW. RX MEDLINE=20047730; PubMed=10580128; DOI=10.1016/S0304-4165(99)00168-3; RA Amado M., Almeida R., Schwientek T., Clausen H.; RT "Identification and characterization of large galactosyltransferase RT gene families: galactosyltransferases for all functions."; RL Biochim. Biophys. Acta 1473:35-53(1999). CC -!- FUNCTION: Has a beta1,3-N-acetylglucosaminyltransferase activity CC for type 2 oligosaccharides. CC -!- PATHWAY: Glycosylation. CC -!- SUBCELLULAR LOCATION: Golgi apparatus; Golgi membrane; single-pass CC type II membrane protein (Potential). CC -!- TISSUE SPECIFICITY: Expressed in colon, jejunum, stomach, CC esophagus, placenta and trachea. CC -!- SIMILARITY: Belongs to the glycosyltransferase 31 family. CC -!- CAUTION: Ref.5 sequence differs from that shown due to several CC frameshifts. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB015630; BAA76497.1; -; mRNA. DR EMBL; AF293973; AAK00849.1; -; mRNA. DR EMBL; AB049585; BAB21531.1; -; mRNA. DR EMBL; AJ130847; CAC45044.1; -; mRNA. DR EMBL; AJ278961; CAC82374.1; ALT_FRAME; mRNA. DR EMBL; AY358955; AAQ89314.1; -; mRNA. DR EMBL; BC066876; AAH66876.1; -; mRNA. DR EMBL; BC067423; AAH67423.1; -; mRNA. DR Ensembl; ENSG00000179913; Homo sapiens. DR HGNC; HGNC:13528; B3GNT3. DR MIM; 605863; gene. DR LinkHub; Q9Y2A9; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR InterPro; IPR002659; Glyco_trans_31. DR PANTHER; PTHR11214; Glyco_trans_31; 1. DR Pfam; PF01762; Galactosyl_T; 1. KW Glycoprotein; Glycosyltransferase; Golgi stack; Membrane; KW Polymorphism; Signal-anchor; Transferase; Transmembrane. FT CHAIN 1 372 UDP-GlcNAc:betaGal beta-1,3-N- FT acetylglucosaminyltransferase 3. FT /FTId=PRO_0000219172. FT TOPO_DOM 1 10 Cytoplasmic (Potential). FT TRANSMEM 11 31 Signal-anchor for type II membrane FT protein (Potential). FT TOPO_DOM 32 372 Lumenal (Potential). FT CARBOHYD 64 64 N-linked (GlcNAc...) (Potential). FT CARBOHYD 184 184 N-linked (GlcNAc...) (Potential). FT CARBOHYD 202 202 N-linked (GlcNAc...) (Potential). FT CARBOHYD 362 362 N-linked (GlcNAc...) (Potential). FT CARBOHYD 367 367 N-linked (GlcNAc...) (Potential). FT VARIANT 328 328 H -> R (in dbSNP:36686). FT /FTId=VAR_022644. FT CONFLICT 89 89 C -> Y (in Ref. 7; AAH66876). FT CONFLICT 355 355 W -> R (in Ref. 7; AAH67423). SQ SEQUENCE 372 AA; 42515 MW; A6E3FE88AFCCFCC2 CRC64; MKYLRHRRPN ATLILAIGAF TLLLFSLLVS PPTCKVQEQP PAIPEALAWP TPPTRPAPAP CHANTSMVTH PDFATQPQHV QNFLLYRHCR HFPLLQDVPP SKCAQPVFLL LVIKSSPSNY VRRELLRRTW GRERKVRGLQ LRLLFLVGTA SNPHEARKVN RLLELEAQTH GDILQWDFHD SFFNLTLKQV LFLQWQETRC ANASFVLNGD DDVFAHTDNM VFYLQDHDPG RHLFVGQLIQ NVGPIRAFWS KYYVPEVVTQ NERYPPYCGG GGFLLSRFTA AALRRAAHVL DIFPIDDVFL GMCLELEGLK PASHSGIRTS GVRAPSQHLS SFDPCFYRDL LLVHRFLPYE MLLMWDALNQ PNLTCGNQTQ IY //