ID T3JAM_HUMAN Reviewed; 551 AA. AC Q9Y228; A1L464; A6NIU9; Q2YDB5; Q4VY06; Q7Z706; DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot. DT 21-FEB-2006, sequence version 2. DT 29-APR-2015, entry version 104. DE RecName: Full=TRAF3-interacting JNK-activating modulator; DE AltName: Full=TRAF3-interacting protein 3; GN Name=TRAF3IP3; Synonyms=T3JAM; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RA Rhodes S.; RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1). RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., RA Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLU-373. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT RP GLU-373. RC TISSUE=Blood, and Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-267. RC TISSUE=Lung adenocarcinoma; RX PubMed=17203973; DOI=10.1021/pr060438j; RA Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., RA Haines D.S., Figeys D.; RT "The proteomic reactor facilitates the analysis of affinity-purified RT proteins by mass spectrometry: application for identifying RT ubiquitinated proteins in human cells."; RL J. Proteome Res. 6:298-305(2007). RN [6] RP VARIANT [LARGE SCALE ANALYSIS] SER-529. RX PubMed=16959974; DOI=10.1126/science.1133427; RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., RA Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., RA Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., RA Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., RA Vogelstein B., Kinzler K.W., Velculescu V.E.; RT "The consensus coding sequences of human breast and colorectal RT cancers."; RL Science 314:268-274(2006). CC -!- FUNCTION: May function as an adapter molecule that regulates CC TRAF3-mediated JNK activation. {ECO:0000250}. CC -!- SUBUNIT: Binds to the isoleucine zipper of TRAF3 via its coiled- CC coil domain. {ECO:0000250}. CC -!- INTERACTION: CC Q8N6L0:CCDC155; NbExp=3; IntAct=EBI-765817, EBI-749265; CC Q96GN5:CDCA7L; NbExp=3; IntAct=EBI-765817, EBI-5278764; CC P50402:EMD; NbExp=3; IntAct=EBI-765817, EBI-489887; CC Q969F0:FATE1; NbExp=3; IntAct=EBI-765817, EBI-743099; CC Q9Y3A3:MOB4; NbExp=2; IntAct=EBI-765817, EBI-713935; CC Q9GZM8:NDEL1; NbExp=3; IntAct=EBI-765817, EBI-928842; CC O43586:PSTPIP1; NbExp=3; IntAct=EBI-765817, EBI-1050964; CC Q9BRV8:SIKE1; NbExp=2; IntAct=EBI-765817, EBI-1773646; CC P23497:SP100; NbExp=3; IntAct=EBI-765817, EBI-751145; CC O60232:SSSCA1; NbExp=3; IntAct=EBI-765817, EBI-741415; CC Q9Y6E0:STK24; NbExp=2; IntAct=EBI-765817, EBI-740175; CC Q5VSL9:STRIP1; NbExp=2; IntAct=EBI-765817, EBI-1773588; CC O43815:STRN; NbExp=2; IntAct=EBI-765817, EBI-1046642; CC Q13033:STRN3; NbExp=2; IntAct=EBI-765817, EBI-1053857; CC Q9UBB9:TFIP11; NbExp=3; IntAct=EBI-765817, EBI-1105213; CC Q9NQ86:TRIM36; NbExp=3; IntAct=EBI-765817, EBI-2341518; CC Q9BTA9:WAC; NbExp=3; IntAct=EBI-765817, EBI-749118; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV CC membrane protein {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q9Y228-1; Sequence=Displayed; CC Note=No experimental confirmation available.; CC Name=2; CC IsoId=Q9Y228-2; Sequence=VSP_017271; CC Name=3; CC IsoId=Q9Y228-3; Sequence=VSP_017272, VSP_017273; CC Note=No experimental confirmation available.; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL049667; CAB41242.1; -; mRNA. DR EMBL; AL022398; CAI95687.1; -; Genomic_DNA. DR EMBL; CH471100; EAW93444.1; -; Genomic_DNA. DR EMBL; BC110302; AAI10303.1; -; mRNA. DR EMBL; BC130417; AAI30418.1; -; mRNA. DR EMBL; BC144139; AAI44140.1; -; mRNA. DR CCDS; CCDS1490.2; -. [Q9Y228-1] DR RefSeq; NP_001274683.1; NM_001287754.1. DR RefSeq; NP_079504.2; NM_025228.3. [Q9Y228-1] DR UniGene; Hs.147434; -. DR ProteinModelPortal; Q9Y228; -. DR SMR; Q9Y228; 466-515. DR BioGrid; 123249; 31. DR IntAct; Q9Y228; 41. DR MINT; MINT-6768551; -. DR STRING; 9606.ENSP00000010338; -. DR PhosphoSite; Q9Y228; -. DR BioMuta; TRAF3IP3; -. DR DMDM; 88984949; -. DR MaxQB; Q9Y228; -. DR PaxDb; Q9Y228; -. DR PRIDE; Q9Y228; -. DR DNASU; 80342; -. DR Ensembl; ENST00000367024; ENSP00000355991; ENSG00000009790. [Q9Y228-1] DR Ensembl; ENST00000367025; ENSP00000355992; ENSG00000009790. [Q9Y228-1] DR Ensembl; ENST00000367026; ENSP00000355993; ENSG00000009790. [Q9Y228-2] DR Ensembl; ENST00000478359; ENSP00000417665; ENSG00000009790. [Q9Y228-3] DR GeneID; 80342; -. DR KEGG; hsa:80342; -. DR UCSC; uc001hhm.2; human. [Q9Y228-3] DR UCSC; uc001hhn.3; human. [Q9Y228-2] DR UCSC; uc001hho.3; human. [Q9Y228-1] DR CTD; 80342; -. DR GeneCards; GC01P209929; -. DR H-InvDB; HIX0159943; -. DR HGNC; HGNC:30766; TRAF3IP3. DR HPA; HPA040796; -. DR MIM; 608255; gene. DR neXtProt; NX_Q9Y228; -. DR PharmGKB; PA142670711; -. DR eggNOG; NOG81914; -. DR GeneTree; ENSGT00530000063197; -. DR HOGENOM; HOG000070108; -. DR HOVERGEN; HBG054704; -. DR InParanoid; Q9Y228; -. DR OMA; KCERRQE; -. DR OrthoDB; EOG7V1FQD; -. DR PhylomeDB; Q9Y228; -. DR TreeFam; TF334641; -. DR ChiTaRS; TRAF3IP3; human. DR GeneWiki; TRAF3IP3; -. DR GenomeRNAi; 80342; -. DR NextBio; 70918; -. DR PRO; PR:Q9Y228; -. DR Proteomes; UP000005640; Chromosome 1. DR Bgee; Q9Y228; -. DR CleanEx; HS_TRAF3IP3; -. DR ExpressionAtlas; Q9Y228; baseline and differential. DR Genevestigator; Q9Y228; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. PE 1: Evidence at protein level; KW Alternative splicing; Coiled coil; Complete proteome; Isopeptide bond; KW Membrane; Polymorphism; Reference proteome; Transmembrane; KW Transmembrane helix; Ubl conjugation. FT CHAIN 1 551 TRAF3-interacting JNK-activating FT modulator. FT /FTId=PRO_0000072403. FT TOPO_DOM 1 526 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 527 544 Helical; Anchor for type IV membrane FT protein. {ECO:0000255}. FT TOPO_DOM 545 551 Extracellular. {ECO:0000255}. FT COILED 240 436 {ECO:0000255}. FT COILED 464 506 {ECO:0000255}. FT CROSSLNK 267 267 Glycyl lysine isopeptide (Lys-Gly) FT (interchain with G-Cter in ubiquitin). FT {ECO:0000269|PubMed:17203973}. FT VAR_SEQ 95 114 Missing (in isoform 2). FT {ECO:0000303|Ref.1}. FT /FTId=VSP_017271. FT VAR_SEQ 352 353 GA -> IN (in isoform 3). FT {ECO:0000303|PubMed:15489334}. FT /FTId=VSP_017272. FT VAR_SEQ 354 551 Missing (in isoform 3). FT {ECO:0000303|PubMed:15489334}. FT /FTId=VSP_017273. FT VARIANT 373 373 Q -> E (in dbSNP:rs669694). FT {ECO:0000269|PubMed:15489334, FT ECO:0000269|Ref.3}. FT /FTId=VAR_024283. FT VARIANT 529 529 P -> S (in a colorectal cancer sample; FT somatic mutation). FT {ECO:0000269|PubMed:16959974}. FT /FTId=VAR_035664. SQ SEQUENCE 551 AA; 63626 MW; EA2DFF45A8D6ED19 CRC64; MISPDPRPSP GLARWAESYE AKCERRQEIR ESRRCRPNVT TCRQVGKTLR IQQREQLQRA RLQQFFRRRN LELEEKGKAQ HPQAREQGPS RRPGQVTVLK EPLSCARRIS SPREQVTGTS SEVFPAQHPP PSGICRDLSD HLSSQAGGLP PQDTPIKKPP KHHRGTQTKA EGPTIKNDAS QQTNYGVAVL DKEIIQLSDY LKEALQRELV LKQKMVILQD LLSTLIQASD SSWKGQLNED KLKGKLRSLE NQLYTCTQKY SPWGMKKVLL EMEDQKNSYE QKAKESLQKV LEEKMNAEQQ LQSTQRSLAL AEQKCEEWRS QYEALKEDWR TLGTQHRELE SQLHVLQSKL QGADSRDLQM NQALRFLENE HQQLQAKIEC LQGDRDLCSL DTQDLQDQLK RSEAEKLTLV TRVQQLQGLL QNQSLQLQEQ EKLLTKKDQA LPVWSPKSFP NEVEPEGTGK EKDWDLRDQL QKKTLQLQAK EKECRELHSE LDNLSDEYLS CLRKLQHCRE ELNQSQQLPP RRQCGRWLPV LMVVIAAALA VFLANKDNLM I //