ID T3JAM_HUMAN STANDARD; PRT; 551 AA. AC Q9Y228; Q2YDB5; Q4VY06; Q7Z706; DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot. DT 21-FEB-2006, sequence version 2. DT 30-MAY-2006, entry version 24. DE TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein DE 3). GN Name=TRAF3IP3; Synonyms=T3JAM; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). RA Rhodes S.; RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1). RG Human chromosome 1 international sequencing consortium; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RC TISSUE=Blood; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: May function as an adapter molecule that regulates CC TRAF3-mediated JNK activation (By similarity). CC -!- SUBUNIT: Binds to the isoleucine zipper of TRAF3 via its coiled- CC coil domain (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; single-pass type IV membrane CC protein (Potential). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q9Y228-1; Sequence=Displayed; CC Note=No experimental confirmation available; CC Name=2; CC IsoId=Q9Y228-2; Sequence=VSP_017271; CC Name=3; CC IsoId=Q9Y228-3; Sequence=VSP_017272, VSP_017273; CC Note=No experimental confirmation available; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL049667; CAB41242.1; -; mRNA. DR EMBL; AL022398; CAI95687.1; -; Genomic_DNA. DR EMBL; BC110302; AAI10303.1; -; mRNA. DR UniGene; Hs.147434; -. DR IntAct; Q9Y228; -. DR Ensembl; ENSG00000009790; Homo sapiens. DR HGNC; HGNC:30766; TRAF3IP3. DR MIM; 608255; gene. KW Alternative splicing; Coiled coil; Membrane; Polymorphism; KW Transmembrane. FT CHAIN 1 551 TRAF3-interacting JNK-activating FT modulator. FT /FTId=PRO_0000072403. FT TOPO_DOM 1 526 Cytoplasmic (Potential). FT TRANSMEM 527 544 Anchor for type IV membrane protein FT (Potential). FT TOPO_DOM 545 551 Extracellular (Potential). FT COILED 240 436 Potential. FT COILED 464 506 Potential. FT VAR_SEQ 95 114 Missing (in isoform 2). FT /FTId=VSP_017271. FT VAR_SEQ 352 353 GA -> IN (in isoform 3). FT /FTId=VSP_017272. FT VAR_SEQ 354 551 Missing (in isoform 3). FT /FTId=VSP_017273. FT VARIANT 373 373 Q -> E (in dbSNP:669694). FT /FTId=VAR_024283. SQ SEQUENCE 551 AA; 63626 MW; EA2DFF45A8D6ED19 CRC64; MISPDPRPSP GLARWAESYE AKCERRQEIR ESRRCRPNVT TCRQVGKTLR IQQREQLQRA RLQQFFRRRN LELEEKGKAQ HPQAREQGPS RRPGQVTVLK EPLSCARRIS SPREQVTGTS SEVFPAQHPP PSGICRDLSD HLSSQAGGLP PQDTPIKKPP KHHRGTQTKA EGPTIKNDAS QQTNYGVAVL DKEIIQLSDY LKEALQRELV LKQKMVILQD LLSTLIQASD SSWKGQLNED KLKGKLRSLE NQLYTCTQKY SPWGMKKVLL EMEDQKNSYE QKAKESLQKV LEEKMNAEQQ LQSTQRSLAL AEQKCEEWRS QYEALKEDWR TLGTQHRELE SQLHVLQSKL QGADSRDLQM NQALRFLENE HQQLQAKIEC LQGDRDLCSL DTQDLQDQLK RSEAEKLTLV TRVQQLQGLL QNQSLQLQEQ EKLLTKKDQA LPVWSPKSFP NEVEPEGTGK EKDWDLRDQL QKKTLQLQAK EKECRELHSE LDNLSDEYLS CLRKLQHCRE ELNQSQQLPP RRQCGRWLPV LMVVIAAALA VFLANKDNLM I //