ID T3JAM_HUMAN STANDARD; PRT; 531 AA. AC Q9Y228; Q7Z706; DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1999, sequence version 1. DT 07-FEB-2006, entry version 20. DE TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein DE 3). GN Name=TRAF3IP3; Synonyms=T3JAM; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Rhodes S.; RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Human chromosome 1 international sequencing consortium; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: May function as an adapter molecule that regulates CC TRAF3-mediated JNK activation (By similarity). CC -!- SUBUNIT: Binds to the isoleucine zipper of TRAF3 via its coiled- CC coil domain (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; single-pass type IV membrane CC protein (Potential). CC -!- CAUTION: Ref.2 (CAA18543) sequence differs from that shown due to CC erroneous gene model prediction. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL049667; CAB41242.1; -; mRNA. DR EMBL; AL022398; CAA18543.1; ALT_SEQ; Genomic_DNA. DR EMBL; AL022398; CAA18547.1; -; Genomic_DNA. DR Ensembl; ENSG00000009790; Homo sapiens. DR HGNC; HGNC:30766; TRAF3IP3. DR MIM; 608255; gene. KW Coiled coil; Membrane; Polymorphism; Transmembrane. FT CHAIN 1 531 TRAF3-interacting JNK-activating FT modulator. FT /FTId=PRO_0000072403. FT TOPO_DOM 1 503 Cytoplasmic (Potential). FT TRANSMEM 504 524 Anchor for type IV membrane protein FT (Potential). FT TOPO_DOM 525 531 Extracellular (Potential). FT COILED 244 498 Potential. FT COMPBIAS 279 410 Gln-rich. FT VARIANT 353 353 Q -> E (in dbSNP:669694). FT /FTId=VAR_024283. SQ SEQUENCE 531 AA; 61375 MW; 3ABAB20EEB018E30 CRC64; MISPDPRPSP GLARWAESYE AKCERRQEIR ESRRCRPNVT TCRQVGKTLR IQQREQLQRA RLQQFFRRRN LELEEKGKAQ HPQAREQGPS RRPGQVTGTS SEVFPAQHPP PSGICRDLSD HLSSQAGGLP PQDTPIKKPP KHHRGTQTKA EGPTIKNDAS QQTNYGVAVL DKEIIQLSDY LKEALQRELV LKQKMVILQD LLSTLIQASD SSWKGQLNED KLKGKLRSLE NQLYTCTQKY SPWGMKKVLL EMEDQKNSYE QKAKESLQKV LEEKMNAEQQ LQSTQRSLAL AEQKCEEWRS QYEALKEDWR TLGTQHRELE SQLHVLQSKL QGADSRDLQM NQALRFLENE HQQLQAKIEC LQGDRDLCSL DTQDLQDQLK RSEAEKLTLV TRVQQLQGLL QNQSLQLQEQ EKLLTKKDQA LPVWSPKSFP NEVEPEGTGK EKDWDLRDQL QKKTLQLQAK EKECRELHSE LDNLSDEYLS CLRKLQHCRE ELNQSQQLPP RRQCGRWLPV LMVVIAAALA VFLANKDNLM I //