ID   OSGI2_HUMAN             Reviewed;         505 AA.
AC   Q9Y236;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   17-JUN-2020, entry version 141.
DE   RecName: Full=Oxidative stress-induced growth inhibitor 2;
DE   AltName: Full=hT41;
GN   Name=OSGIN2; Synonyms=C8orf1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
RC   TISSUE=Testis;
RX   PubMed=9933573; DOI=10.1006/geno.1998.5657;
RA   Tauchi H., Matsuura S., Isomura M., Kinjo T., Nakamura A., Sakamoto S.,
RA   Kondo N., Endo S., Komatsu K., Nakamura Y.;
RT   "Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21 that
RT   contains the Nijmegen breakage syndrome gene, NBS1.";
RL   Genomics 55:242-247(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in meiosis or the maturation of germ cells.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9Y236-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9Y236-2; Sequence=VSP_041210;
CC   -!- TISSUE SPECIFICITY: Ubiquitous. Expressed at higher levels in testis
CC       and ovary.
CC   -!- SIMILARITY: Belongs to the OKL38 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH31054.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   -!- SEQUENCE CAUTION: [Isoform 2]:
CC       Sequence=AAH31054.2; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AF061326; AAD18134.1; -; mRNA.
DR   EMBL; AF069291; AAC62231.1; -; Genomic_DNA.
DR   EMBL; AF117829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC031054; AAH31054.2; ALT_SEQ; mRNA.
DR   CCDS; CCDS47888.1; -. [Q9Y236-2]
DR   CCDS; CCDS6248.1; -. [Q9Y236-1]
DR   RefSeq; NP_001119583.1; NM_001126111.2. [Q9Y236-2]
DR   RefSeq; NP_004328.1; NM_004337.2. [Q9Y236-1]
DR   RefSeq; XP_011515589.1; XM_011517287.2. [Q9Y236-1]
DR   BioGRID; 107195; 2.
DR   IntAct; Q9Y236; 1.
DR   STRING; 9606.ENSP00000396445; -.
DR   iPTMnet; Q9Y236; -.
DR   PhosphoSitePlus; Q9Y236; -.
DR   BioMuta; OSGIN2; -.
DR   DMDM; 11386718; -.
DR   EPD; Q9Y236; -.
DR   jPOST; Q9Y236; -.
DR   MassIVE; Q9Y236; -.
DR   PaxDb; Q9Y236; -.
DR   PeptideAtlas; Q9Y236; -.
DR   PRIDE; Q9Y236; -.
DR   ProteomicsDB; 85629; -. [Q9Y236-1]
DR   ProteomicsDB; 85630; -. [Q9Y236-2]
DR   Antibodypedia; 25576; 131 antibodies.
DR   DNASU; 734; -.
DR   Ensembl; ENST00000297438; ENSP00000297438; ENSG00000164823. [Q9Y236-1]
DR   Ensembl; ENST00000451899; ENSP00000396445; ENSG00000164823. [Q9Y236-2]
DR   Ensembl; ENST00000647849; ENSP00000497119; ENSG00000164823. [Q9Y236-1]
DR   GeneID; 734; -.
DR   KEGG; hsa:734; -.
DR   UCSC; uc003yeg.4; human. [Q9Y236-1]
DR   CTD; 734; -.
DR   EuPathDB; HostDB:ENSG00000164823.9; -.
DR   GeneCards; OSGIN2; -.
DR   HGNC; HGNC:1355; OSGIN2.
DR   HPA; ENSG00000164823; Low tissue specificity.
DR   MIM; 604598; gene.
DR   neXtProt; NX_Q9Y236; -.
DR   OpenTargets; ENSG00000164823; -.
DR   PharmGKB; PA162398506; -.
DR   eggNOG; ENOG410IF6I; Eukaryota.
DR   eggNOG; ENOG410ZAI8; LUCA.
DR   GeneTree; ENSGT00390000006658; -.
DR   HOGENOM; CLU_019308_2_0_1; -.
DR   InParanoid; Q9Y236; -.
DR   OMA; KCVLQSA; -.
DR   OrthoDB; 890629at2759; -.
DR   PhylomeDB; Q9Y236; -.
DR   TreeFam; TF313502; -.
DR   BioGRID-ORCS; 734; 1 hit in 790 CRISPR screens.
DR   ChiTaRS; OSGIN2; human.
DR   GenomeRNAi; 734; -.
DR   Pharos; Q9Y236; Tbio.
DR   PRO; PR:Q9Y236; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q9Y236; protein.
DR   Bgee; ENSG00000164823; Expressed in sperm and 178 other tissues.
DR   ExpressionAtlas; Q9Y236; baseline and differential.
DR   Genevisible; Q9Y236; HS.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0030308; P:negative regulation of cell growth; IBA:GO_Central.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR029731; OKL38_fam.
DR   InterPro; IPR029728; OSGIN2.
DR   PANTHER; PTHR15192; PTHR15192; 1.
DR   PANTHER; PTHR15192:SF4; PTHR15192:SF4; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Meiosis; Polymorphism; Reference proteome.
FT   CHAIN           1..505
FT                   /note="Oxidative stress-induced growth inhibitor 2"
FT                   /id="PRO_0000165372"
FT   VAR_SEQ         1
FT                   /note="M -> MPVWCCRCSLAGHFRNYSDTETEGEIFNSLVQYFGDNLGRKVKAM
FT                   (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_041210"
FT   VARIANT         101
FT                   /note="Y -> H (in dbSNP:rs35542900)"
FT                   /id="VAR_050421"
FT   VARIANT         319
FT                   /note="C -> S (in dbSNP:rs35599414)"
FT                   /id="VAR_050422"
SQ   SEQUENCE   505 AA;  56672 MW;  7AFDA45D8E8ECA8F CRC64;
     MPLVEETSLL EDSSVTFPVV IIGNGPSGIC LSYMLSGYRP YLSSEAIHPN TILNSKLEEA
     RHLSIVDQDL EYLSEGLEGR SSNPVAVLFD TLLHPDADFG YDYPSVLHWK LEQHHYIPHV
     VLGKGPPGGA WHNMEGSMLT ISFGSWMELP GLKFKDWVSS KRRSLKGDRV MPEEIARYYK
     HYVKVMGLQK NFRENTYITS VSRLYRDQDD DDIQDRDIST KHLQIEKSNF IKRNWEIRGY
     QRIADGSHVP FCLFAENVAL ATGTLDSPAH LEIEGEDFPF VFHSMPEFGA AINKGKLRGK
     VDPVLIVGSG LTAADAVLCA YNSNIPVIHV FRRRVTDPSL IFKQLPKKLY PEYHKVYHMM
     CTQSYSVDSN LLSDYTSFPE HRVLSFKSDM KCVLQSVSGL KKIFKLSAAV VLIGSHPNLS
     FLKDQGCYLG HKSSQPITCK GNPVEIDTYT YECIKEANLF ALGPLVGDNF VRFLKGGALG
     VTRCLATRQK KKHLFVERGG GDGIA
//