ID TJAM_HUMAN STANDARD; PRT; 531 AA. AC Q9Y228; Q7Z706; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE TRAF3-interacting JNK-activating modulator. GN T3JAM. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Rhodes S.; RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE FROM N.A. RA Grafham D.; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: May function as an adapter molecule that regulates CC TRAF3-mediated JNK activation (By similarity). CC -!- SUBUNIT: Binds to the isoleucine zipper of TRAF3 via its coiled- CC coil domain (By similarity). CC -!- SUBCELLULAR LOCATION: Type IV membrane protein (Potential). CC -!- CAUTION: Ref.2 (CAA18543) sequence differs from that shown due to CC erroneous gene model prediction. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL049667; CAB41242.1; -. DR EMBL; AL022398; CAA18543.1; ALT_SEQ. DR EMBL; AL022398; CAA18547.1; -. DR MIM; 608255; -. KW Coiled coil; Transmembrane. FT DOMAIN 1 503 Cytoplasmic (Potential). FT TRANSMEM 504 524 Anchor for type IV membrane protein FT (Potential). FT DOMAIN 525 531 Extracellular (Potential). FT DOMAIN 244 498 Coiled coil (Potential). FT DOMAIN 279 410 Gln-rich. SQ SEQUENCE 531 AA; 61374 MW; 3ABAB20EEB018E30 CRC64; MISPDPRPSP GLARWAESYE AKCERRQEIR ESRRCRPNVT TCRQVGKTLR IQQREQLQRA RLQQFFRRRN LELEEKGKAQ HPQAREQGPS RRPGQVTGTS SEVFPAQHPP PSGICRDLSD HLSSQAGGLP PQDTPIKKPP KHHRGTQTKA EGPTIKNDAS QQTNYGVAVL DKEIIQLSDY LKEALQRELV LKQKMVILQD LLSTLIQASD SSWKGQLNED KLKGKLRSLE NQLYTCTQKY SPWGMKKVLL EMEDQKNSYE QKAKESLQKV LEEKMNAEQQ LQSTQRSLAL AEQKCEEWRS QYEALKEDWR TLGTQHRELE SQLHVLQSKL QGADSRDLQM NQALRFLENE HQQLQAKIEC LQGDRDLCSL DTQDLQDQLK RSEAEKLTLV TRVQQLQGLL QNQSLQLQEQ EKLLTKKDQA LPVWSPKSFP NEVEPEGTGK EKDWDLRDQL QKKTLQLQAK EKECRELHSE LDNLSDEYLS CLRKLQHCRE ELNQSQQLPP RRQCGRWLPV LMVVIAAALA VFLANKDNLM I //